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Analytical Chemistry

Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure Chemical Name CAS MF
EPN EPN 2104-64-5 C14H14NO4PS
AFLATOXIN M1 AFLATOXIN M1 6795-23-9 C17H12O7
CARBOFURAN-3-HYDROXY CARBOFURAN-3-HYDROXY 16655-82-6 C12H15NO4
Fluorescein 6-isothiocyanate Fluorescein 6-isothiocyanate 18861-78-4 C21H11NO5S
ALDICARB-SULFONE ALDICARB-SULFONE 1646-88-4 C7H14N2O4S
AMBERLITE(R) IRA-900 AMBERLITE(R) IRA-900 9050-97-9 CH3BN-
METHYL 12-HYDROXYSTEARATE METHYL 12-HYDROXYSTEARATE 141-23-1 C19H38O3
D-ALPHA-METHYLBENZYL ISOTHIOCYANATE D-ALPHA-METHYLBENZYL ISOTHIOCYANATE 24277-44-9 C9H9NS
Pyributicarb Pyributicarb 88678-67-5 C18H22N2O2S
Dinitramine Dinitramine 29091-05-2 C11H13F3N4O4
N-DESMETHYLCLOZAPINE N-DESMETHYLCLOZAPINE 6104-71-8 C17H17ClN4
2-Mercaptoethanesulfonic acid 2-Mercaptoethanesulfonic acid 3375-50-6 C2H6O3S2
ARALDITE M ARALDITE M 3101-60-8 C13H18O2
Amylmetacresol Amylmetacresol 1300-94-3 C12H18O
17-OCTADECYNOIC ACID 17-OCTADECYNOIC ACID 34450-18-5 C18H32O2
PENTACHLOROANISOLE PENTACHLOROANISOLE 1825-21-4 C7H3Cl5O
Soybean Flour Soybean Flour 68513-95-1
Terbacil Terbacil 5902-51-2 C9H13ClN2O2
2,3,4,5-TETRACHLOROPHENOL 2,3,4,5-TETRACHLOROPHENOL 4901-51-3 C6H2Cl4O
BROMOPRIDE BROMOPRIDE 4093-35-0 C14H22BrN3O2
MEPENZOLATE BROMIDE MEPENZOLATE BROMIDE 76-90-4 C21H26BrNO3
3,4,5-TRICHLOROPHENOL 3,4,5-TRICHLOROPHENOL 609-19-8 C6H3Cl3O
6-METHYLCHRYSENE 6-METHYLCHRYSENE 1705-85-7 C19H14
Tris(2,3-dibromopropyl)phosphate Tris(2,3-dibromopropyl)phosphate 126-72-7 C9H15Br6O4P
Chlordecone Chlordecone 143-50-0 C10Cl10O
1-(PENTAFLUOROPROPIONYL)IMIDAZOLE 1-(PENTAFLUOROPROPIONYL)IMIDAZOLE 71735-32-5 C6H3F5N2O
METHYSTICIN METHYSTICIN 495-85-2 C15H14O5
QUINMERAC QUINMERAC 90717-03-6 C11H8ClNO2
4-CARBOXY-2,2,6,6-TETRAMETHYLPIPERIDINE 1-OXYL 4-CARBOXY-2,2,6,6-TETRAMETHYLPIPERIDINE 1-OXYL 37149-18-1 C10H18NO3*
1-Cyanocyclohexaneacetic acid 1-Cyanocyclohexaneacetic acid 133481-09-1 C9H13NO2
beta-D-Glucan beta-D-Glucan 9041-22-9 C18H30O14X2
ARACHIDONIC ACID ETHYL ESTER ARACHIDONIC ACID ETHYL ESTER 1808-26-0 C22H36O2
2,4,6-TRI-TERT-BUTYLNITROSOBENZENE 2,4,6-TRI-TERT-BUTYLNITROSOBENZENE 24973-59-9 C18H29NO
2,4-DIAMINO-6-DIMETHYLAMINO-1,3,5-TRIAZINE 2,4-DIAMINO-6-DIMETHYLAMINO-1,3,5-TRIAZINE 1985-46-2 C5H10N6
2,4,5-TRICHLOROTOLUENE 2,4,5-TRICHLOROTOLUENE 6639-30-1 C7H5Cl3
NEOERIOCITRIN NEOERIOCITRIN 13241-32-2 C27H32O15
Triflumizole Triflumizole 99387-89-0 C15H15ClF3N3O
NEBURON NEBURON 555-37-3 C12H16Cl2N2O
2,4-DB METHYL ESTER 2,4-DB METHYL ESTER 18625-12-2 C11H12Cl2O3
CAPTOPRIL DISULFIDE CAPTOPRIL DISULFIDE 64806-05-9 C18H28N2O6S2
1-PHENYLPENTADECANE 1-PHENYLPENTADECANE 2131-18-2 C21H36
DIMETHYL TETRADECANEDIOATE DIMETHYL TETRADECANEDIOATE 5024-21-5 C16H30O4
2-(Ethylamino)propiophenone hydrochloride 2-(Ethylamino)propiophenone hydrochloride 51553-17-4 C11H16ClNO
9-(BROMOMETHYL)ACRIDINE 9-(BROMOMETHYL)ACRIDINE 1556-34-9 C14H10BrN
IOXYNIL OCTANOATE IOXYNIL OCTANOATE 3861-47-0 C15H17I2NO2
2-BENZYL-1,2,3,6,7,11B-HEXAHYDRO-4H-PYRAZION[2,1-A] ISOQUINOLINE-4-ONE 2-BENZYL-1,2,3,6,7,11B-HEXAHYDRO-4H-PYRAZION[2,1-A] ISOQUINOLINE-4-ONE 54761-87-4 C19H18N2O2
TETRACONAZOLE TETRACONAZOLE 112281-77-3 C13H11Cl2F4N3O
2,4,4'-TRICHLOROBIPHENYL 2,4,4'-TRICHLOROBIPHENYL 7012-37-5 C12H7Cl3
2,3-DICHLOROBIPHENYL 2,3-DICHLOROBIPHENYL 16605-91-7 C12H8Cl2
METHYL STEARATE METHYL STEARATE 27234-05-5 C19H38O2
CHLORFENAC CHLORFENAC 85-34-7 C8H5Cl3O2
M-CYMENE M-CYMENE 535-77-3 C10H14
MICROCYSTIN-LR MICROCYSTIN-LR 101043-37-2 C49H74N10O12
FLONICAMID FLONICAMID 158062-67-0 C9H6F3N3O
PENTACHLOROTHIOANISOLE PENTACHLOROTHIOANISOLE 1825-19-0 C7H3Cl5S
OXELADIN CITRATE OXELADIN CITRATE 52432-72-1 C20H33NO3.C6H8O7
2,4,6-TRIS(HEPTAFLUOROPROPYL)-1,3,5-TRIAZINE 2,4,6-TRIS(HEPTAFLUOROPROPYL)-1,3,5-TRIAZINE 915-76-4 C12F21N3
2,3-DIHYDRO-6-ISOTHIOCYANATO-1,4-PHTHALAZINEDIONE 2,3-DIHYDRO-6-ISOTHIOCYANATO-1,4-PHTHALAZINEDIONE 107807-39-6 C9H5N3O2S
2,2',5-TRICHLOROBIPHENYL 2,2',5-TRICHLOROBIPHENYL 37680-65-2 C12H7Cl3
alpha-Amyrin alpha-Amyrin 638-95-9 C30H50O
Glycine, N-(2-aminobenzoyl)-, ethyl ester Glycine, N-(2-aminobenzoyl)-, ethyl ester 5973-34-2 C11H14N2O3
6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylic acid 6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylic acid 123040-79-9 C10H8ClNO4
3-Amino-3-azabicyclo[3.3.0]octane 3-Amino-3-azabicyclo[3.3.0]octane 54528-00-6 C7H14N2
(S)-Methyl 2-aminobutanoate (S)-Methyl 2-aminobutanoate 15399-22-1 C5H11NO2
(6S,8S,9S,10R,11S,13S,14S,17R)-17-(2,2-dihydroxyacetyl)-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (6S,8S,9S,10R,11S,13S,14S,17R)-17-(2,2-dihydroxyacetyl)-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
2-Diphenylmethylpiperidine hydrochloride 2-Diphenylmethylpiperidine hydrochloride 5807-81-8 C18H22ClN
(3aS-cis)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione (3aS-cis)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione 28092-52-6 C19H18N2O2S
L-Cefadroxil Impurity F(EP) L-Cefadroxil Impurity F(EP)
methyl L-prolinate methyl L-prolinate 2577-48-2 C6H11NO2
sodium (S,Z)-2-((1S,2R)-1-carboxylato-2-hydroxypropyl)-5-(4- hydroxybutylidene)-2,5-dihydrothiazole-4-carboxylate sodium (S,Z)-2-((1S,2R)-1-carboxylato-2-hydroxypropyl)-5-(4- hydroxybutylidene)-2,5-dihydrothiazole-4-carboxylate
3-(((3R)-3-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)-1,4-dioxan-2-ylamino)methyl)-1H-1,2,4-triazol-5(4H)-one 3-(((3R)-3-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)-1,4-dioxan-2-ylamino)methyl)-1H-1,2,4-triazol-5(4H)-one
2,4,6-tripropyl-1,3,5-trioxane 2,4,6-tripropyl-1,3,5-trioxane 2396-43-2 C12H24O3
Oseltamivir  Impurity 94 Oseltamivir Impurity 94
Oseltamivir  Impurity 82 Oseltamivir Impurity 82
Oseltamivir  Impurity 74 Oseltamivir Impurity 74
Uridine, 5'-(2-methylpropanoate) (9CI) Uridine, 5'-(2-methylpropanoate) (9CI) 886538-48-3 C13H18N2O7
Dapagliflozin Impurity 47 Dapagliflozin Impurity 47
Crisaborole Impurity 17 Crisaborole Impurity 17
Crisaborole Impurity 19 Crisaborole Impurity 19
1,5-Pentanedione, 1-(2-fluorophenyl)-5-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]- 1,5-Pentanedione, 1-(2-fluorophenyl)-5-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]- 2514695-40-8 C20H18FNO4
4-ethoxy-3-(4-pyridyl)-3-buten-2-one 4-ethoxy-3-(4-pyridyl)-3-buten-2-one 88349-61-5 C11H13NO2
1,3-dihydro-4-methyl-2H-1,5-benzodiazepin-2-one 1,3-dihydro-4-methyl-2H-1,5-benzodiazepin-2-one 6276-48-8 C10H10N2O
(E)-2-methoxy-4-(prop-1-enyl)phenol (E)-2-methoxy-4-(prop-1-enyl)phenol 5932-68-3 C10H12O2
Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)propoxy]methyl]- (9CI) Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)propoxy]methyl]- (9CI) 107021-20-5 C9H14N5O4P
Sitagliptin EP Impurity 7 Sitagliptin EP Impurity 7
Sitagliptin EP Impurity H Sitagliptin EP Impurity H
7-Benzofurancarboxamide, 4-amino-5-chloro-2,3-dihydro-3-hydroxy-N-[1-(3-methoxypropyl)-4-piperidinyl]- 7-Benzofurancarboxamide, 4-amino-5-chloro-2,3-dihydro-3-hydroxy-N-[1-(3-methoxypropyl)-4-piperidinyl]- 2636673-48-6 C18H26ClN3O4
Beprostatin impurity 4 Beprostatin impurity 4
cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole 65621-78-5 C17H16ClNO
methyl tosylcarbamate methyl tosylcarbamate 14437-03-7 C9H11NO4S
(1R,2R,4S,5S,7s,9r)-9-butyl-9-methyl-7-((2-phenylacryloyl)oxy)-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium (1R,2R,4S,5S,7s,9r)-9-butyl-9-methyl-7-((2-phenylacryloyl)oxy)-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium 786598-71-8 C21H28NO3+
(+)-2-Ethoxy-4-(N-3-Methyl-1(S)-(2-(1-Piperidinyl)Phenyl)-Butyl)Carbamoylmethyl) (+)-2-Ethoxy-4-(N-3-Methyl-1(S)-(2-(1-Piperidinyl)Phenyl)-Butyl)Carbamoylmethyl) 147770-06-7 C29H40N2O4
4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride 152402-97-6 C7H8Cl3N
4-(3-CYANO-2-METHYLPROPIONYL)ACETAMILIDE 4-(3-CYANO-2-METHYLPROPIONYL)ACETAMILIDE 42075-21-8
Erythromycin, 6-O-Methyl-2',4'-Bis-O-(Trimethylsilyl)-, 9-[O-(1-Methoxy-1-Methylethyl)Oxime] Erythromycin, 6-O-Methyl-2',4'-Bis-O-(Trimethylsilyl)-, 9-[O-(1-Methoxy-1-Methylethyl)Oxime] 119699-81-9 C48H94N2O14Si2
(R)-8-(3-aminopiperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-7-(3-oxobutyl)-3,7-dihydro-1H-purine-2,6-dione (R)-8-(3-aminopiperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-7-(3-oxobutyl)-3,7-dihydro-1H-purine-2,6-dione
Isavuconazole Impurity 37 Isavuconazole Impurity 37
"mixture of 2-amino-9-[[2-(hydroxymethoxy) ethoxy]methyl]-1,9-dihydro-6H-purin-6-one and 2-amino-9-[[2-(hydroxyethoxy)methoxy]methyl]-1,9- dihydro-6H-purin-6-one,"
N-((R)-1-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide N-((R)-1-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide 1375004-39-9 C29H39BN4O4
(S)-1-(2-(((1r,3R,5S,7S)-3,5-dihydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile (S)-1-(2-(((1r,3R,5S,7S)-3,5-dihydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile
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