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ChemicalBook >> CAS DataBase List >> SB 431542

SB 431542

SB 431542 price.
  • $32 - $2268
  • Product name: SB 431542
  • CAS: 301836-41-9
  • MF: C22H16N4O3
  • MW: 384.39
  • EINECS:
  • MDL Number:MFCD05865244
  • Synonyms:SB-431542/SB431542;SB 431542, >=98%;4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide SB431542;SB 431542 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide;4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate;SB 431542;4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE;4-[4-(3,4-METHYLENEDIOXYPHENYL)-5-(2-PYRIDYL)-1H-IMIDAZOL-2-YL]-BENZAMIDE
31 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • Labseeker
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
Package
  • 10
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product numberJ52510
  • Product descriptionSB 431542
  • Packaging5mg
  • Price$48
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0002538
  • Product descriptionSB-431542 HYDRATE 95.00%
  • Packaging5MG
  • Price$707.04
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8249
  • Product descriptionSB 431542
  • Packaging50mg
  • Price$329
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60029
  • Product descriptionSB 431542 ≥98%
  • Packaging10mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546061
  • Product descriptionSB 431542 >98%
  • Packaging5mg
  • Price$190.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546061
  • Product descriptionSB 431542 >98%
  • Packaging25mg
  • Price$423.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154737
  • Product descriptionSB 431542 >98%
  • Packaging100mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154737
  • Product descriptionSB 431542 >98%
  • Packaging250mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154737
  • Product descriptionSB 431542 >98%
  • Packaging1g
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB32804
  • Product descriptionSB 431542
  • Packaging50mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13031
  • Product descriptionSB 431542 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13031
  • Product descriptionSB 431542 ≥98%
  • Packaging5mg
  • Price$86
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13031
  • Product descriptionSB 431542 ≥98%
  • Packaging10mg
  • Price$122
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13031
  • Product descriptionSB 431542 ≥98%
  • Packaging25mg
  • Price$267
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0135
  • Product descriptionSB 431542 99.89%
  • Packaging10mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0135
  • Product descriptionSB 431542 99.89%
  • Packaging50mg
  • Price$360
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J52510 SB 431542 5mg $48 2021-12-16 Buy
American Custom Chemicals Corporation KIN0002538 SB-431542 HYDRATE 95.00% 5MG $707.04 2021-12-16 Buy
ApexBio Technology A8249 SB 431542 50mg $329 2021-12-16 Buy
Arctom CFN60029 SB 431542 ≥98% 10mg $198 2021-12-16 Buy
Biorbyt Ltd orb546061 SB 431542 >98% 5mg $190.4 2021-12-16 Buy
Biorbyt Ltd orb546061 SB 431542 >98% 25mg $423.3 2021-12-16 Buy
Biorbyt Ltd orb154737 SB 431542 >98% 100mg $510 2021-12-16 Buy
Biorbyt Ltd orb154737 SB 431542 >98% 250mg $765 2021-12-16 Buy
Biorbyt Ltd orb154737 SB 431542 >98% 1g $1504.5 2021-12-16 Buy
Biosynth Carbosynth FB32804 SB 431542 50mg $150 2021-12-16 Buy
Cayman Chemical 13031 SB 431542 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 13031 SB 431542 ≥98% 5mg $86 2024-03-01 Buy
Cayman Chemical 13031 SB 431542 ≥98% 10mg $122 2024-03-01 Buy
Cayman Chemical 13031 SB 431542 ≥98% 25mg $267 2024-03-01 Buy
ChemScene CS-0135 SB 431542 99.89% 10mg $96 2021-12-16 Buy
ChemScene CS-0135 SB 431542 99.89% 50mg $360 2021-12-16 Buy

Properties

Melting point :214 °C(dec.)
Boiling point :662.4±55.0 °C(Predicted)
Density :1.373
Flash point :354.4℃
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: 10 mg/mL, soluble
form :powder
pka :10.14±0.10(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :FHYUGAJXYORMHI-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer. Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.

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