Product Details
| Product Name:
Patritumab |
CAS No.:
1262787-83-6 |
| Purity:
98.2% (SEC-HPLC) |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Patritumab |
| 描述 | Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritumab promotes apoptosis and inhibits proliferation in non-small cell lung cancer. |
| 體外活性 | Patritumab targets the extracellular domain (ECD) of HER3 and induces apoptosis in DiFi-HRG4 cells (10 μg/mL; 5 days)[1]. Patritumab (10 μg/mL; 6 h) markedly inhibits the phosphorylation of HER3 and AKT in DiFi-HRG4 cells without affecting that of ERK[1]. Additionally, Patritumab (10 μg/mL; 48 h) induces the cleavage of PARP, accompanied by both up-regulation of BIM and down-regulation of survivin expression[1]. |
| 體內(nèi)活性 | In a DiFi-HRG tumor xenografts model in mice, Patritumab (1 mg/mouse; intraperitoneal; twice a week for 4 weeks) combines with 1 mg Cetuximab and restores Cetuximab sensitivity[1]. Heregulin produced by colorectal cancer tumors harboring wild-type KRAS induces Cetuximab resistance, and combination therapy with cetuximab and patritumab overcomes such resistance in vivo[1]. |
| 存儲(chǔ)條件 | store at low temperature | store at -20°C | Shipping with blue ice. |
| 相關(guān)產(chǎn)品 | TBHQ | Osimertinib | Lidocaine | Astragaloside IV | Lapatinib | Lidocaine hydrochloride | Artemisinin | Erlotinib | Neratinib | Tauroursodeoxycholate | Gefitinib | 2,3-Butanediol |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$3480.00/10mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
United States