Azilsartan Medoxomil
|
- $40 - $2900
- Product name: Azilsartan Medoxomil
- CAS: 863031-21-4
- MF: C30H24N4O8
- MW: 568.53
- EINECS:1308068-626-2
- MDL Number:MFCD19443688
- Synonyms:1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-, (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester;Azilsaran medoxomil;(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-+oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate;1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzim;1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester;Azilsartan medoxomil;Azilsartan MedoxoMil(TAK 491);(5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl 2-ethoxy-1-([2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]Methyl)-1H-benziMidazole-7-carboxylate
27 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 10mM(in 1mL DMSO)
- 1G
- 2G
- 5G
- 10g
- 25g
- 50g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007696
- Product descriptionAZILSARTAN MEDOXOMIL 95.00%
- Packaging1G
- Price$1600
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007696
- Product descriptionAZILSARTAN MEDOXOMIL 95.00%
- Packaging2G
- Price$2900
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2218
- Product descriptionAzilsartanMedoxomil
- Packaging5mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2218
- Product descriptionAzilsartanMedoxomil
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2218
- Product descriptionAzilsartanMedoxomil
- Packaging10mM(in 1mL DMSO)
- Price$273
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2218
- Product descriptionAzilsartanMedoxomil
- Packaging100mg
- Price$680
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2218
- Product descriptionAzilsartanMedoxomil
- Packaging250mg
- Price$1280
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD15814
- Product description1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
- Packaging2g
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD15814
- Product description1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
- Packaging5G
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD15814
- Product description1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
- Packaging10g
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD15814
- Product description1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
- Packaging25g
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD15814
- Product description1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
- Packaging50g
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23805
- Product descriptionAzilsartan Medoxomil ≥98%
- Packaging25mg
- Price$692
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23805
- Product descriptionAzilsartan Medoxomil ≥98%
- Packaging10mg
- Price$321
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23805
- Product descriptionAzilsartan Medoxomil ≥98%
- Packaging5mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23805
- Product descriptionAzilsartan Medoxomil ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0007696 | AZILSARTAN MEDOXOMIL 95.00% | 1G | $1600 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007696 | AZILSARTAN MEDOXOMIL 95.00% | 2G | $2900 | 2021-12-16 | Buy |
| ApexBio Technology | B2218 | AzilsartanMedoxomil | 5mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | B2218 | AzilsartanMedoxomil | 10mg | $150 | 2021-12-16 | Buy |
| ApexBio Technology | B2218 | AzilsartanMedoxomil | 10mM(in 1mL DMSO) | $273 | 2021-12-16 | Buy |
| ApexBio Technology | B2218 | AzilsartanMedoxomil | 100mg | $680 | 2021-12-16 | Buy |
| ApexBio Technology | B2218 | AzilsartanMedoxomil | 250mg | $1280 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD15814 | 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester | 2g | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD15814 | 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester | 5G | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD15814 | 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester | 10g | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD15814 | 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester | 25g | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD15814 | 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester | 50g | $400 | 2021-12-16 | Buy |
| Cayman Chemical | 23805 | Azilsartan Medoxomil ≥98% | 25mg | $692 | 2024-03-01 | Buy |
| Cayman Chemical | 23805 | Azilsartan Medoxomil ≥98% | 10mg | $321 | 2024-03-01 | Buy |
| Cayman Chemical | 23805 | Azilsartan Medoxomil ≥98% | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 23805 | Azilsartan Medoxomil ≥98% | 1mg | $44 | 2024-03-01 | Buy |
Properties
Melting point :160-161oC
Density :1.45
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka :6.99±0.20(Predicted)
form :Solid
color :White to Light Beige
Density :1.45
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka :6.99±0.20(Predicted)
form :Solid
color :White to Light Beige
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Azilsartan medoxomil (Edarbi), an angiotensin II receptor antagonist, was approved by the U.S. FDA in February 2011 for the treatment of hypertension in adults. The discovery of azilsartan was the result of a medicinal chemistry effort to identify an ARB with a different carboxylic acid isostere than the ones found in the marketed ARBs. Several of the marketed ARBs use a tetrazole group as a carboxylic acid isostere. The medicinal chemistry approach that led to azilsartan involved the replacement of this commonly used tetrazole with a 5-oxo-1,2,4-oxadiazole group. Azilsartan can be synthesized by Suzuki coupling of p-tolyl boronic acid to 2-bromobenzonitrile, followed by bromination of the methyl group. The bromide is displaced to introduce a protected 2-ethoxy-1H-benzo[d] imidazole-7-carboxylate. The cyano group is converted to a hydroxylamidine, followed by reaction with an alkyl-chloroformate and intramolecular cyclization to form the 5-oxo-1,2,4-oxadiazole ring. The acid is then deprotected and converted to a prodrug. The parent, azilsartan has been extensively characterized in vitro and compared with other marketed AT1 antagonists olmesartan, valsartan, telmisartan, irbesartan, and candesartan. Azilsartan was found to be a potent (IC50=2.6 nM), selective, inverse agonist of the AT1 receptor. From washout experiments, azilsartan was found have slow dissociation from the receptor and thus is characterized as an insurmountable antagonist.More related product prices
TAK 599 methyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona Cetirizine hydrochloride Pitavastatin calcium Zafirlukast Azilsartan 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester Regorafenib Pemetrexed disodium AG 490
