L-蘋果酸|T4838

價格	￥178
包裝	1mL

最小起訂量	1mL
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:L-蘋果酸	英文名稱:(S)-Malic acid
CAS:97-67-6	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.86%	產(chǎn)品類別: 抑制劑
貨號: T4838

Product Introduction

Bioactivity

名稱	(S)-Malic acid
描述	(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. Apples contain malic acid, which contributes to the sourness of a green apple. Malic acid can make a wine taste tart, although the amount decreases with increasing fruit ripeness. (wikipedia). In its ionized form malic acid is called malate. Malate is an intermediate of the TCA cycle along with fumarate. It can also be formed from pyruvate as one of the anaplerotic reactions. In humans, malic acid is both derived from food sources and synthesized in the body through the citric acid cycle or Krebs cycle which takes place in the mitochondria. Malate's importance to the production of energy in the body during both aerobic and anaerobic conditions is well established. Under aerobic conditions, the oxidation of malate to oxaloacetate provides reducing equivalents to the mitochondria through the malate-aspartate redox shuttle. During anaerobic conditions, where a buildup of excess of reducing equivalents inhibits glycolysis, malic acid's simultaneous reduction to succinate and oxidation to oxaloacetate is capable of removing the accumulating reducing equivalents. This allows malic acid to reverse hypoxia's inhibition of glycolysis and energy production. In studies on rats it has been found that only tissue malate is depleted following exhaustive physical activity. Other key metabolites from the citric acid cycle needed for energy production were found to be unchanged. Because of this, a deficiency of malic acid has been hypothesized to be a major cause of physical exhaustion. Notably, the administration of malic acid to rats has been shown to elevate mitochondrial malate and increase mitochondrial respiration and energy production.
體外活性	研究表明，ME對于L. casei中(S)-Malic acid(L-蘋果酸)的利用是必要的。此外，如果刪除編碼組氨酸激酶或TC系統(tǒng)的應(yīng)答調(diào)節(jié)器的基因，會導(dǎo)致喪失在(S)-Malic acid上生長的能力，這說明相應(yīng)的TC系統(tǒng)調(diào)控并對ME的表達是必需的。轉(zhuǎn)錄分析顯示，maeE的表達在(S)-Malic acid存在的情況下被誘導(dǎo)，在葡萄糖存在的情況下被抑制，而TC系統(tǒng)的表達則是由(S)-Malic acid誘導(dǎo)并且不被葡萄糖抑制。
存儲條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 27.5 mg/mL (205.09 mM)
關(guān)鍵字	HYDROXYSUCCINIC ACID \| inhibit \| Inhibitor \| Malic acid \| (S)-Hydroxybutanedioic acid \| (S)-E 296 \| (S) Malic acid \| Endogenous Metabolite \| (S)-Malic acid \| 2-Hydroxysuccinic acid \| L-Malic acid \| (S)Malic acid
相關(guān)產(chǎn)品	Oleamide \| p-Hydroxybenzaldehyde \| Guanidine hydrochloride \| Naringin \| Daidzein \| Glycerol \| Sucrose \| Oxalic acid dihydrate \| Ferulic Acid \| 3-Indoleacetic acid \| Thymidine \| Fumaric acid
相關(guān)庫	微生物天然產(chǎn)物庫 \| 古代經(jīng)典名方目錄分子庫 \| 人內(nèi)源代謝化合物庫 \| 腸道微生物代謝化合物庫 \| 風(fēng)味化合物庫 \| 煙草單體化合物庫 \| 高通量篩選天然產(chǎn)物庫

關(guān)鍵字： L-蘋果酸|||L-(-)-Malic acid|||(S)-2-Hydroxysuccinic acid|||(S)-(-)-HYDROXYSUCCINIC ACID|TargetMol

公司簡介

上海陶術(shù)生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個性化定制合成；從對明確靶點的分子篩選到對明確分子的多靶點篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國市場五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊資本	566.2651萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場三路28號4樓

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