Cabazitaxel
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- $29 - $3980
- Product name: Cabazitaxel
- CAS: 183133-96-2
- MF: C45H57NO14
- MW: 835.93
- EINECS:680-632-7
- MDL Number:MFCD18827611
- Synonyms:(2AR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-;TXD-258;(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;XRP 6258;Cabazitaxel;β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl;7β, 10β-DiMethoxydocetaxel;Cabazitaxel(XRP-6258)
54 prices
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Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- BroadPharm
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Frontier Specialty Chemicals
- JR MediChem
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 1mg
- 5MG
- 10mg
- 20mg
- 25mg
- 50MG
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 2g
- 10g
- 20g
- ManufacturerAK Scientific
- Product numberX7252
- Product descriptionCabazitaxel
- Packaging1mg
- Price$29
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7252
- Product descriptionCabazitaxel
- Packaging500mg
- Price$879
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005344
- Product descriptionCABAZITAXEL 95.00%
- Packaging50MG
- Price$2425.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005344
- Product descriptionCABAZITAXEL 95.00%
- Packaging5MG
- Price$847
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2157
- Product descriptionCabazitaxel
- Packaging25mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60306
- Product descriptionCabazitaxel
- Packaging20mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS021351
- Product description(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98%
- Packaging100mg
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS021351
- Product description(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98%
- Packaging250mg
- Price$236
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS021351
- Product description(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98%
- Packaging1g
- Price$586
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2677
- Product descriptionCabazitaxel
- Packaging5mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2677
- Product descriptionCabazitaxel
- Packaging10mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2677
- Product descriptionCabazitaxel
- Packaging100mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2677
- Product descriptionCabazitaxel
- Packaging1g
- Price$329
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2677
- Product descriptionCabazitaxel
- Packaging10g
- Price$2290
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb594549
- Product descriptionCabazitaxel
- Packaging20mg
- Price$372.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb594549
- Product descriptionCabazitaxel
- Packaging100mg
- Price$571.2
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7252 | Cabazitaxel | 1mg | $29 | 2021-12-16 | Buy |
| AK Scientific | X7252 | Cabazitaxel | 500mg | $879 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005344 | CABAZITAXEL 95.00% | 50MG | $2425.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005344 | CABAZITAXEL 95.00% | 5MG | $847 | 2021-12-16 | Buy |
| ApexBio Technology | B2157 | Cabazitaxel | 25mg | $200 | 2021-12-16 | Buy |
| Arctom | CFN60306 | Cabazitaxel | 20mg | $118 | 2021-12-16 | Buy |
| Arctom | AS021351 | (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98% | 100mg | $156 | 2021-12-16 | Buy |
| Arctom | AS021351 | (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98% | 250mg | $236 | 2021-12-16 | Buy |
| Arctom | AS021351 | (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98% | 1g | $586 | 2021-12-16 | Buy |
| AvaChem | 2677 | Cabazitaxel | 5mg | $39 | 2021-12-16 | Buy |
| AvaChem | 2677 | Cabazitaxel | 10mg | $59 | 2021-12-16 | Buy |
| AvaChem | 2677 | Cabazitaxel | 100mg | $119 | 2021-12-16 | Buy |
| AvaChem | 2677 | Cabazitaxel | 1g | $329 | 2021-12-16 | Buy |
| AvaChem | 2677 | Cabazitaxel | 10g | $2290 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb594549 | Cabazitaxel | 20mg | $372.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb594549 | Cabazitaxel | 100mg | $571.2 | 2021-12-16 | Buy |
Properties
Melting point :180 °C
Boiling point :870.7±65.0 °C(Predicted)
Density :1.31
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :White solid.
pka :11.20±0.46(Predicted)
color :White to Off-White
InChIKey :BMQGVNUXMIRLCK-JACFBOAKNA-N
Boiling point :870.7±65.0 °C(Predicted)
Density :1.31
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :White solid.
pka :11.20±0.46(Predicted)
color :White to Off-White
InChIKey :BMQGVNUXMIRLCK-JACFBOAKNA-N
Safety Information
| Symbol(GHS): |
 
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Description
In June 2010, the U.S. FDA approved cabazitaxel (also referred to as XRP6258 and RPR 116258A) in combination with the steroid prednisone for the treatment of metastatic Castration-Resistant Prostate Cancer (mCRPC) for patients who were previously treated with a docetaxelcontaining regimen for late-stage disease.Cabazitaxel is a semisynthetic analog of the natural product taxol, which is isolated from the bark of the yew tree. Cabazitaxel is a microtubule inhibitor that binds to the taxol-binding site of tubulin. Similar to other tubulin inhibitors of the taxol class, cabazitaxel inhibits microtubule disassembly resulting in mitotic blockade and cell death. Docetaxel, also a semisynthetic taxol analog, was approved by the FDA for the treatment of mCRPC in 2004. However, docetaxel is a substrate for P-gp, which is thought to contribute to the constitutive and acquired resistance of cancer cells to taxanes. Cabazitaxel has poor affinity for P-gp and showed antitumor activity in preclinical in vitro studies and in vivo tumor models that overexpress this protein. Cabazitaxel is synthesized on a commercial scale from 10-deacetylbaccatin .
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Suppliers and manufacturers
SICHUAN XIELI PHARMACEUTICAL CO.,LTD.
Protheragen-ING
Capot Chemical Co.,Ltd.
