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ChemicalBook >> CAS DataBase List >> Promethazine hydrochloride

Promethazine hydrochloride

Promethazine hydrochloride  price.
  • $10 - $618
  • Product name: Promethazine hydrochloride
  • CAS: 58-33-3
  • MF: C17H21ClN2S
  • MW: 320.88
  • EINECS:200-375-2
  • MDL Number:MFCD00012652
  • Synonyms:10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HYDROCHLORIDE;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride ;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride ;promethazinen-(2’-dimethylamino-2’-methylethyl)phenothiazinehydrochloride ;promethiazin ;pyrethia ;romegranhydrochloride
33 prices
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  • AHH
  • AK Scientific
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • CSNpharm
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
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Package
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  • p3400000
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  • ManufacturerAHH
  • Product numberMT-21657
  • Product descriptionPromethazine Hydrochloride 97%
  • Packaging5g
  • Price$618
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH509
  • Product descriptionPromethazine Hydrochloride
  • Packaging100g
  • Price$157
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS526908
  • Product descriptionPromethazine Hydrochloride ≥99%
  • Packaging250mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS526908
  • Product descriptionPromethazine Hydrochloride ≥99%
  • Packaging1g
  • Price$23
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS526908
  • Product descriptionPromethazine Hydrochloride ≥99%
  • Packaging5g
  • Price$60
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberBP166198
  • Product descriptionPromethazine hydrochloride
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
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  • ManufacturerCayman Chemical
  • Product number22450
  • Product descriptionPromethazine (hydrochloride) ≥98%
  • Packaging5mg
  • Price$20
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number21331
  • Product descriptionPromethazine (hydrochloride) (CRM)
  • Packaging1mg
  • Price$25
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number16478
  • Product descriptionPromethazine (hydrochloride) ≥95%
  • Packaging10g
  • Price$32
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number22450
  • Product descriptionPromethazine (hydrochloride) ≥98%
  • Packaging10mg
  • Price$34
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number16478
  • Product descriptionPromethazine (hydrochloride) ≥95%
  • Packaging25g
  • Price$53
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number16478
  • Product descriptionPromethazine (hydrochloride) ≥95%
  • Packaging50g
  • Price$93
  • Updated2024-03-01
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  • ManufacturerChem-Impex
  • Product number38172
  • Product descriptionPromethazinehydrochloride,98%(Assaybytitration,HPLC) 98%(Assaybytitration,HPLC)
  • Packaging25G
  • Price$49.28
  • Updated2021-12-16
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  • ManufacturerChem-Impex
  • Product number38172
  • Product descriptionPromethazinehydrochloride,98%(Assaybytitration,HPLC) 98%(Assaybytitration,HPLC)
  • Packaging100G
  • Price$165.76
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-3543
  • Product descriptionPromethazine Hydrochloride ≥98.0%
  • Packaging500mg
  • Price$50
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-3543
  • Product descriptionPromethazine Hydrochloride ≥98.0%
  • Packaging1g
  • Price$60
  • Updated2021-12-16
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Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-21657 Promethazine Hydrochloride 97% 5g $618 2021-12-16 Buy
AK Scientific H509 Promethazine Hydrochloride 100g $157 2021-12-16 Buy
Arctom AS526908 Promethazine Hydrochloride ≥99% 250mg $10 2021-12-16 Buy
Arctom AS526908 Promethazine Hydrochloride ≥99% 1g $23 2021-12-16 Buy
Arctom AS526908 Promethazine Hydrochloride ≥99% 5g $60 2021-12-16 Buy
Biosynth Carbosynth BP166198 Promethazine hydrochloride 100mg $50 2021-12-16 Buy
Cayman Chemical 22450 Promethazine (hydrochloride) ≥98% 5mg $20 2024-03-01 Buy
Cayman Chemical 21331 Promethazine (hydrochloride) (CRM) 1mg $25 2024-03-01 Buy
Cayman Chemical 16478 Promethazine (hydrochloride) ≥95% 10g $32 2024-03-01 Buy
Cayman Chemical 22450 Promethazine (hydrochloride) ≥98% 10mg $34 2024-03-01 Buy
Cayman Chemical 16478 Promethazine (hydrochloride) ≥95% 25g $53 2024-03-01 Buy
Cayman Chemical 16478 Promethazine (hydrochloride) ≥95% 50g $93 2024-03-01 Buy
Chem-Impex 38172 Promethazinehydrochloride,98%(Assaybytitration,HPLC) 98%(Assaybytitration,HPLC) 25G $49.28 2021-12-16 Buy
Chem-Impex 38172 Promethazinehydrochloride,98%(Assaybytitration,HPLC) 98%(Assaybytitration,HPLC) 100G $165.76 2021-12-16 Buy
ChemScene CS-3543 Promethazine Hydrochloride ≥98.0% 500mg $50 2021-12-16 Buy
ChemScene CS-3543 Promethazine Hydrochloride ≥98.0% 1g $60 2021-12-16 Buy

Properties

Melting point :230-232°C
Flash point :9℃
storage temp. :2-8°C
solubility :Very soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
form :Solid
color :White to Almost white
PH :pH (50g/L, 25℃) : 4.0~6.0
λmax :297nm(H2O)(lit.)
Merck :14,7786
BRN :4166397
BCS Class :1,3
InChI :InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
InChIKey :XXPDBLUZJRXNNZ-UHFFFAOYSA-N
SMILES :N1(CC(C)N(C)C)C2C=CC=CC=2SC2=CC=CC=C12.Cl
CAS DataBase Reference :58-33-3(CAS DataBase Reference)
EPA Substance Registry System :Promethazine hydrochloride (58-33-3)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively. Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.

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