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Talanta

Talanta

IF: 5.59
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A “Four-in-One” Immunochromatographic Strip for Multi-Readout Detection of Diazepam in Lake Water and Fish via Nanozyme-Mediated Colorimetric, Catalytic, and Photothermal Activities

Published:22 November 2024 DOI: 10.1016/j.talanta.2024.127275
Fuyuan Zhang, Jing Wang, Xianghong Wang

Abstract

The presence of psychotropic drugs (PDs) in aquatic ecosystems represents an increasing environmental problem, posing a serious threat to human health and aquatic organisms. Lateral flow immunoassays (LFIA) have been widely used in the detection of PD contaminants. However, maintaining signaling tag reporting activity and achieving LFIA's multi-readout capability remain significant challenges to meeting a range of detection scenarios. Here, a rapid multifunctional LFIA has been developed for detecting diazepam (DAP), an emerging environmental and food safety PD contaminant, in lake water and fish samples. Copper hexacyanoferrate nanoparticles doped with Au and Pt (AuPt@Cu-HCF) were designed and manufactured as a multi-signal reporter with exceptional photothermal conversion efficiency and peroxidase-like enzymatic activity. This study integrates the colorimetric, photothermal, catalytic colorimetric, and catalytic photothermal effects of the AuPt@Cu-HCF nanozyme to form a “four-in-one” multi-readout LFIA. The multifunctional detection approach achieved four different detection signal outputs for DAP, with detection limits of 0.82?ng/mL, 12.82?pg/mL, 12.26?pg/mL, and 4.43?pg/mL for the basic colorimetric, photothermal, catalytic colorimetric, and colorimetric photothermal readout modes, respectively. This quadruplex-functional LFIA offers four different options with varying sensitivities and detection ranges, suitable for various application scenarios. It also allows multiple verifications for a single sample, enhancing detection accuracy.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Citric acid 77-92-9 C6H8O7 1796 suppliers $5.00-$2290.00
Sodium chloride 7647-14-5 ClNa 1214 suppliers $5.00-$6678.62
Polysorbate 20 9005-64-5 C26H50O10 656 suppliers $12.00-$6080.49
Copper(II) sulfate pentahydrate 7758-99-8 CuH10O9S 558 suppliers $6.00-$6468.00
Bovine albumin 9048-46-8 N/A 498 suppliers $15.00-$17060.00
Hydrogen tetrachloroaurate(III) trihydrate 16961-25-4 AuCl4H3O 244 suppliers $38.00-$2740.00

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