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ChemicalBook >> CAS DataBase List >> N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide

N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide

N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide price.
  • $32 - $2200
  • Product name: N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
  • CAS: 717906-29-1
  • MF: C22H21F3N6O3S
  • MW: 506.5
  • EINECS:
  • MDL Number:MFCD16038300
  • Synonyms:N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide;N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide;N-methyl-N-(2-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)phenyl)methanesulfonamide;N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF-431396;N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide hydrate;PF-431396 hydrate;PF 431396, >=98%;PF-431396;PF431396
18 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5mg
  • 2x5mg
  • 10MG
  • 25mg
  • 50mg
  • 100MG
  • 200mg
  • 250mg
  • 1g
  • 5g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product number2568AH
  • Product descriptionN-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)Amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamidehydrate
  • Packaging5g
  • Price$1072
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2637AH
  • Product descriptionN-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide
  • Packaging250mg
  • Price$1204
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000642
  • Product descriptionPF431396 95.00%
  • Packaging10MG
  • Price$779.63
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000642
  • Product descriptionPF431396 95.00%
  • Packaging100MG
  • Price$2194.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8692
  • Product descriptionPF-431396
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8692
  • Product descriptionPF-431396
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8692
  • Product descriptionPF-431396
  • Packaging50mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8692
  • Product descriptionPF-431396
  • Packaging200mg
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2107
  • Product descriptionPF431396 99%
  • Packaging2x5mg
  • Price$143
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17665
  • Product descriptionPF-431396 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17665
  • Product descriptionPF-431396 ≥98%
  • Packaging5mg
  • Price$100
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17665
  • Product descriptionPF-431396 ≥98%
  • Packaging10mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17665
  • Product descriptionPF-431396 ≥98%
  • Packaging50mg
  • Price$456
  • Updated2024-03-01
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7941
  • Product descriptionPF-431396 >98%
  • Packaging1g
  • Price$2200
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number48133
  • Product descriptionPF431396
  • Packaging10mg
  • Price$675
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPZ0185
  • Product descriptionPF-431396 hydrate ≥98% (HPLC)
  • Packaging5mg
  • Price$77.4
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2568AH N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)Amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamidehydrate 5g $1072 2021-12-16 Buy
AK Scientific 2637AH N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide 250mg $1204 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000642 PF431396 95.00% 10MG $779.63 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000642 PF431396 95.00% 100MG $2194.5 2021-12-16 Buy
ApexBio Technology A8692 PF-431396 10mM(in 1mL DMSO) $60 2021-12-16 Buy
ApexBio Technology A8692 PF-431396 10mg $80 2021-12-16 Buy
ApexBio Technology A8692 PF-431396 50mg $280 2021-12-16 Buy
ApexBio Technology A8692 PF-431396 200mg $700 2021-12-16 Buy
Axon Medchem Axon2107 PF431396 99% 2x5mg $143 2021-12-16 Buy
Cayman Chemical 17665 PF-431396 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 17665 PF-431396 ≥98% 5mg $100 2024-03-01 Buy
Cayman Chemical 17665 PF-431396 ≥98% 10mg $139 2024-03-01 Buy
Cayman Chemical 17665 PF-431396 ≥98% 50mg $456 2024-03-01 Buy
DC Chemicals DC7941 PF-431396 >98% 1g $2200 2021-12-16 Buy
Medical Isotopes, Inc. 48133 PF431396 10mg $675 2021-12-16 Buy
Sigma-Aldrich PZ0185 PF-431396 hydrate ≥98% (HPLC) 5mg $77.4 2024-03-01 Buy

Properties

Density :1.506
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :13.66±0.20(Predicted)
color :off-white to blue-gray

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption. PF-431396 is a pyrimidine-based dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively). In ovariectomized rats, it has been shown to increase bone formation, promoting osteoblast recruitment and activity.

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