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ChemicalBook >> CAS DataBase List >> CYCLOPAMINE

CYCLOPAMINE

CYCLOPAMINE price.
  • $23 - $2189
  • Product name: CYCLOPAMINE
  • CAS: 4449-51-8
  • MF: C27H41NO2
  • MW: 411.62
  • EINECS:
  • MDL Number:MFCD09878269
  • Synonyms:11-DEOXOJERVINE;CyclopaMine, froM VeratruM californiciM;CYCLOPAMINE;Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-;Cyclopamine 11-Deoxojervine (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol;Cyclopamine, >=98%;(3S,6AS,6bS,8aR,10S,12aS,13S,13aS,15aS,15bR)-10,13,14,15b-tetramethyl-1,2,3,4,6,6a,6b,7,7a,8a;11-DEOXYJERVINE
55 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • Usbiological
Package
  • 1MG
  • 5mg
  • 10mM(in 1mL DMSO)
  • 1unit
  • 1
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0028-M005
  • Product descriptionCyclopamine ≥98%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX0052
  • Product descriptionCyclopamine
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX0052
  • Product descriptionCyclopamine
  • Packaging10mg
  • Price$113
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX0052
  • Product descriptionCyclopamine
  • Packaging25mg
  • Price$247
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ61528
  • Product descriptionCyclopamine, 99%
  • Packaging25mg
  • Price$301
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ61528
  • Product descriptionCyclopamine, 99%
  • Packaging50mg
  • Price$441.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0005733
  • Product descriptionCYCLOPAMINE 95.00%
  • Packaging1MG
  • Price$445
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0005733
  • Product descriptionCYCLOPAMINE 95.00%
  • Packaging5MG
  • Price$455
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0005733
  • Product descriptionCYCLOPAMINE 95.00%
  • Packaging10MG
  • Price$475
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0005733
  • Product descriptionCYCLOPAMINE 95.00%
  • Packaging50MG
  • Price$775
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8340
  • Product descriptionCyclopamine
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8340
  • Product descriptionCyclopamine
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8340
  • Product descriptionCyclopamine
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8340
  • Product descriptionCyclopamine
  • Packaging10mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8340
  • Product descriptionCyclopamine
  • Packaging25mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS021254
  • Product description(2'R,3S,3'R,3a'S,6aS,6bS,6'S,7a'R,11aS,11bR)-3',6',10,11b-tetramethyl-1,2,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11,11a,11b-octadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-3-ol ≥98%
  • Packaging1mg
  • Price$27
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0028-M005 Cyclopamine ≥98% 5mg $50 2021-12-16 Buy
AK Scientific X0052 Cyclopamine 5mg $75 2021-12-16 Buy
AK Scientific X0052 Cyclopamine 10mg $113 2021-12-16 Buy
AK Scientific X0052 Cyclopamine 25mg $247 2021-12-16 Buy
Alfa Aesar J61528 Cyclopamine, 99% 25mg $301 2024-03-01 Buy
Alfa Aesar J61528 Cyclopamine, 99% 50mg $441.65 2024-03-01 Buy
American Custom Chemicals Corporation PXT0005733 CYCLOPAMINE 95.00% 1MG $445 2021-12-16 Buy
American Custom Chemicals Corporation PXT0005733 CYCLOPAMINE 95.00% 5MG $455 2021-12-16 Buy
American Custom Chemicals Corporation PXT0005733 CYCLOPAMINE 95.00% 10MG $475 2021-12-16 Buy
American Custom Chemicals Corporation PXT0005733 CYCLOPAMINE 95.00% 50MG $775 2021-12-16 Buy
ApexBio Technology A8340 Cyclopamine 1unit $28 2021-12-16 Buy
ApexBio Technology A8340 Cyclopamine 5mg $50 2021-12-16 Buy
ApexBio Technology A8340 Cyclopamine 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A8340 Cyclopamine 10mg $65 2021-12-16 Buy
ApexBio Technology A8340 Cyclopamine 25mg $100 2021-12-16 Buy
Arctom AS021254 (2'R,3S,3'R,3a'S,6aS,6bS,6'S,7a'R,11aS,11bR)-3',6',10,11b-tetramethyl-1,2,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11,11a,11b-octadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-3-ol ≥98% 1mg $27 2021-12-16 Buy

Properties

Melting point :236-238°C
Boiling point :531.29°C (rough estimate)
Density :1.0274 (rough estimate)
refractive index :1.6400 (estimate)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
pka :15.05±0.70(Predicted)
color :White
Stability :Store in Freezer at - 20°C

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Description

Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened. By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia. As a readout of action, cyclopamine inhibits hedgehog-dependent expression of Pax7 with an IC50 value of 24 nM. Although teratogenic during development, cyclopamine has potential applications in the treatment of cancer.

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