鹽酸樂卡地平概述藥理作用用途MSDS用途與合成方法鹽酸樂卡地平價格(試劑級)上下游產(chǎn)品信息專題中文名稱:鹽酸樂卡地平中文同義詞:鹽酸樂卡地平;1,4-二氫-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸2-[(3,3-二苯丙基)甲基氨基]-1,1-二甲基乙基甲酯鹽酸鹽;樂卡地平雜質(zhì)1;樂卡地平鹽酸鹽(標準品);再寧平;鹽酸樂卡地平,≥98%(HPLC);BCL-10重組兔單克隆抗體英文名稱:Lercanidipinehydrochloride英文同義詞:1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethylmethylesterhydrochloride;LERCANIDIPINEHCL;LERCANIDIPINEHYDROCHLORIDE;1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylicAcid2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimeth;1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylicAcid2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethylMethylEsterHydrochloride;3-(1-((3,3-Diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl)5-methyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylatehydrochloride;3,5-Pyridinedicarboxylicacid,1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,3-[2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl]5-Methylester,hydrochloride(1:1);LercanidipineImpurity1CAS號:132866-11-6分子式:C36H42ClN3O6分子量:648.19EINECS號:603-682-3相關(guān)類別:醫(yī)藥降壓藥;醫(yī)藥中間體;醫(yī)藥原料;中間體;細胞信號和神經(jīng)生物學;原料藥;MiscellaneousNaturalProducts;DihydropyridineClassChemicals;Aromatics;Dihydropyridine;Heterocycles;細胞生物學;API;CardiovascularAPIs;生物活性小分子;對照品;對照品-雜質(zhì)對照品;醫(yī)用原料;Intermediates&FineChemicals;Pharmaceuticals;CalciumChannelModulators;InhibitorsandActivators;Voltage-gatedIonChannelsMol文件:132866-11-6.mol鹽酸樂卡地平性質(zhì)熔點175-177°C儲存條件2-8°C形態(tài)powder顏色yellowMerck14,5446InChIKeyWMFYOYKPJLRMJI-UHFFFAOYSA-NCAS數(shù)據(jù)庫132866-11-6(CASDataBaseReference)鹽酸樂卡地平用途與合成方法概述鹽酸樂卡地平為第三代二氫吡啶類鈣通道阻滯劑，其作用機制與同類藥物相似，即可逆地阻滯血管平滑肌細胞膜L型鈣通道的鈣離子內(nèi)流，擴張外周血管而降低血壓。藥理作用鹽酸樂卡地平為第三代二氫吡啶類鈣通道阻滯劑，其親脂性較高，起效時間較慢，作用時間較長，血漿達峰時間為2~3h，具有首過代謝的飽和性，食物可增加其吸收，吸收后迅速分布、積聚在細胞膜脂質(zhì)雙層，蛋白結(jié)合率高于98%。鹽酸樂卡地平主要由CYP3A4代謝，具有廣泛的首過效應，無活性代謝產(chǎn)物。50%由糞便排出，44%由尿液排出。用途長效鈣拮抗劑-鹽酸樂卡地平，其降壓療效肯定，同時具有腎臟保護作用，對血脂也有利。