Propylene oxide
Product identifier
- Product name: Propylene oxide
- CBnumber: CB9854235
- CAS: 75-56-9
- EINECS Number: 200-879-2
- Synonyms: Propylene Oxide,PO
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: Propylene oxide
- Synonyms: Propylene Oxide,PO
- CAS: 75-56-9
- EC number: 200-879-2
- MF: C3H6O
- MW: 58.08
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.
Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Further information
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 4 | Will rapidly or completely vaporize at normal atmospheric pressure and temperature, or is readily dispersed in air and will burn readily. Includes pyrophoric substances. Flash point below room temperature at 22.8 °C (73 °F). (e.g. acetylene, propane, hydrogen gas) | |
| REACT | 2 | Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.
Environmental precautions
Do not let product enter drains. Risk of explosion.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb?). Dispose of properly. Clean up affected area.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and
sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.
Over time, pressure may increase causing containers to burst Handle and open container with care. Heat sensitive. Cool to 0°C before opening.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentUse equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Splash contact Material: butyl-rubber
Minimum layer thickness: 0,3 mm Break through time: 26 min
Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Flame retardant antistatic protective clothing.
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type: Filter type AX
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Do not let product enter drains. Risk of explosion.
Information on basic physicochemical properties
- Appearancecolorless clear, liquid
- Odoursweet, ether-like
- Odour ThresholdNo data available
- pHNo data available
- Melting point/freezing pointMelting point/range: -112 °C - lit.
- Initial boiling point and boiling range 34 °C - lit.
- Flash point-38 °C - Equilibrium method - closed cup
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limits Upper explosion limit: 36 - 45 %(V) Lower explosion limit: 1,9 %(V)
- Vapour pressure 2.028,5 hPa at 55 °C
- Vapour density 2,01 - (Air = 1.0)
- Relative density0,83 g/mL at 25 °C - lit. 0,83 at 20 °C - Regulation (EC) No. 440/2008, Annex, A.3
- Water solubility425 g/l at 20 °C - OECD Test Guideline 105
- Partition coefficient: n-octanol/waterlog Pow: 0,03 - Bioaccumulation is not expected.
- Autoignition temperature >400 °C at 1.005 - 1.018 hPa - Tested according to Directive 92/69/EEC.
- Decomposition temperatureNo data available
- ViscosityViscosity, kinematic: 0,44 mm2/s at 0 °C - OECD Test Guideline 1140,37 mm2/s at 20 °C - OECD Test Guideline 114 Viscosity, dynamic: 0,32 mPa.s at 20 °C
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
- Henry's Law ConstantNot an environmentally important parameter because propylene oxide reacts rapidly with water
Other safety information
Surface tension 71,5 mN/m at 1,06g/l at 21 °C
- Surface tension
Relative vapor density
2,01 - (Air = 1.0)
Reactivity
Vapors may form explosive mixture with air.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Risk of ignition or formation of inflammable gases or vapours with: Hydrogen fluoride
Oxidizing agents Nitric acid
Risk of explosion with: polymerisation initiators Oxygen
Exothermic reaction with: Strong oxidizing agents Ammonia
halogens
alkali hydroxides polymerization alkalines
Amines metallic oxides
metallic chlorides chlorosulfonic acid Hydrogen chloride gas fuming sulfuric acid aluminium chloride acids
Conditions to avoid
Heat. Warming.
Incompatible materials
rubber, various plastics, Copper
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicityLC50 Inhalation - Rat - male and female - 4 h - 9,95 mg/l (OECD Test Guideline 403)
LD50 Dermal - Rabbit - 950 mg/kg Remarks: (ECHA)
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Result: Severe irritations (Draize Test)
Remarks: (RTECS)
Result: positive
Test Type: In vitro mammalian cell gene mutation test Test system: Mouse lymphoma test
Metabolic activation: without metabolic activation Method: OECD Test Guideline 476
Result: positive
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Metabolic activation: without metabolic activation
Method: OECD Test Guideline 473 Result: positive
Test Type: Mutagenicity (mammal cell test): micronucleus. Species: Rat
Cell type: Red blood cells (erythrocytes) Application Route: inhalation (vapor) Method: OECD Test Guideline 474 Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Species: Rat
Application Route: inhalation (vapor) Method: OECD Test Guideline 475 Result: negative
Toxicity
(US-EPA)
static test EC50 - Daphnia magna (Water flea) - 350 mg/l - 48 h (US-EPA)
(US-EPA)
Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 96 % - Readily biodegradable. (OECD Test Guideline 301C)
Bioaccumulative potential
Due to the distribution coefficient n-octanol/water, accumulation in organisms is not expected.
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Stability in water - 15,7 yr
Remarks: reaction with hydroxyl radicals(calculated)
- ca.11 d
Remarks: Hydrolysis
Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.
IncompatibilitiesVapors may form explosive mixture with air. Reacts with strong oxidizers, anhydrous metal chlor- ides; chlorine, iron, strong acids; caustics and peroxides. Polymerization may occur due to high temperatures or con- tamination with alkalis, aqueous acids; amines, metal chlor- ides; and acidic alcohols. Attacks some plastics, coatings and rubber.
Waste DisposalConcentrated waste contain- ing no peroxides-discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides- perforation of a container of the waste from a safe distance followed by open burning
UN number
UN proper shipping name
Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
Packaging group
ADR/RID: I IMDG: I IATA: I
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.