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ChemicalBook >> CAS DataBase List >> AZD 3759

AZD 3759

AZD 3759 price.
  • $5 - $1375
  • Product name: AZD 3759
  • CAS: 1626387-80-1
  • MF: C22H23ClFN5O3
  • MW: 459.9
  • EINECS:1592732-453-0
  • MDL Number:MFCD29058564
  • Synonyms:AZD 3759;AZD3759;AZD-3759;(2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester;HY-18750;azd3579;1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-;1-PIPERAZINECARBOXYLIC ACID, 2,4-DIMETHYL-, 4-[(3-CHLORO-2-FLUOROPHENYL)AMINO]-7-METHOXY-6-QUINAZOLINYL ESTER
36 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product number9479AL
  • Product descriptionAZD3759
  • Packaging5g
  • Price$1148
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171107
  • Product description(R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+%
  • Packaging1mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171107
  • Product description(R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+%
  • Packaging5mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171107
  • Product description(R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+%
  • Packaging10mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171107
  • Product description(R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+%
  • Packaging50mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171107
  • Product description(R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+%
  • Packaging100mg
  • Price$19
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171107
  • Product description(R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+%
  • Packaging250mg
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171107
  • Product description(R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+%
  • Packaging1g
  • Price$89
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0026520
  • Product descriptionAZD-3759 95.00%
  • Packaging5MG
  • Price$505.75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5962
  • Product descriptionAZD3759
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5962
  • Product descriptionAZD3759
  • Packaging10mM(in 1mL DMSO)
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5962
  • Product descriptionAZD3759
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5962
  • Product descriptionAZD3759
  • Packaging50mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5962
  • Product descriptionAZD3759
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3369
  • Product descriptionAZD3759
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3369
  • Product descriptionAZD3759
  • Packaging25mg
  • Price$195
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9479AL AZD3759 5g $1148 2021-12-16 Buy
Ambeed A171107 (R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+% 1mg $5 2021-12-16 Buy
Ambeed A171107 (R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+% 5mg $7 2021-12-16 Buy
Ambeed A171107 (R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+% 10mg $9 2021-12-16 Buy
Ambeed A171107 (R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+% 50mg $15 2021-12-16 Buy
Ambeed A171107 (R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+% 100mg $19 2021-12-16 Buy
Ambeed A171107 (R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+% 250mg $36 2021-12-16 Buy
Ambeed A171107 (R)-4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl2,4-dimethylpiperazine-1-carboxylate 98+% 1g $89 2021-12-16 Buy
American Custom Chemicals Corporation API0026520 AZD-3759 95.00% 5MG $505.75 2021-12-16 Buy
ApexBio Technology B5962 AZD3759 5mg $70 2021-12-16 Buy
ApexBio Technology B5962 AZD3759 10mM(in 1mL DMSO) $88 2021-12-16 Buy
ApexBio Technology B5962 AZD3759 10mg $100 2021-12-16 Buy
ApexBio Technology B5962 AZD3759 50mg $300 2021-12-16 Buy
ApexBio Technology B5962 AZD3759 100mg $450 2021-12-16 Buy
AvaChem 3369 AZD3759 5mg $75 2021-12-16 Buy
AvaChem 3369 AZD3759 25mg $195 2021-12-16 Buy

Properties

Boiling point :571.4±50.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23 mg/mL in DMSO; insoluble in H2O; ≥8.32 mg/mL in EtOH with ultrasonic
form :solid
pka :6.71±0.40(Predicted)
color :White to off-white
InChIKey :MXDSJQHFFDGFDK-CYBMUJFWSA-N
SMILES :N1(C(OC2C(OC)=CC3C(C=2)=C(NC2=CC=CC(Cl)=C2F)N=CN=3)=O)CCN(C)C[C@H]1C

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

AZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system. 

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