Rabbit Anti-Granulin Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Granulin
IR:Immunogen Range:451-550/593
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2896
Swiss Prot:P28799
Source:KLH conjugated synthetic peptide derived from human PGNR:451-550/593
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Rabbit
Guinea Pig
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： Granulin;Granulin Acrogranin;GEP;GP88;Granulin epithelin;GRN;PCDGF;Proepithelin;
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