Progranulin產(chǎn)品信息

英文名稱：Progranulin

中文名稱：顆粒蛋白前體

靶點(diǎn)別稱：GRN

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 0.01 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

Progranulin分子背景

Progranulin是一種分泌型糖蛋白，在人類中由單個(gè)GRN基因編碼。Progranulin由12-半胱氨酸granulin基序的七個(gè)半串聯(lián)重復(fù)的不相同拷貝組成。許多細(xì)胞過程和疾病都與這種獨(dú)特的多效性因子有關(guān)，包括但不限于胚胎發(fā)生、腫瘤發(fā)生、炎癥、傷口修復(fù)、神經(jīng)變性和溶酶體功能。由GRN基因內(nèi)的常染色體顯性突變引起的半相合性導(dǎo)致額顳葉變性，這是一種進(jìn)行性神經(jīng)元萎縮，在患者中表現(xiàn)為額顳葉癡呆。