Cabazitaxel NEW
Price | Get Latest Price |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 10000kg |
Update Time: | 2024-05-01 |
Product Details
Product Name: Cabazitaxel | CAS No.: 183133-96-2 |
EC-No.: 680-632-7 | Min. Order: 1kg |
Purity: 99% | Supply Ability: 10000kg |
Release date: 2024/05/01 |
Factory Provide Anti-Cancer Raw Powder CAS 183133-96-2 Cabazitaxel
Introduction
Product Name : Cabazitaxel
Othe name :;Cabazitaxel;XRP6258;RPR-116258A;TAXOID XRP6258;TXD 258;
CAS No. 183133-96-2
Molecular Formula: C45H57NO14
MW: 835.93
Assay: 99%
Appearance: White powder
Melting Point :180 °C
Boiling Point :870.7±65.0 °C(Predicted)
Density :1.31
Storage :Sealed in dry,Room Temperature
Cabazitaxel (previously XRP-6258) is a semi-synthetic derivative of a natural taxoid. It was developed by Sanofi-Aventis and was approved by the U.S. FDA for the treatment of hormone-refractory prostate cancer on June 17, 2010. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy.
Cabazitaxel in combination is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment.
Cabazitaxel anticancer mechanism and characteristics similar with docetaxel, belongs to anti-microtubule drugs. Cabazitaxel through binding to tubulin, promoting their assembly into microtubules, and can prevent these have assembled a microtubule disintegration of the stabilization of microtubules, thereby inhibiting cell mitosis, and interphase cellular functions (interphasecellularfunctions) of play.
Specification
ITEM | SPECIFICATION | RESULT | METHOD |
Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
Specific Optical | -2.4°~ -2.8° | -2.72° | |
Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
pH | 4.5~7.0 | 5.10 | |
Related substance | Spot not bigger than standard solution spot | No spot | TLC |
Water Content | ≤2% | 0.26% | KF |
Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Application
1. Cabazitaxel's mechanism and characteristics are similar to docetaxel and belong to anti-microtubule.
2. Cabazitaxel promotes its assembly into microtubules by binding to tubulin, while preventing the disassembly of these assembled microtubules, stabilizing microtubules, thereby inhibiting cell mitosis, and interphase cellular functions.
Company Profile Introduction
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$50.00/1mL |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
$0.00/1g |
VIP1Y
|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
|
2024-09-05 | |
$10.70/1kg |
VIP4Y
|
Hebei Chuanghai Biotechnology Co,.LTD
|
2024-08-20 | |
$0.00/25kg |
Shaanxi Haibo Biotechnology Co., Ltd
|
2023-09-07 | ||
$50.00/1kg |
Henan Bao Enluo International TradeCo.,LTD
|
2023-08-16 | ||
$0.00/1kg |
VIP2Y
|
Hangzhou ICH Biofarm Co., Ltd
|
2023-06-26 | |
$0.00/1Kg |
VIP3Y
|
Changzhou Rokechem Technology Co., Ltd.
|
2023-06-21 | |
$0.00/1g |
VIP4Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2021-07-27 | |
$15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
$1.10/1g |
VIP4Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2021-05-26 |