(R)-(+)-Glycidol
Product identifier
- Product name: (R)-(+)-Glycidol
- CBnumber: CB5205831
- CAS: 57044-25-4
- EINECS Number: 404-660-4
- Synonyms: (R)-oxiran-2-ylmethanol,(R)-glycidol
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: (R)-(+)-Glycidol
- Synonyms: (R)-oxiran-2-ylmethanol,(R)-glycidol
- CAS: 57044-25-4
- EC number: 404-660-4
- MF: C3H6O2
- MW: 74.08
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Notes to physician
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary. Use water spray to cool unopened containers.
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local / national regulations (see section 13). Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Recommended storage temperature -20 °C Moisture sensitive.
control parameter
Hazard composition and occupational exposure limitsExposure controls
Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye
protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Information on basic physicochemical properties
- Appearancelight yellow clear, liquid
- Odourodorless
- Odour ThresholdNo data available
- pHNo data available
- Melting point/freezing pointNo data available
- Initial boiling point and boiling range 56 - 57 °C at 15 hPa - lit.
- Flash point72 °C at ca.1,013.25 hPa
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limitsNo data available
- Vapour pressure 1.2 hPa at 25 °C
- Vapour density No data available
- Relative density1.116 g/cm3 at 20 °C
- Water solubilitycompletely miscible
- Partition coefficient: n-octanol/waterNo data available
- Autoignition temperature415 °C at 1,013.25 hPa
- Decomposition temperatureType C
- ViscosityNo data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
No data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
Heat, flames and sparks.
Incompatible materials
Strong acids, Strong bases, Heavy metals, Heavy metal salts, Strong oxidizing agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available
In the event of fire: see section 5
Information on toxicological effects
Acute toxicityLC50 Inhalation - Mouse - male - 4 h - 1.37 mg/l Remarks: (ECHA)
LC50 Inhalation - Rat - male - 4 h - 2.22 mg/l Remarks: (ECHA)
LC50 Inhalation - Rat - 4 h - 1.26 mg/l Remarks: (RTECS)
LD50 Dermal - Rabbit - 1,980 mg/kg Remarks: (RTECS)
Result: Skin irritation Remarks: (RTECS)
(Regulation (EC) No 1272/2008, Annex VI)
Result: Causes serious eye irritation. - 48 h Remarks: (ECHA)
(Regulation (EC) No 1272/2008, Annex VI)
Salmonella typhimurium Result: positive
(ECHA)
Rat - male and female
Result: Positive results were obtained in some in vivo tests. (ECHA)
Rat - male and female
Result: Positive results were obtained in some in vivo tests. (ECHA)
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Subchronic toxicity
RTECS: RR0508000
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea, Central nervous system depression
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Toxicity
No data available
144.7 mg/l - 96 h
Remarks: (ECHA)((R)-2,3-epoxy-1-propanol)
Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 94 % - Readily biodegradable. Remarks: (ECHA)
Bioaccumulative potential
No data available
Mobility in soil
No data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
No data available
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.
UN number
ADR/RID: 2810 IMDG: 2810 IATA-DGR: 2810
UN proper shipping name
ADR/RID: TOXIC LIQUID, ORGANIC, N.O.S. ((R)-2,3-epoxy-1-propanol) IMDG: TOXIC LIQUID, ORGANIC, N.O.S. ((R)-2,3-epoxy-1-propanol)
IATA-DGR: Toxic liquid, organic, n.o.s. ((R)-2,3-epoxy-1-propanol)
Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA-DGR: 6.1
Packaging group
ADR/RID: III IMDG: III IATA-DGR: III
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA-DGR: no
Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport. Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Incompatible materials
Strong acids, Strong bases, Heavy metals, Heavy metal salts, Strong oxidizing agents
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.