中文名：SB-203580,p38 MAPK抑制劑

英文名：SB-203580

英文別名：152121-47-6|SB 203580|SB-203580|SB203580|4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole|Adezmapimod|4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine|4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-

純度：≥98%(HPLC)

貨號(hào)：S131899

包裝：100mg、5mg、25mg

Cas號(hào)：152121-47-6

存儲(chǔ)溫度：-20°C儲(chǔ)存

產(chǎn)品介紹：

SB203580是一種p38 MAPK抑制劑，在THP-1細(xì)胞中IC50為0.3-0.5 μM，對(duì)SAPK3(106T)和SAPK4(106T)選擇性低10倍，且阻斷PKB磷酸化，IC50為3-5 μMMDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.¹⁶ It was used to inhibit MAPK signaling in mouse cortical neurons¹⁷ and human hepatocellular carcinoma cell lines.¹⁸

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