WITHAFERIN A
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- $70 - $7875
- Product name: WITHAFERIN A
- CAS: 5119-48-2
- MF: C28H38O6
- MW: 470.6
- EINECS:999-999-2
- MDL Number:MFCD10687098
- Synonyms:WITHAFERIN A;5,6-beta-epoxy-4-beta,22,27-trihydroxy-1-5-beta-ergosta-24-dien-26-oicacid ;delta-lactone,(20s,22r)-oxo ;nsc-101088 ;(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone;NSC 273757;Withaferine;(20S,22R)-5,6β-Epoxy-4β,22,27-trihydroxy-1-oxo-5β-ergosta- 2,24-dien-26-oic Acid δ-Lactone
38 prices
Selected condition：
Brand
- Adipogen Life Sciences
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Frontier Specialty Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1
- 1mg
- 2mg
- 5MG
- 10MG
- 20mg
- 25mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0490-M001
- Product descriptionWithaferin A ≥98%(HPLC)
- Packaging1mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberSHG0007135
- Product descriptionWITHAFERIN A 95.00%
- Packaging10MG
- Price$583.8
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberSHG0007135
- Product descriptionWITHAFERIN A 95.00%
- Packaging1MG
- Price$650.27
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberSHG0007135
- Product descriptionWITHAFERIN A 95.00%
- Packaging5MG
- Price$902.3
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7199
- Product descriptionWithaferin A
- Packaging1mg
- Price$104
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7199
- Product descriptionWithaferin A
- Packaging5mg
- Price$395
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIW4202
- Product descriptionWithaferin A
- Packaging1mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIW4202
- Product descriptionWithaferin A
- Packaging5mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIW4202
- Product descriptionWithaferin A
- Packaging10mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN91895
- Product descriptionWithaferin A
- Packaging10mg
- Price$318
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number4490
- Product descriptionWithaferin A
- Packaging1mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number4490
- Product descriptionWithaferin A
- Packaging5mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number4490
- Product descriptionWithaferin A
- Packaging10mg
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number4490
- Product descriptionWithaferin A
- Packaging20mg
- Price$490
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545982
- Product descriptionWithaferin A >98%
- Packaging1mg
- Price$197.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545982
- Product descriptionWithaferin A >98%
- Packaging5mg
- Price$513.4
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0490-M001 | Withaferin A ≥98%(HPLC) | 1mg | $70 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0007135 | WITHAFERIN A 95.00% | 10MG | $583.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0007135 | WITHAFERIN A 95.00% | 1MG | $650.27 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0007135 | WITHAFERIN A 95.00% | 5MG | $902.3 | 2021-12-16 | Buy |
| ApexBio Technology | B7199 | Withaferin A | 1mg | $104 | 2021-12-16 | Buy |
| ApexBio Technology | B7199 | Withaferin A | 5mg | $395 | 2021-12-16 | Buy |
| Apolloscientific | BIW4202 | Withaferin A | 1mg | $70 | 2021-12-16 | Buy |
| Apolloscientific | BIW4202 | Withaferin A | 5mg | $195 | 2021-12-16 | Buy |
| Apolloscientific | BIW4202 | Withaferin A | 10mg | $320 | 2021-12-16 | Buy |
| Arctom | CFN91895 | Withaferin A | 10mg | $318 | 2021-12-16 | Buy |
| AvaChem | 4490 | Withaferin A | 1mg | $79 | 2021-12-16 | Buy |
| AvaChem | 4490 | Withaferin A | 5mg | $190 | 2021-12-16 | Buy |
| AvaChem | 4490 | Withaferin A | 10mg | $290 | 2021-12-16 | Buy |
| AvaChem | 4490 | Withaferin A | 20mg | $490 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545982 | Withaferin A >98% | 1mg | $197.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545982 | Withaferin A >98% | 5mg | $513.4 | 2021-12-16 | Buy |
Properties
Melting point :252-253℃
alpha :D28 +125° (c = 1.30 in CHCl3)
Boiling point :680.7±55.0 °C(Predicted)
Density :1.28
Flash point :226℃
storage temp. :Desiccate at -20°C
solubility :Soluble in DMSO (up to 20 mg/ml)
pka :13.49±0.70(Predicted)
form :White solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :DBRXOUCRJQVYJQ-CKNDUULBSA-N
alpha :D28 +125° (c = 1.30 in CHCl3)
Boiling point :680.7±55.0 °C(Predicted)
Density :1.28
Flash point :226℃
storage temp. :Desiccate at -20°C
solubility :Soluble in DMSO (up to 20 mg/ml)
pka :13.49±0.70(Predicted)
form :White solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :DBRXOUCRJQVYJQ-CKNDUULBSA-N
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Up-regulation of vimentin expression is one of the hallmarks of the epithelial-mesenchymal transition that accompanies the transformation of pre-metastatic to metastatic cancer cells. Withaferin A is a steroidal lactone present in W. somnifera that at 2-25 μM has been shown to bind to and induce aggregation of vimentin intermediate filaments in cultured endothelial cells and fibroblasts, causing apoptosis. As such, it has been proposed as an anti-tumor agent to target metastatic cells that up-regulate vimentin expression. At 2 mg/kg, withaferin A exhibits potent inhibition of angiogenesis in a mouse model of injury-induced corneal neovascularization. Withaferin A can also induce perinuclear aggregates in other intermediate filament networks including peripherin, neurofilament-triplet protein, and keratin as well as disrupt the organization of microtubules and actin/microfilaments.Related product price
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