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ChemicalBook >> CAS DataBase List >> Sb-742457

Sb-742457

Sb-742457 price.
  • $37 - $2683
  • Product name: Sb-742457
  • CAS: 607742-69-8
  • MF: C19H19N3O2S
  • MW: 353.44
  • EINECS:
  • MDL Number:MFCD12828872
  • Synonyms:Gsk 742457;Sb 742457;Sb-742457;3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline;SB 742457/GSK 742457;Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-;SB742457:Intepirdine;Intepirdine(SB742457)
19 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
Package
  • 1mg
  • 5MG
  • 10mg
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004714
  • Product descriptionGSK-742457 95.00%
  • Packaging5MG
  • Price$300.3
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004714
  • Product descriptionGSK-742457 95.00%
  • Packaging25MG
  • Price$1224.3
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2256
  • Product descriptionSB742457
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2256
  • Product descriptionSB742457
  • Packaging10mM(in 1mL DMSO)
  • Price$157
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2256
  • Product descriptionSB742457
  • Packaging25mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22200
  • Product descriptionSB-742457 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22200
  • Product descriptionSB-742457 ≥98%
  • Packaging5mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22200
  • Product descriptionSB-742457 ≥98%
  • Packaging10mg
  • Price$319
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22200
  • Product descriptionSB-742457 ≥98%
  • Packaging25mg
  • Price$704
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1087
  • Product descriptionIntepirdine 98.92%
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1087
  • Product descriptionIntepirdine 98.92%
  • Packaging10mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1087
  • Product descriptionIntepirdine 98.92%
  • Packaging25mg
  • Price$410
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1087
  • Product descriptionIntepirdine 98.92%
  • Packaging50mg
  • Price$690
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1087
  • Product descriptionIntepirdine 98.92%
  • Packaging100mg
  • Price$1100
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8354
  • Product descriptionIntepirdine(SB-742457,RVT-101） >98%
  • Packaging100mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8354
  • Product descriptionIntepirdine(SB-742457,RVT-101） >98%
  • Packaging250mg
  • Price$650
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation API0004714 GSK-742457 95.00% 5MG $300.3 2021-12-16 Buy
American Custom Chemicals Corporation API0004714 GSK-742457 95.00% 25MG $1224.3 2021-12-16 Buy
ApexBio Technology B2256 SB742457 5mg $105 2021-12-16 Buy
ApexBio Technology B2256 SB742457 10mM(in 1mL DMSO) $157 2021-12-16 Buy
ApexBio Technology B2256 SB742457 25mg $330 2021-12-16 Buy
Cayman Chemical 22200 SB-742457 ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 22200 SB-742457 ≥98% 5mg $169 2024-03-01 Buy
Cayman Chemical 22200 SB-742457 ≥98% 10mg $319 2024-03-01 Buy
Cayman Chemical 22200 SB-742457 ≥98% 25mg $704 2024-03-01 Buy
ChemScene CS-1087 Intepirdine 98.92% 5mg $110 2021-12-16 Buy
ChemScene CS-1087 Intepirdine 98.92% 10mg $190 2021-12-16 Buy
ChemScene CS-1087 Intepirdine 98.92% 25mg $410 2021-12-16 Buy
ChemScene CS-1087 Intepirdine 98.92% 50mg $690 2021-12-16 Buy
ChemScene CS-1087 Intepirdine 98.92% 100mg $1100 2021-12-16 Buy
DC Chemicals DC8354 Intepirdine(SB-742457,RVT-101） >98% 100mg $350 2021-12-16 Buy
DC Chemicals DC8354 Intepirdine(SB-742457,RVT-101） >98% 250mg $650 2021-12-16 Buy

Properties

Boiling point :608.3±45.0 °C(Predicted)
Density :1.292
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥17.65 mg/mL in DMSO; ≥2.13 mg/mL in EtOH with gentle warming and ultrasonic
pka :8?+-.0.10(Predicted)
form :solid
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM). SB-742457 (1 μM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an EC50 value of 21 nM in NG108-15 neuroblastoma cells. In vivo, SB-742457 (1.5 mg/kg, p.o.) reverses deficits in novel object recognition induced by scopolamine in rats. It also reverses age-induced impairments in spatial memory acquisition and retention in rats in the Morris water maze. SB-742457 (3.0 mg/kg, i.p.) reduces the number of licking bouts by 24% compared with control in rats trained to lick a glucose solution, indicating a role in satiety and obesity management.

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