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ChemicalBook >> CAS DataBase List >> Bindarit

Bindarit

Bindarit price.
  • $25 - $1800
  • Product name: Bindarit
  • CAS: 130641-38-2
  • MF: C19H20N2O3
  • MW: 324.37
  • EINECS:
  • MDL Number:MFCD00866723
  • Synonyms:Bindarit;Propanoic acid, 2-Methyl-2-[[1-(phenylMethyl)-1H-indazol-3-yl]Methoxy]-;2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid;AF 2838;2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid;AF2838;AF-2838;AF 2838;CS-1989;2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid
19 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Usbiological
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX6136
  • Product descriptionBindarit
  • Packaging100mg
  • Price$455
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0010496
  • Product description2-(1-BENZYL-1H-INDAZOL-3-YL)METHOXY-2-METHYLPROPANOIC ACID 95.00%
  • Packaging5MG
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBB161276
  • Product descriptionBindarit
  • Packaging25mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBB161276
  • Product descriptionBindarit
  • Packaging50mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBB161276
  • Product descriptionBindarit
  • Packaging100mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBB161276
  • Product descriptionBindarit
  • Packaging250mg
  • Price$600
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBB161276
  • Product descriptionBindarit
  • Packaging500mg
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11479
  • Product descriptionBindarit ≥98%
  • Packaging1mg
  • Price$25
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11479
  • Product descriptionBindarit ≥98%
  • Packaging5mg
  • Price$88
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11479
  • Product descriptionBindarit ≥98%
  • Packaging10mg
  • Price$150
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11479
  • Product descriptionBindarit ≥98%
  • Packaging25mg
  • Price$250
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2620
  • Product descriptionBindarit 99.68%
  • Packaging10mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2620
  • Product descriptionBindarit 99.68%
  • Packaging50mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2620
  • Product descriptionBindarit 99.68%
  • Packaging100mg
  • Price$1200
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003946
  • Product descriptionBindarit 95+%
  • Packaging50mg
  • Price$572
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003946
  • Product descriptionBindarit 95+%
  • Packaging100mg
  • Price$952
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X6136 Bindarit 100mg $455 2021-12-16 Buy
American Custom Chemicals Corporation API0010496 2-(1-BENZYL-1H-INDAZOL-3-YL)METHOXY-2-METHYLPROPANOIC ACID 95.00% 5MG $330 2021-12-16 Buy
Biosynth Carbosynth BB161276 Bindarit 25mg $100 2021-12-16 Buy
Biosynth Carbosynth BB161276 Bindarit 50mg $175 2021-12-16 Buy
Biosynth Carbosynth BB161276 Bindarit 100mg $300 2021-12-16 Buy
Biosynth Carbosynth BB161276 Bindarit 250mg $600 2021-12-16 Buy
Biosynth Carbosynth BB161276 Bindarit 500mg $900 2021-12-16 Buy
Cayman Chemical 11479 Bindarit ≥98% 1mg $25 2024-03-01 Buy
Cayman Chemical 11479 Bindarit ≥98% 5mg $88 2024-03-01 Buy
Cayman Chemical 11479 Bindarit ≥98% 10mg $150 2024-03-01 Buy
Cayman Chemical 11479 Bindarit ≥98% 25mg $250 2024-03-01 Buy
ChemScene CS-2620 Bindarit 99.68% 10mg $240 2021-12-16 Buy
ChemScene CS-2620 Bindarit 99.68% 50mg $720 2021-12-16 Buy
ChemScene CS-2620 Bindarit 99.68% 100mg $1200 2021-12-16 Buy
Crysdot CD31003946 Bindarit 95+% 50mg $572 2021-12-16 Buy
Crysdot CD31003946 Bindarit 95+% 100mg $952 2021-12-16 Buy

Properties

Boiling point :542.9±40.0 °C(Predicted)
Density :1.18±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. :2-8°C
solubility :DMSO:47.0(Max Conc. mg/mL);144.89(Max Conc. mM)
form :A crystalline solid
pka :3.59±0.10(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Monocyte chemoattractant protein-1 (MCP-1/CCL2) and other members of the MCP cluster (MCP-2/CCL8 and MCP-3/CCL7) are potent chemotactic cytokines that collaboratively promote inflammation through monocyte-macrophage recruitment. Bindarit is an indazolic derivative that inhibits the expression of CCL2, CCL7, and CCL8, as well as IL-12. It can inhibit LPS- or C. albicans-induced production of CCL2 in human monocytes with IC50 values of 172 and 403 μM, respectively. Bindarit has been shown to downregulate the NF-κB pathway, preventing p65 and p65/p50-mediated CCL2 promoter activation. Through potent suppression of CCL2 transcription, bindarit has been reported to reduce symptoms in several animal models of human inflammatory diseases, including lupus nephritis, arthritis, cancer, and encephalomyelitis.

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