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ChemicalBook >> CAS DataBase List >> AZD6738

AZD6738

AZD6738 price.
  • $45 - $2200
  • Product name: AZD6738
  • CAS: 1352226-88-0
  • MF: C20H24N6O2S
  • MW: 412.51
  • EINECS:805-672-6
  • MDL Number:MFCD28952790
  • Synonyms:AZD6738;4-[4-[1-[[S(R)]-S-Methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine;AZD6738(AZD-6738);(R)-imino(methyl)(1-(6-((R)-3-methylmorpholino)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)cyclopropyl)-l6-sulfanone;EOS-61602;(R)-3-methyl-4-(6-(1-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine;1H-Pyrrolo[2,3-b]pyridine, 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-;AZD-6738;AZD 6738;AZD6738
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  • ApexBio Technology
  • Apolloscientific
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 2mg
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  • 10mg
  • 25mg
  • 50mg
  • 2x25mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerApexBio Technology
  • Product numberB6007
  • Product descriptionAZD6738
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6007
  • Product descriptionAZD6738
  • Packaging25mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0127
  • Product descriptionAZD6738
  • Packaging2mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0127
  • Product descriptionAZD6738
  • Packaging5mg
  • Price$254
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0127
  • Product descriptionAZD6738
  • Packaging10mg
  • Price$319
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon3134
  • Product descriptionAZD6738-Ceralasertib 99%
  • Packaging2x25mg
  • Price$572
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA145496
  • Product descriptionAZD 6738
  • Packaging10mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA145496
  • Product descriptionAZD 6738
  • Packaging50mg
  • Price$475
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21035
  • Product descriptionAZD 6738 ≥98%
  • Packaging1mg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21035
  • Product descriptionAZD 6738 ≥98%
  • Packaging5mg
  • Price$216
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21035
  • Product descriptionAZD 6738 ≥98%
  • Packaging10mg
  • Price$380
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21035
  • Product descriptionAZD 6738 ≥98%
  • Packaging25mg
  • Price$830
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM149750
  • Product description(3R)-3-Methyl-4-(6-((2R)-2-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine 95%+
  • Packaging100mg
  • Price$785
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5187
  • Product descriptionCeralasertib 99.76%
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5187
  • Product descriptionCeralasertib 99.76%
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5187
  • Product descriptionCeralasertib 99.76%
  • Packaging50mg
  • Price$528
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology B6007 AZD6738 5mg $120 2021-12-16 Buy
ApexBio Technology B6007 AZD6738 25mg $400 2021-12-16 Buy
Apolloscientific BISN0127 AZD6738 2mg $160 2021-12-16 Buy
Apolloscientific BISN0127 AZD6738 5mg $254 2021-12-16 Buy
Apolloscientific BISN0127 AZD6738 10mg $319 2021-12-16 Buy
Axon Medchem Axon3134 AZD6738-Ceralasertib 99% 2x25mg $572 2021-12-16 Buy
Biosynth Carbosynth FA145496 AZD 6738 10mg $170 2021-12-16 Buy
Biosynth Carbosynth FA145496 AZD 6738 50mg $475 2021-12-16 Buy
Cayman Chemical 21035 AZD 6738 ≥98% 1mg $49 2024-03-01 Buy
Cayman Chemical 21035 AZD 6738 ≥98% 5mg $216 2024-03-01 Buy
Cayman Chemical 21035 AZD 6738 ≥98% 10mg $380 2024-03-01 Buy
Cayman Chemical 21035 AZD 6738 ≥98% 25mg $830 2024-03-01 Buy
Chemenu CM149750 (3R)-3-Methyl-4-(6-((2R)-2-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine 95%+ 100mg $785 2021-12-16 Buy
ChemScene CS-5187 Ceralasertib 99.76% 5mg $120 2021-12-16 Buy
ChemScene CS-5187 Ceralasertib 99.76% 10mg $180 2021-12-16 Buy
ChemScene CS-5187 Ceralasertib 99.76% 50mg $528 2021-12-16 Buy

Properties

Density :1.52±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :12.53±0.40(Predicted)
color :Pale Yellow
InChIKey :OHUHVTCQTUDPIJ-YEMGFFRQNA-N
SMILES :C12NC=CC1=C(C1=NC(N3CCOC[C@H]3C)=CC(C3([S@](C)(=N)=O)CC3)=N1)C=CN=2 |&1:14,19,r|

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

AZD 6738 is an orally bioavailable inhibitor of the serine/threonine protein kinase ataxia telangiectasia mutated (ATM) and Rad3-related (ATR; IC50 = 1 nM). It can inhibit ATR substrate Chk1 Ser345 phosphorylation in cells with an IC50 value of 74 nM. AZD 6738 has been shown to inhibit the proliferation of various solid and hematological cell lines with IC50 values of less than 1 μM and to reduce tumor growth in several ATM-deficient xenograft models. When used in combination with either DNA damaging chemotherapy agents or ionizing radiation, AZD 6738 demonstrated synergistic cell killing activity across multiple cell lines in vitro and in xenograft studies.

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