???????
|
|
??????? ??
- ???
- 25°C
- ?? ?
- bp0.1 138-142°; bp1.7 185-190°; bp20 193-205°
- ??
- 1.0683 (rough estimate)
- ???
- nD25 1.5759-1.5765
- ?? ?? (pKa)
- pKa 3.90±0.08(H2O t undefined I = 0.30 (NaCl)) (Uncertain);8.68±0.06(H2O t undefined I = 0.30 (NaCl)) (Uncertain)
- ???
- 587.3mg/L(30℃)
- ???
- ????. ?? ???? ???? ????.
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ?? ?? ??? | 91-81-6(Hazardous Substances Data) | ||
|---|---|---|---|
| ?? | LD50 oral in mouse: 152mg/kg |
| ????(GHS): |
   
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| ?? ?: | Danger | |||||||||||||||||||||||||||||||||||||||||||||||||
| ??·?? ??: |
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??? ??
White, bitter, crystalline powder. Solutions are acid to litmus.Soluble in water and alcohol; very slightly soluble in ether; practically insoluble in chloroform and benzene; 1% solution in water has a pH of 4.3.??
This drug lessens the allergic response of the organism caused by histamine. Tripelennamine is used for allergic symptoms, rhinitis, conjunctivitis, and for allergic and anaphylactic reactions. Synonyms of this drug are pelanin and pyribenzamine.?? ???
Tripelennamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.????
SYMPTOMS: Symptoms of exposure to Tripelennamine may include euphoria, aplastic anemia, excitement, hallucinations, ataxia, incoordination, athetosis, convulsions, postictal depression, dry mouth, fixed dilated pupils, flushing of the face, fever, central nervous system depression, drowsiness and coma.????
Flash point data for Tripelennamine are not available. Tripelennamine is probably combustible.Safety Profile
Poison by ingestion and intraperitoneal routes. Human mutation data reported. Has been implicated in aplastic anemia. Used as an antdustasnine. Addicts have added it to paregoric to make "blue velvet," whtch can cause euphoria by injection. When heated to decomposition it emits toxic fumes of NOx.?? ?? ??
When pyribenzamine is incubated with rat liver microsomes, it is metabolized via N-oxide formation and N-dealkylation which includes removal of the dimethylamino moiety, the thiophenylmethyl moiety of methaphenilene, and the benzyl moiety of pyribenzamine.??????? ?? ?? ? ???
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???( 20)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 |
1087@dideu.com | China | 3292 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 7908 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 |
info@dycnchem.com | China | 52846 | 58 |
| TargetMol Chemicals Inc. | +17819995354 |
marketing@targetmol.com | United States | 19903 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12335 | 58 |
| Nanjing Xinmeihe Pharmaceutical Co., Ltd. | 025-57672321 13739186949 |
2548785915@qq.com | China | 307 | 58 |
| ShangHai Anpel Co, Ltd. | 18017382783 18017382783 |
shanpel@anpel.com.cn | China | 9611 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 029-81120477 17792793610 |
1033@dideu.com | China | 9786 | 58 |
| TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 24891 | 58 |
??????? ?? ??:
Chloropyramine hydrochloride
PYRILAMINE
Chloropyramine
Tripelennamine
PYRILAMINE MALEATE
Mirtazapine
TRIPELENNAMINE HYDROCHLORIDE
4-IODO-N-[2-[4-(METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-BENZAMIDE HYDROCHLORIDE
N'-(4-CYANOBUTYL)-N-(4-METHOXYBENZYL)-N'-METHYL-N-2-PYRIDINYL-1,2-ETHANEDIAMINE
N-(4-methoxybenzyl-N',N'-dimethyl-N-2-pyridylethylenediamine monohydrochloride
TRIPELENNAMINE CITRATE
TRIPELENNAMINE HYDROCHLORIDE,TRIPELENNAMINE HCL
4-FLUORO-N-(2-[4-(2-METHOXYPHENYL)1-PIPERAZINYL]ETHYL)-N-(2-PYRIDINYL)BENZAMIDE DIHYDROCHLORIDE
N-[(4-bromophenyl)methyl]-N'-ethyl-N'-methyl-N-2-pyridylethylenediamine maleate
MEPYRAMINE [PYRIDINYL 5-3H]-
PYRILAMINE TANNATE
2-{[3-(3-METHYLPYRIDIN-2-YL)-4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL]METHYL}-1H-ISOINDOLE-1,3(2H)-DIONE
2-{[3-(6-METHYLPYRIDIN-2-YL)-4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL]METHYL}-1H-ISOINDOLE-1,3(2H)-DIONE