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ChemicalBook >> CAS DataBase List >> RG108

RG108

RG108 price.
  • $42 - $2416
  • Product name: RG108
  • CAS: 48208-26-0
  • MF: C19H14N2O4
  • MW: 334.33
  • EINECS:
  • MDL Number:MFCD08705332
  • Synonyms:(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;RG108/RG-108;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;N-Phthaloyl-L-tryptophan;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-;N-Phthaloyl-L-tryptophan (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;DNA Methyltransferase Inhibitor;N-Phthalyl-L-tryptophan
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  • AK Scientific
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  • 100mg
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  • 10mM(in 1mL DMSO)
  • 200MG
  • 250mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product numberSYN3037
  • Product descriptionRG-108
  • Packaging10mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ64630
  • Product descriptionDNA Methyltransferase Inhibitor
  • Packaging10mg
  • Price$176
  • Updated2023-06-20
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging5mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging10mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging50mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging100mg
  • Price$111
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging250mg
  • Price$162
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging1g
  • Price$383
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging5g
  • Price$1335
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1913
  • Product descriptionRG108
  • Packaging25mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1913
  • Product descriptionRG108
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS592942
  • Product descriptionRG108 ≥98%
  • Packaging5mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS592942
  • Product descriptionRG108 ≥98%
  • Packaging10mg
  • Price$54
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS592942
  • Product descriptionRG108 ≥98%
  • Packaging50mg
  • Price$87
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS592942
  • Product descriptionRG108 ≥98%
  • Packaging100mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS592942
  • Product descriptionRG108 ≥98%
  • Packaging250mg
  • Price$160
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN3037 RG-108 10mg $130 2021-12-16 Buy
Alfa Aesar J64630 DNA Methyltransferase Inhibitor 10mg $176 2023-06-20 Buy
Ambeed A548158 RG108 98+% 5mg $42 2021-12-16 Buy
Ambeed A548158 RG108 98+% 10mg $55 2021-12-16 Buy
Ambeed A548158 RG108 98+% 50mg $88 2021-12-16 Buy
Ambeed A548158 RG108 98+% 100mg $111 2021-12-16 Buy
Ambeed A548158 RG108 98+% 250mg $162 2021-12-16 Buy
Ambeed A548158 RG108 98+% 1g $383 2021-12-16 Buy
Ambeed A548158 RG108 98+% 5g $1335 2021-12-16 Buy
ApexBio Technology A1913 RG108 25mg $100 2021-12-16 Buy
ApexBio Technology A1913 RG108 10mM(in 1mL DMSO) $60 2021-12-16 Buy
Arctom AS592942 RG108 ≥98% 5mg $42 2021-12-16 Buy
Arctom AS592942 RG108 ≥98% 10mg $54 2021-12-16 Buy
Arctom AS592942 RG108 ≥98% 50mg $87 2021-12-16 Buy
Arctom AS592942 RG108 ≥98% 100mg $110 2021-12-16 Buy
Arctom AS592942 RG108 ≥98% 250mg $160 2021-12-16 Buy

Properties

Melting point :192-194℃
Boiling point :606.0±50.0 °C(Predicted)
Density :1.502±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >10mg/mL
pka :3.62±0.10(Predicted)
form :powder
color :yellow
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference :48208-26-0

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.

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