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ChemicalBook >> CAS DataBase List >> Amiodarone hydrochloride

Amiodarone hydrochloride

Amiodarone hydrochloride price.
  • $10 - $1880
  • Product name: Amiodarone hydrochloride
  • CAS: 19774-82-4
  • MF: C25H29I2NO3.ClH
  • MW: 681.77
  • EINECS:243-293-2
  • MDL Number:MFCD00069204
  • Synonyms:2-BUTYL-3-BENZOFURANYL 4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL KETONE HYDROCHLORIDE;(2-BUTYL-3-BENZOFURANYL)-[4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODO-PHENYL]-METHANONE HYDROCHLORIDE;AMIODARONE-D4 HCL;AMIODARONE HYDROCHLORIDE;AMIODARONUM HYDROCHLORIDE;2-butyl-3-benzofuryl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride ;AMIODARONEHCL(2-BUTYL-3-BENZOFURANYL-4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYLKETONE);ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl, hydamiodaronum hydrochloride
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Brand
  • AHH
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • a0575000
  • 50mg
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  • 1mL
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  • 500g
  • 10mM(in 1mL DMSO)
  • ManufacturerAHH
  • Product numberAPI-1627
  • Product descriptionAmiodarone hydrochloride 98%
  • Packaging1g
  • Price$460
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ94468
  • Product descriptionAmiodaroneHCl
  • Packaging1g
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberF462
  • Product descriptionAmiodaroneHCl
  • Packaging5g
  • Price$43
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ60456
  • Product descriptionAmiodarone hydrochloride
  • Packaging1g
  • Price$14.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ60456
  • Product descriptionAmiodarone hydrochloride
  • Packaging5g
  • Price$35.65
  • Updated2024-03-01
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  • ManufacturerAlfa Aesar
  • Product numberJ60456
  • Product descriptionAmiodarone hydrochloride
  • Packaging25g
  • Price$134.65
  • Updated2024-03-01
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  • ManufacturerAmbeed
  • Product numberA143592
  • Product description(2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanonehydrochloride 97%
  • Packaging250mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA143592
  • Product description(2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanonehydrochloride 97%
  • Packaging1g
  • Price$24
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA143592
  • Product description(2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanonehydrochloride 97%
  • Packaging5g
  • Price$56
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA143592
  • Product description(2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanonehydrochloride 97%
  • Packaging25g
  • Price$190
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1389
  • Product descriptionAmiodaroneHCl
  • Packaging1g
  • Price$43
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1389
  • Product descriptionAmiodaroneHCl
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1389
  • Product descriptionAmiodaroneHCl
  • Packaging5g
  • Price$103
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberBA139263
  • Product descriptionAmiodarone hydrochloride
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFA17867
  • Product descriptionAmiodarone HCl
  • Packaging25g
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA17867
  • Product descriptionAmiodarone HCl
  • Packaging50g
  • Price$79.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1627 Amiodarone hydrochloride 98% 1g $460 2021-12-16 Buy
AK Scientific J94468 AmiodaroneHCl 1g $12 2021-12-16 Buy
AK Scientific F462 AmiodaroneHCl 5g $43 2021-12-16 Buy
Alfa Aesar J60456 Amiodarone hydrochloride 1g $14.65 2024-03-01 Buy
Alfa Aesar J60456 Amiodarone hydrochloride 5g $35.65 2024-03-01 Buy
Alfa Aesar J60456 Amiodarone hydrochloride 25g $134.65 2024-03-01 Buy
Ambeed A143592 (2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanonehydrochloride 97% 250mg $10 2021-12-16 Buy
Ambeed A143592 (2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanonehydrochloride 97% 1g $24 2021-12-16 Buy
Ambeed A143592 (2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanonehydrochloride 97% 5g $56 2021-12-16 Buy
Ambeed A143592 (2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanonehydrochloride 97% 25g $190 2021-12-16 Buy
ApexBio Technology B1389 AmiodaroneHCl 1g $43 2021-12-16 Buy
ApexBio Technology B1389 AmiodaroneHCl 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology B1389 AmiodaroneHCl 5g $103 2021-12-16 Buy
Biosynth Carbosynth BA139263 Amiodarone hydrochloride 100mg $50 2021-12-16 Buy
Biosynth Carbosynth FA17867 Amiodarone HCl 25g $50 2021-12-16 Buy
Biosynth Carbosynth FA17867 Amiodarone HCl 50g $79.5 2021-12-16 Buy

Properties

Melting point :154-158°C
Flash point :9℃
storage temp. :2-8°C
solubility :Soluble in chloroform, methanol.
pka :pKa (25°C) 6.56 ±0.06
form :Solid
color :White
λmax :242nm(MeOH)(lit.)
Merck :14,482
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
CAS DataBase Reference :19774-82-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6, 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

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