Topotecan hydrochloride NEW
| Price | $30 | $47 | $73 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Topotecan hydrochloride | CAS No.: 119413-54-6 |
| Purity: 98.71% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Topotecan hydrochloride |
| Description | Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer. |
| Cell Research | Topotecan is dissolved in sterile water to a stock concentration of 1 mg/mL, diluted to 6 μg/mL in cultured medium and then serially diluted 1:4 in opaque, white tissue culture-treated microplates to a final volume of 0.1 mL/well. MCF-7 Luc and DU-145 Luc cells are resuspended in 3×104 cells/mL in DMEM with high glucose containing 10% FBS and 0.5 mg/mL Geneticin; 100 μL of cells are added in each well. Plates are incubated for 4 days at 37 °C in 95% humidity/5% CO2. After incubation, 0.05 mL of 0.1 M HEPES buffer (pH 7.9) containing 50 μg/mL D-luciferin is added to each well. After incubation at room temperature for 10 minutes, the culture microplate is measured in a microplate luminometer and a molecular light imager. Results obtained with the microplate luminometer are calculated using no inhibition control wells without exogenous drug and maximum inhibition control wells containing ATP inhibitor. Results for the molecular light imager are similarly calculated using values obtained with a 5 minutes luminescent imager. (Only for Reference) |
| In vitro | Topotecan induces effective anti-leukemic activity in a severe combined immunodeficient (SCID) mouse model of poor-prognosis acute lymphoblastic leukemia (ALL). Its administration significantly prolongs the disease-free survival in SCID mice challenged with a lethal dose of human leukemia cells at systemic drug exposure levels. Glioblastomas preferentially express TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), and Topotecan treatment notably upregulates this expression. Furthermore, when DU-145 Luc cells are subcutaneously implanted and treated with Topotecan, significant tumor growth inhibition and regression are observed via caudal vein injection and bioluminescent imaging. |
| In vivo | In radiation-resistant human B-lineage acute lymphoblastic leukemia cells, Topotecan stabilizes topoisomerase I/DNA cleavable complexes, inducing rapid apoptosis regardless of high bcl-2 protein expression, and inhibits clonal growth of the cells in a dose-dependent manner. Topotecan exhibits augmented drug activity against DU-145 Luc and MCF-7 Luc cells. During DNA replication, its cytotoxic action is mediated by stabilizing the covalent complex between topoisomerase I and DNA, preventing religation of the enzyme-linked single-strand DNA breaks. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 45.8 mg/mL (100 mM) DMSO : 55 mg/mL (120.11 mM) |
| Keywords | Topoisomerase | NSC609669 | NSC-609699 | Inhibitor | Topotecan hydrochloride | NSC 609699 | NSC-609669 | Topotecan Hydrochloride | inhibit | Autophagy | Apoptosis | Topotecan |
| Inhibitors Related | Hydroxychloroquine | Guanidine hydrochloride | Tributyrin |
| Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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