AG 490
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- $32 - $2885
- Product name: AG 490
- CAS: 133550-30-8
- MF: C17H14N2O3
- MW: 294.3
- EINECS:
- MDL Number:MFCD00236452
- Synonyms:Zinc02557947;AG-490 (Tyrphostin B42);(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide AG-490(Tyrphostin B42);Tyrphostin AG 490 AG 490;AG 490, >=98%;(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide;AG490,AG-490;2-CYANO-3-[3,4-DIHYDROXYPHENYL]-N-[PHENYLMETHYL]-2-PROPENAMIDE
39 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 5mg
- 10mg
- 20mg
- 25MG
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- 5g
- 25g
- 500g
- ManufacturerAK Scientific
- Product numberX7479
- Product description(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
- Packaging20mg
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA205043
- Product description(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide 98+%
- Packaging10mg
- Price$48
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA205043
- Product description(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide 98+%
- Packaging50mg
- Price$106
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA205043
- Product description(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide 98+%
- Packaging250mg
- Price$178
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA205043
- Product description(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide 98+%
- Packaging1g
- Price$344
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000029
- Product descriptionAG 490 95.00%
- Packaging25MG
- Price$721.88
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000029
- Product descriptionAG 490 95.00%
- Packaging250MG
- Price$1732.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4139
- Product descriptionAG 490
- Packaging25mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60113
- Product descriptionTyrphostinB42(AG-490) ≥98%
- Packaging20mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1378
- Product descriptionAG490-TyrphostinAG490|TyrphostinB42 99%
- Packaging10mg
- Price$71.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB43343
- Product description(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
- Packaging25mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB43343
- Product description(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
- Packaging50mg
- Price$325
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB43343
- Product description(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
- Packaging100mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB43343
- Product description(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
- Packaging250mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB43343
- Product description(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
- Packaging500g
- Price$1000
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10010311
- Product descriptionAG 490 ≥98%
- Packaging5mg
- Price$32
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7479 | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | 20mg | $149 | 2021-12-16 | Buy |
| Ambeed | A205043 | (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide 98+% | 10mg | $48 | 2021-12-16 | Buy |
| Ambeed | A205043 | (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide 98+% | 50mg | $106 | 2021-12-16 | Buy |
| Ambeed | A205043 | (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide 98+% | 250mg | $178 | 2021-12-16 | Buy |
| Ambeed | A205043 | (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide 98+% | 1g | $344 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000029 | AG 490 95.00% | 25MG | $721.88 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000029 | AG 490 95.00% | 250MG | $1732.5 | 2021-12-16 | Buy |
| ApexBio Technology | A4139 | AG 490 | 25mg | $60 | 2021-12-16 | Buy |
| Arctom | CFN60113 | TyrphostinB42(AG-490) ≥98% | 20mg | $108 | 2021-12-16 | Buy |
| Axon Medchem | Axon1378 | AG490-TyrphostinAG490|TyrphostinB42 99% | 10mg | $71.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB43343 | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | 25mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB43343 | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | 50mg | $325 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB43343 | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | 100mg | $500 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB43343 | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | 250mg | $750 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB43343 | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | 500g | $1000 | 2021-12-16 | Buy |
| Cayman Chemical | 10010311 | AG 490 ≥98% | 5mg | $32 | 2024-03-01 | Buy |
Properties
Melting point :215°C(lit.)
Boiling point :615.2±55.0 °C(Predicted)
Density :1.337
storage temp. :-20°C
solubility :ethanol: 5 mg/mL
form :solid
pka :8.75±0.10(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.
InChIKey :TUCIOBMMDDOEMM-ZSOIEALJSA-N
Boiling point :615.2±55.0 °C(Predicted)
Density :1.337
storage temp. :-20°C
solubility :ethanol: 5 mg/mL
form :solid
pka :8.75±0.10(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.
InChIKey :TUCIOBMMDDOEMM-ZSOIEALJSA-N
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Tyrphostin AG 490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, Tyrphostin AG 490 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, Tyrphostin AG 490 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that Tyrphostin AG 490 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by Tyrphostin AG 490 leads to lower levels of p85 phosphorylation and p-13 kinase activation.Related product price
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