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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Fe-coordinated carbon dots with single atom nanozyme catalytic activity for synergistic catalytic/chemo-therapy in breast cancer

Published:1 December 2024 DOI: 10.1016/j.ijbiomac.2024.137776 PMID: 39577541
Mengke Lu, Jianxia Ding, Wei Zhang

Abstract

Single atom nanozyme (SAzyme) based on carbon dots (CDs) has showed great potential in oncotherapy via ultrasmall size-reinforced atomically dispersed catalytic sites. However, its curative effect is still unsatisfactory due to complex tumor microenvironment and intrinsic resistance. Herein, a coordinated carbon dots (CCDs)-integrated ZIF-8 nanoassembly (Ru/CCDs-PTX@ZIF) was constructed by loading paclitaxel and coating with rutin for synergistic catalytic/chemotherapy. Benefiting from inherited metal-polyphenol coordination, the CCDs exhibited superior peroxidase-like (POD) activity and served as a SAzyme to produce large amounts of hydroxyl radical, resulting in radical-dependent cell cycle arrest. With the assistance of GLUT receptor-mediated endocytosis, the Ru/CCDs-PTX@ZIF triggered the tumor-targeted killing and migration inhibition to suppress tumor progression. This study highlights a promising avenue to broaden the design and applications of CDs-based SAzyme in tumor treatment.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Dimethyl sulfoxide 67-68-5 C2H6OS 1342 suppliers $15.00-$120900.00
Paclitaxel 33069-62-4 C47H51NO14 1110 suppliers $30.00-$4200.00
Tannic acid 1401-55-4 C76H52O46 750 suppliers $10.00-$4499.30
Rutin 153-18-4 C27H30O16 717 suppliers $6.00-$569.50
Iron chloride hexahydrate 10025-77-1 Cl3FeH12O6 399 suppliers $10.00-$2790.00
FETUIN 9014-81-7 NULL 66 suppliers $37.07-$4380.00