準(zhǔn)葛爾烏頭堿
| 中文名稱(chēng) | 準(zhǔn)葛爾烏頭堿 |
|---|---|
| 中文同義詞 | 準(zhǔn)葛爾烏頭堿;雪上一枝蒿 G;宋果靈(準(zhǔn)格爾烏頭堿);宋果靈(華北烏頭堿、一枝蒿庚素;準(zhǔn)噶爾烏頭堿;準(zhǔn)格爾烏頭堿;華北烏頭堿;宋果靈(華北烏頭堿、一枝蒿庚素)(標(biāo)準(zhǔn)品) |
| 英文名稱(chēng) | songorine |
| 英文同義詞 | (20R)-21-Ethyl-1α,15β-dihydroxy-4-methyl-16-methylene-7α,20-cycloveatchan-12-one;Napellonine;Zongorine;(3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-1-Ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one;Napellonin;Xuan-Wu 2;Songorine,BullatineG;ShiMoburo base I |
| CAS號(hào) | 509-24-0 |
| 分子式 | C22H31NO3 |
| 分子量 | 357.49 |
| EINECS號(hào) | 200-158-5 |
| 相關(guān)類(lèi)別 | 標(biāo)準(zhǔn)品;中藥對(duì)照品;對(duì)照品;植物提取物;標(biāo)準(zhǔn)品-對(duì)照品;生物堿;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品，對(duì)照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol文件 | 509-24-0.mol |
| 結(jié)構(gòu)式 |  |
準(zhǔn)葛爾烏頭堿 性質(zhì)
| 熔點(diǎn) | 201-203℃ |
|---|---|
| 比旋光度 | D20 -135.4° |
| 沸點(diǎn) | 535.8±50.0 °C(Predicted) |
| 密度 | 1.29 |
| 溶解度 | DMF：10mg/mL； DMF:PBS (pH 7.2) (1:4)：0.20 mg/ml； DMSO：5mg/mL；乙醇：微溶 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 14.20±0.60(Predicted) |
| 顏色 | 白色至米白色 |
Songorine 是從烏頭屬中分離出的一種二萜生物堿。Songorine 是大鼠腦中的 GABAA 受體拮抗劑，具有抗癌，抗心律不齊和抗炎活性。Songorine 有潛力用于上皮性卵巢癌 (EOC) 的研究。
藥理藥效:1.對(duì)中樞神經(jīng)系統(tǒng)的作用:宋果靈400mg/kg皮下注射,可降低小鼠自發(fā)活動(dòng),對(duì)兔有微弱的鎮(zhèn)靜作用。能延長(zhǎng)小鼠用催眠藥引起的麻醉時(shí)間,對(duì)兔有降溫作用。高劑量時(shí)抑制、低劑量時(shí)刺激中樞神經(jīng),產(chǎn)生興奮作用；2.其他作用:準(zhǔn)噶爾烏頭堿大劑量可阻斷神經(jīng)節(jié)顯示降壓作用,小劑量則翻轉(zhuǎn)利血平的降壓作用。具有抗乙酰膽堿和加強(qiáng)腎上腺素的作用。3.毒性:小鼠LD50 (mg/kg):灌胃1575,皮下注射630,腹腔注射485,靜脈注射142.5。對(duì)大鼠長(zhǎng)期給50mg/kg劑量,其心、肝、腎、腦等均出現(xiàn)毒性變化。
IC50: GABAA receptor
Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorine?inhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax. Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD 50 and ED 50 values of 142 mg and 7.3mg, respectively.
化學(xué)性質(zhì)
白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于川烏，烏頭。用途
一枝蒿庚素具有降壓，鎮(zhèn)痛的作用。用途
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等藥理藥效:1.對(duì)中樞神經(jīng)系統(tǒng)的作用:宋果靈400mg/kg皮下注射,可降低小鼠自發(fā)活動(dòng),對(duì)兔有微弱的鎮(zhèn)靜作用。能延長(zhǎng)小鼠用催眠藥引起的麻醉時(shí)間,對(duì)兔有降溫作用。高劑量時(shí)抑制、低劑量時(shí)刺激中樞神經(jīng),產(chǎn)生興奮作用；2.其他作用:準(zhǔn)噶爾烏頭堿大劑量可阻斷神經(jīng)節(jié)顯示降壓作用,小劑量則翻轉(zhuǎn)利血平的降壓作用。具有抗乙酰膽堿和加強(qiáng)腎上腺素的作用。3.毒性:小鼠LD50 (mg/kg):灌胃1575,皮下注射630,腹腔注射485,靜脈注射142.5。對(duì)大鼠長(zhǎng)期給50mg/kg劑量,其心、肝、腎、腦等均出現(xiàn)毒性變化。
安全信息
| 毒性 | LD50 in mice (mg/kg): 1575 orally, 630 s.c., 485 i.p., 142.5 i.v.; in rats (mg/kg): 407.5 i.p. (Bisset) |
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| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/05/22 | S9065 | 準(zhǔn)葛爾烏頭堿 Songorine | 509-24-0 | 1mg | 1204.89元 |