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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Epigenetics>DNA Methyltransferase Inhibitors>RG108
RG108
  • RG108

RG108 NEW

Price $39 $63 $119
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: RG108 CAS No.: 48208-26-0
Purity: 99.78% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameRG108
DescriptionRG108 (N-Phthalyl-L-tryptophan) is a DNA methyltransferase inhibitor with an IC50 of 115 nM.
Cell ResearchFor the determination of cellular growth and viability, cells are stained with trypan blue and counted using a standard counting grid.(Only for Reference)
Kinase AssayIn vitro methylation assay: The substrate DNA for the in vitro methylation assay is a 798 bp fragment (?423/+375 relative to the initiation codon) from the promoter region of the human p16Ink4a gene. The methylation reaction contains 350 to 400 ng substrate DNA and 4 units of M.SssI methylase (0.5 μM) in a final volume of 50 μL. Inhibitors are added to final concentrations of 10, 100, 200, and 500 μM, respectively. Reactions are done at 37 °C for 2 hours. After completion, the reaction is inactivated at 65 °C for 15 minutes and the DNA is purified using PCR Purification kit. Three hundred nanograms of purified DNA is digested for 3 hours at 60 °C with 30 units of BstUI and analyzed on 2% Tris-borate EDTA agarose gels.
In vivoIn iPS cells derived from SM, RG108 significantly reduces DNA activity. In tumor cells, RG108 inhibits gene demethylation and reactivation without affecting the methylation of telomeric gene sequences.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : 33.4 mg/mL (100 mM)
DMSO : 40 mg/mL (119.64 mM)
Keywordsinhibit | DNA Methyltransferase | Inhibitor | DNMTs | DNA MTases | RG 108 | RG108 | RG-108
Inhibitors RelatedGSK-3484862 | Levetiracetam | Dihydro-5-azacytidine FA | 5-Azacytidine | Procainamide hydrochloride | SW155246 | Zebularine | γ-Oryzanol | TFMB-(S)-2-HG | 6-Thioguanine | 5-Methyl-2'-deoxycytidine | Hinokitiol
Related Compound LibrariesMethylation Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Epigenetics Compound Library | Chromatin Modification Compound Library | Inhibitor Library | NO PAINS Compound Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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