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ChemicalBook >> CAS DataBase List >> ACTINONIN

ACTINONIN

ACTINONIN price.
  • $76 - $2000
  • Product name: ACTINONIN
  • CAS: 13434-13-4
  • MF: C19H35N3O5
  • MW: 385.5
  • EINECS:
  • MDL Number:MFCD00058569
  • Synonyms:(-)-ACTINONIN;3-[[1-[[2-(HYDROXYMETHYL)-1-PYRROLIDINYL]CARBONYL]-2-METHYL-PROPYL]CARBAMOYL]OCTANOHYDROXAMIC ACID;3-[[1-[[2-(HYDROXYMETHYL)-1-PYRROLIDINYL]-CARBONYL]-2-METHYLPROPYL]-CARBAMOYL]-OCTONOHYDROXAMIC ACID;N4-HYDROXY-N1-[(1S)-1[[(2S)-2-(HYDROXYMETHYL)-1-PYRROLDINYL]CARBONYL]-2-METHYLPROPYL]-2-PENTYL-,(2R)-(9CI);hylpropyl)carbamoyl)- ;octanohydroxamicacid,3-((1-((2-(hydroxymethyl)-1-pyrrolidinyl)carbonyl)-2-met ;N'-Hydroxy-N-[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentylbutanediamide;(2R)-2-[2-(hydroxyamino)-2-keto-ethyl]-N-[(1S)-2-methyl-1-[(2S)-2-methylolpyrrolidine-1-carbonyl]propyl]enanthamide
18 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • Ambeed
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0161-M005
  • Product descriptionActinonin >97.0%(HPLC)
  • Packaging5mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA236595
  • Product descriptionActinonin 95%
  • Packaging1mg
  • Price$76
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3331
  • Product descriptionActinonin
  • Packaging25mg
  • Price$516
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3331
  • Product descriptionActinonin
  • Packaging5mg
  • Price$121
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546076
  • Product descriptionActinonin >98%
  • Packaging1mg
  • Price$127.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546076
  • Product descriptionActinonin >98%
  • Packaging5mg
  • Price$290.7
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16605
  • Product descriptionActinonin ≥98%
  • Packaging25mg
  • Price$476
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16605
  • Product descriptionActinonin ≥98%
  • Packaging5mg
  • Price$113
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0064758
  • Product descriptionActinonin 99.30%
  • Packaging5mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0064758
  • Product descriptionActinonin 99.30%
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0064758
  • Product descriptionActinonin 99.30%
  • Packaging25mg
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0064758
  • Product descriptionActinonin 99.30%
  • Packaging50mg
  • Price$680
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0064758
  • Product descriptionActinonin 99.30%
  • Packaging100mg
  • Price$1150
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11291128
  • Product descriptionActinonin 95+%
  • Packaging100mg
  • Price$743
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number6250
  • Product description(-)-Actinonin
  • Packaging50mg
  • Price$2000
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number6250
  • Product description(-)-Actinonin
  • Packaging10mg
  • Price$875
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0161-M005 Actinonin >97.0%(HPLC) 5mg $98 2021-12-16 Buy
Ambeed A236595 Actinonin 95% 1mg $76 2021-12-16 Buy
ApexBio Technology C3331 Actinonin 25mg $516 2021-12-16 Buy
ApexBio Technology C3331 Actinonin 5mg $121 2021-12-16 Buy
Biorbyt Ltd orb546076 Actinonin >98% 1mg $127.5 2021-12-16 Buy
Biorbyt Ltd orb546076 Actinonin >98% 5mg $290.7 2021-12-16 Buy
Cayman Chemical 16605 Actinonin ≥98% 25mg $476 2024-03-01 Buy
Cayman Chemical 16605 Actinonin ≥98% 5mg $113 2024-03-01 Buy
ChemScene CS-0064758 Actinonin 99.30% 5mg $100 2021-12-16 Buy
ChemScene CS-0064758 Actinonin 99.30% 10mg $180 2021-12-16 Buy
ChemScene CS-0064758 Actinonin 99.30% 25mg $380 2021-12-16 Buy
ChemScene CS-0064758 Actinonin 99.30% 50mg $680 2021-12-16 Buy
ChemScene CS-0064758 Actinonin 99.30% 100mg $1150 2021-12-16 Buy
Crysdot CD11291128 Actinonin 95+% 100mg $743 2021-12-16 Buy
Medical Isotopes, Inc. 6250 (-)-Actinonin 50mg $2000 2021-12-16 Buy
Medical Isotopes, Inc. 6250 (-)-Actinonin 10mg $875 2021-12-16 Buy

Properties

Melting point :137-139°C
Density :1.139±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
pka :9.19±0.20(Predicted)
form :White to off-white powder.
color :White
BRN :1555250
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
CAS DataBase Reference :13434-13-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-2 (IC50 = ~90 nM), MMP-3 (Ki = 1,700 nM), MMP-7 (IC50 = ~3,500 nM), MMP-8 (Ki = 130 nM), MMP-9 (Ki = 330 nM), MMP-10 (IC50 = ~500 nM), MMP-12 (IC50 = ~350 nM), and MMP-13 (IC50 = ~100 nM), but not MMP-14 (IC50 > 1 mM). Actinonin acts as an herbicide by targeting plastid peptide deformylase, an enzyme required for N-terminal processing of plastid-encoded proteins. Actinonin has also been identified as an effective inhibitor of human meprin α (Ki = 20 nM), a zinc endopeptidase that cleaves matrix proteins. More recently actinonin has been shown to inhibit tumor cell invasion and matrix degradation and to induce apoptosis in animal models by targeting human mitochondrial peptide deformylase.

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