XL413 hydrochloride NEW
| Price | $48 | $117 | $163 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: XL413 hydrochloride | CAS No.: 2062200-97-7 |
| Purity: 99.82% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | XL413 hydrochloride |
| Description | XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM1, respectively, and an EC 50 of 118 nM on pMCM. |
| In vitro | XL413 (BMS-863233) hydrochloride effectively inhibits cell proliferation (IC 50 = 2685 nM), reduces cell viability (IC 50 = 2142 nM), and increases caspase 3/7 activity (EC 50 = 2288 nM) in Colo-205 cells. Additionally, it significantly suppresses the anchorage-independent growth of Colo-205 cells in soft agar (IC 50 = 715 nM) [1]. Demonstrating cytotoxic effects, XL413 hydrochloride has IC 50 values of 22.9 μM in HCC1954 cells and 1.1 μM in Colo-205 cells. It triggers apoptosis in Colo-205 cells without affecting HCC1954 cells. As a DDK inhibitor, XL413 shows potent activity in vitro (IC 50 = 22.7 nM), yet fails to inhibit DDK-dependent Mcm2 phosphorylation in HCC1954 cells, while remaining effective in Colo-205 cells [2]. |
| In vivo | XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride shows excellent plasma exposure and favorable pharmacokinetic properties in mice. Additionally, XL413 hydrochloride (10, 30, or 100 mg/kg, p.o.) is well tolerated at all tested doses without significant body weight loss [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 2.5 mg/mL (7.66 mM) H2O : 4.76 mg/mL (14.6 mM), Sonication is recommended. |
| Keywords | XL-413 hydrochloride | XL 413 Hydrochloride | XL413 hydrochloride | BMS 863233 Hydrochloride | BMS863233 Hydrochloride | BMS863233 | XL 413 | XL-413 Hydrochloride | XL-413 | XL413 Hydrochloride | BMS 863233 |
| Inhibitors Related | Ribociclib | Ro-3306 | Emodin | Palbociclib monohydrochloride | N-Cbz-DL-tryptophan | CASIN | Palbociclib | GW 441756 | Sodium Oxamate | Abemaciclib | Dinaciclib | Abemaciclib methanesulfonate |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Liver Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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