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ChemicalBook >> CAS DataBase List >> Ranolazine dihydrochloride

Ranolazine dihydrochloride

Ranolazine dihydrochloride price.
  • $19 - $945.95
  • Product name: Ranolazine dihydrochloride
  • CAS: 95635-56-6
  • MF: C24H35Cl2N3O4
  • MW: 500.46
  • EINECS:
  • MDL Number:MFCD03788770
  • Synonyms:(+/-)-4-[2-HYDROXY-3-(O-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETO-2',6'-XYLIDIDE DIHYDROCHLORIDE;n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride;(+/-)-N-(2,6-DIMETHYLPHENYL)-4-[2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETAMIDE DIHYDROCHLORIDE;RANOLAZINE DIHYDROCHLORIDE;RANOLAZINE HCL;Ranolazine DiHCI ;Ranolazine and salt;N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)-propyl)piperazin-1-yl)acetamide di
35 prices
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Brand
  • AHH
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • AvaChem
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 50MG
  • 0.1g
  • 200mg
  • 500mg
  • 10mg
  • 100mg
  • 250mg
  • 50
  • 1g
  • 5g
  • 10mM(in 1mL DMSO)
  • ManufacturerAHH
  • Product numberAPI-1614
  • Product descriptionRanolazine Dihydrochloride 98%
  • Packaging1g
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberR463
  • Product descriptionRanolazine Dihydrochloride
  • Packaging1g
  • Price$229
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA730331
  • Product descriptionN-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamidedihydrochloride 98%
  • Packaging100mg
  • Price$19
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA730331
  • Product descriptionN-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamidedihydrochloride 98%
  • Packaging250mg
  • Price$29
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA730331
  • Product descriptionN-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamidedihydrochloride 98%
  • Packaging1g
  • Price$73
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA730331
  • Product descriptionN-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamidedihydrochloride 98%
  • Packaging5g
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004041
  • Product descriptionRANOLAZINE DIHYDROCHLORIDE 95.00%
  • Packaging1G
  • Price$945.95
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004041
  • Product descriptionRANOLAZINE DIHYDROCHLORIDE 95.00%
  • Packaging50MG
  • Price$184.8
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5300
  • Product descriptionRanolazine2HCl
  • Packaging10mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5300
  • Product descriptionRanolazine2HCl
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA5300
  • Product descriptionRanolazine2HCl
  • Packaging100mg
  • Price$53
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA5300
  • Product descriptionRanolazine2HCl
  • Packaging200mg
  • Price$88
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2451
  • Product descriptionRanolazine Dihydrochloride
  • Packaging100mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15604
  • Product descriptionRanolazine (hydrochloride) ≥98%
  • Packaging50mg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15604
  • Product descriptionRanolazine (hydrochloride) ≥98%
  • Packaging100mg
  • Price$137
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15604
  • Product descriptionRanolazine (hydrochloride) ≥98%
  • Packaging250mg
  • Price$298
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1614 Ranolazine Dihydrochloride 98% 1g $360 2021-12-16 Buy
AK Scientific R463 Ranolazine Dihydrochloride 1g $229 2021-12-16 Buy
Ambeed A730331 N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamidedihydrochloride 98% 100mg $19 2021-12-16 Buy
Ambeed A730331 N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamidedihydrochloride 98% 250mg $29 2021-12-16 Buy
Ambeed A730331 N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamidedihydrochloride 98% 1g $73 2021-12-16 Buy
Ambeed A730331 N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamidedihydrochloride 98% 5g $250 2021-12-16 Buy
American Custom Chemicals Corporation API0004041 RANOLAZINE DIHYDROCHLORIDE 95.00% 1G $945.95 2021-12-16 Buy
American Custom Chemicals Corporation API0004041 RANOLAZINE DIHYDROCHLORIDE 95.00% 50MG $184.8 2021-12-16 Buy
ApexBio Technology A5300 Ranolazine2HCl 10mg $44 2021-12-16 Buy
ApexBio Technology A5300 Ranolazine2HCl 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A5300 Ranolazine2HCl 100mg $53 2021-12-16 Buy
ApexBio Technology A5300 Ranolazine2HCl 200mg $88 2021-12-16 Buy
AvaChem 2451 Ranolazine Dihydrochloride 100mg $35 2021-12-16 Buy
Cayman Chemical 15604 Ranolazine (hydrochloride) ≥98% 50mg $81 2024-03-01 Buy
Cayman Chemical 15604 Ranolazine (hydrochloride) ≥98% 100mg $137 2024-03-01 Buy
Cayman Chemical 15604 Ranolazine (hydrochloride) ≥98% 250mg $298 2024-03-01 Buy

Properties

Melting point :222-229.5 °C(lit.)
storage temp. :Desiccate at RT
solubility :H2O: 10 mg/mL, soluble
form :solid
color :off-white
Merck :14,8111
Stability :Hygroscopic
CAS DataBase Reference :95635-56-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Ranolazine was developed to protect the heart from transient ischemia, as may occur during angina and infarct. It has diverse effects at the cellular level, inhibiting late sodium and potassium currents (IC50s = 3.9-16.6 μM for both) and blocking ligand binding to α1, β1, and β2 adrenergic receptors (Kis = 0.5-19.5 μM for all). Ranolazine inhibits fatty acid β-oxidation leading to decreased acetyl CoA, activation of pyruvate dehydrogenase, and increased glucose oxidation. It also weakly inhibits mitochondrial respiratory complex I.

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