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ChemicalBook >> CAS DataBase List >> 5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine

5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine

5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine price.
  • $31 - $4620
  • Product name: 5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine
  • CAS: 1224844-38-5
  • MF: C15H15N7O
  • MW: 309.33
  • EINECS:
  • MDL Number:MFCD22124893
  • Synonyms:5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine;3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;INK-128;3-(2-aminobenzo[d]oxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine;INK-128 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;MLN0128;5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine;-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine
45 prices
Selected condition：
Brand
  • Acrotein
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
Package
  • 5MG
  • 10mM(in 1mL DMSO)
  • 1MG
  • 10mg
  • 25mg
  • 50mg
  • 0.1g
  • 100mg
  • 200mg
  • 0.25g
  • 250mg
  • 500mg
  • 1g
  • 1000mg
  • 2g
  • ManufacturerAcrotein
  • Product numberUT00151
  • Product description5-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine 97%
  • Packaging0.1g
  • Price$183.33
  • Updated2021-12-16
  • Buy
  • ManufacturerAcrotein
  • Product numberUT00151
  • Product description5-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine 97%
  • Packaging0.25g
  • Price$383.33
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1157-M010
  • Product descriptionMLN0128 ≥95%
  • Packaging10mg
  • Price$281
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2477AH
  • Product description3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • Packaging100mg
  • Price$211
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2477AH
  • Product description3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • Packaging250mg
  • Price$329
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2477AH
  • Product description3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • Packaging1g
  • Price$784
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0013722
  • Product description3-(2-AMINO-5-BENZOXAZOLYL)-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 95.00%
  • Packaging1MG
  • Price$222.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0013722
  • Product description3-(2-AMINO-5-BENZOXAZOLYL)-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 95.00%
  • Packaging5MG
  • Price$500.81
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8551
  • Product descriptionINK128(MLN0128)
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8551
  • Product descriptionINK128(MLN0128)
  • Packaging10mM(in 1mL DMSO)
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8551
  • Product descriptionINK128(MLN0128)
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60099
  • Product descriptionSapanisertib(MLN0128)
  • Packaging10mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2142
  • Product descriptionINK128 99%
  • Packaging5mg
  • Price$121
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546175
  • Product descriptionINK-128 >98%
  • Packaging5mg
  • Price$147.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546175
  • Product descriptionINK-128 >98%
  • Packaging25mg
  • Price$241.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181035
  • Product descriptionINK-128 >98%
  • Packaging100mg
  • Price$690.2
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Acrotein UT00151 5-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine 97% 0.1g $183.33 2021-12-16 Buy
Acrotein UT00151 5-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine 97% 0.25g $383.33 2021-12-16 Buy
Adipogen Life Sciences SYN-1157-M010 MLN0128 ≥95% 10mg $281 2021-12-16 Buy
AK Scientific 2477AH 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 100mg $211 2021-12-16 Buy
AK Scientific 2477AH 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 250mg $329 2021-12-16 Buy
AK Scientific 2477AH 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1g $784 2021-12-16 Buy
American Custom Chemicals Corporation API0013722 3-(2-AMINO-5-BENZOXAZOLYL)-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 95.00% 1MG $222.6 2021-12-16 Buy
American Custom Chemicals Corporation API0013722 3-(2-AMINO-5-BENZOXAZOLYL)-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 95.00% 5MG $500.81 2021-12-16 Buy
ApexBio Technology A8551 INK128(MLN0128) 5mg $80 2021-12-16 Buy
ApexBio Technology A8551 INK128(MLN0128) 10mM(in 1mL DMSO) $90 2021-12-16 Buy
ApexBio Technology A8551 INK128(MLN0128) 10mg $100 2021-12-16 Buy
Arctom CFN60099 Sapanisertib(MLN0128) 10mg $238 2021-12-16 Buy
Axon Medchem Axon2142 INK128 99% 5mg $121 2021-12-16 Buy
Biorbyt Ltd orb546175 INK-128 >98% 5mg $147.9 2021-12-16 Buy
Biorbyt Ltd orb546175 INK-128 >98% 25mg $241.4 2021-12-16 Buy
Biorbyt Ltd orb181035 INK-128 >98% 100mg $690.2 2021-12-16 Buy

Properties

Melting point :270-272°C (dec.)
Boiling point :598.8±60.0 °C(Predicted)
Density :1.64
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml)
pka :3.77±0.30(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
InChIKey :GYLDXIAOMVERTK-UHFFFAOYSA-N
SMILES :C1=NC(N)=C2C(C3=CC=C4OC(N)=NC4=C3)=NN(C(C)C)C2=N1

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The mammalian target of rapamycin (mTOR) is a kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival. INK128 is an inhibitor of TORC1/2, acting as a sub-nanomolar ATP-dependent inhibitor of mTOR kinase. It blocks the phosphorylation of downstream substrates of both TORC1 and TORC2. INK128 interferes with the growth of cell lines which are resistant to rapamycin and pan-PI3K inhibitors. Moreover, daily, oral administration of INK128 inhibits angiogenesis and tumor growth in several xenograft models. The effects of INK128 on gene expression also reduce invasion and metastasis.