BLU9931
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- $24 - $1850
- Product name: BLU9931
- CAS: 1538604-68-0
- MF: C26H22Cl2N4O3
- MW: 509.38
- EINECS:-0
- MDL Number:MFCD28900729
- Synonyms:BLU 9931;BLU9931;BLU-9931;LM-3610;LM-3610; BLU9931;N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide;N-[2-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]-3-methylphenyl]-2-propenamide;2-Propenamide,N-[2-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]-3-methylphenyl]-
24 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number4064DW
- Product descriptionN-[2-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]-3-methylphenyl]prop-2-enamide
- Packaging10mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA231990
- Product descriptionN-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+%
- Packaging1mg
- Price$24
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA231990
- Product descriptionN-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+%
- Packaging5mg
- Price$47
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA231990
- Product descriptionN-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+%
- Packaging10mg
- Price$76
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA231990
- Product descriptionN-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+%
- Packaging25mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA231990
- Product descriptionN-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+%
- Packaging50mg
- Price$287
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA231990
- Product descriptionN-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+%
- Packaging100mg
- Price$373
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA231990
- Product descriptionN-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+%
- Packaging250mg
- Price$559
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005716
- Product descriptionBLU9931 95.00%
- Packaging5MG
- Price$499.1
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8706
- Product descriptionBLU9931
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18405
- Product descriptionBLU9931 ≥98%
- Packaging1mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18405
- Product descriptionBLU9931 ≥98%
- Packaging5mg
- Price$216
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18405
- Product descriptionBLU9931 ≥98%
- Packaging10mg
- Price$380
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18405
- Product descriptionBLU9931 ≥98%
- Packaging25mg
- Price$711
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-4139
- Product descriptionBLU9931 99.95%
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4139
- Product descriptionBLU9931 99.95%
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4064DW | N-[2-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]-3-methylphenyl]prop-2-enamide | 10mg | $185 | 2021-12-16 | Buy |
| Ambeed | A231990 | N-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+% | 1mg | $24 | 2021-12-16 | Buy |
| Ambeed | A231990 | N-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+% | 5mg | $47 | 2021-12-16 | Buy |
| Ambeed | A231990 | N-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+% | 10mg | $76 | 2021-12-16 | Buy |
| Ambeed | A231990 | N-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+% | 25mg | $144 | 2021-12-16 | Buy |
| Ambeed | A231990 | N-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+% | 50mg | $287 | 2021-12-16 | Buy |
| Ambeed | A231990 | N-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+% | 100mg | $373 | 2021-12-16 | Buy |
| Ambeed | A231990 | N-(2-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide 99+% | 250mg | $559 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005716 | BLU9931 95.00% | 5MG | $499.1 | 2021-12-16 | Buy |
| ApexBio Technology | A8706 | BLU9931 | 5mg | $110 | 2021-12-16 | Buy |
| Cayman Chemical | 18405 | BLU9931 ≥98% | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 18405 | BLU9931 ≥98% | 5mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 18405 | BLU9931 ≥98% | 10mg | $380 | 2024-03-01 | Buy |
| Cayman Chemical | 18405 | BLU9931 ≥98% | 25mg | $711 | 2024-03-01 | Buy |
| ChemScene | CS-4139 | BLU9931 99.95% | 5mg | $55 | 2021-12-16 | Buy |
| ChemScene | CS-4139 | BLU9931 99.95% | 10mg | $90 | 2021-12-16 | Buy |
Properties
Density :1.361±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥50.9 mg/mL in DMSO; insoluble in H2O; ≥2.53 mg/mL in EtOH with gentle warming and ultrasonic
form :Powder
pka :13.15±0.70(Predicted)
color :Off-white to light yellow
storage temp. :Store at -20°C
solubility :≥50.9 mg/mL in DMSO; insoluble in H2O; ≥2.53 mg/mL in EtOH with gentle warming and ultrasonic
form :Powder
pka :13.15±0.70(Predicted)
color :Off-white to light yellow
Safety Information
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Description
Fibroblast growth factor receptor 4 (FGFR4) is the receptor for fibroblast growth factor 19 (FGF19), which is a tightly controlled hormone that regulates bile acid synthesis and hepatocyte proliferation in the normal liver. Aberrant signaling through the FGFR4/FGF19 signaling complex has been implicated in hepatocellular carcinoma (HCC). BLU9931 is a small molecule inhibitor of FGFR4 (IC50 = 3 nM) that is selective for FGFR4 over other FGFR family members (IC50s = 591, 493, and 150 nM for FGFR1, 2, and 3, respectively) and an extensive panel of additional kinases (selectivity score for BLU9931 at 3 μM is 0.005). It inhibits proliferation of HCC cell lines with an activated FGFR4 signaling pathway (EC50s = 0.02-0.11 μM) and demonstrates antitumor activity when administered orally at 100 mg/kg to mice bearing HCC xenografts that overexpresses FGF19 due to amplification or to mice bearing liver tumor xenografts that overexpresses FGF19 mRNA but lack FGF19 amplification.More related product prices
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