ALSTONINE
| 中文名稱 | ALSTONINE |
|---|---|
| 中文同義詞 | 鴨腳木堿,雞骨常山堿 |
| 英文名稱 | Indole alkaloid |
| 英文同義詞 | Aids002662;Aids-002662;3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19.alpha.-methyl-20.alpha.- oxayohimbanium;Oxayohimbanium,3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyl-, inner salt, (19a,20a)- |
| CAS號(hào) | 642-18-2 |
| 分子式 | C21H20N2O3 |
| 分子量 | 348.4 |
| EINECS號(hào) | |
| 相關(guān)類別 | 生物堿;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品 |
| Mol文件 | 642-18-2.mol |
| 結(jié)構(gòu)式 |  |
ALSTONINE 性質(zhì)
| 儲(chǔ)存條件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 白色至黃色 |
Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues.
In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg.
Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages.
Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells.