??????
|
|
?????? ??
- ???
- 239-241 °C(lit.)
- ?? ?
- 392.36°C (rough estimate)
- ??
- 1.0697 (rough estimate)
- ???
- 1.4900 (estimate)
- ?? ??
- 2-8°C
- ???
- ?????(?? ???, ?????), ??????(?? ???), ???(?? ???)
- ??? ??
- Solid
- ?? ?? (pKa)
- 13.09±0.40(Predicted)
- ??
- ??? ???-???? ???? ??
- InChIKey
- WWYNJERNGUHSAO-XUDSTZEESA-N
- CAS ??????
- 6533-00-2(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 20/21/22-40 | ||
| ????? | 22-36 | ||
| WGK ?? | 3 | ||
| RTECS ?? | JF8259000 | ||
| HS ?? | 2937230000 | ||
| ?? ?? ??? | 6533-00-2(Hazardous Substances Data) | ||
| ?? | LD50 oral in rat: 5010mg/kg |
?????? C??? ??, ??, ??
??
Norgestrel is a synthetic progestin and a racemic mixture of dextronorgestrel and levonorgestrel , of which levonorgestrel is the biologically active component. In vivo, norgestrel administered via intrauterine device (IUD) prevents pregnancy in rats. Formulations containing nogestrel have been used as contraceptives.??? ??
White Solid??
A metabolite of Norgestrel.?? ??
Norgestrel, (17α)-(±)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one, and levonorgestrel, (17α)-(-)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one,have a C13 ethyl group instead of the C13 methyl but haveprogestational properties similar to those of norethindrone,with decreased androgenic effects. The ethyl group apparentlyprovides unfavorable steric interactions with the ARthat reduce the affinity compared with that with the PRs.Norgestrel is a racemic mixture, while levonorgestrel is thesingle active levorotatory enantiomer. Norgestrel is usedonly in oral contraceptives. Levonorgestrel is used in bothoral combination birth control products and polymeric implantsthat provide contraception for up to 5 years.Safety Profile
Human reproductive effects byingestion and implant: menstrual cycle changes ordisorders and female fertility index changes. Anexperimental teratogen. Experimental reproductiveeffects. Questionable carcinogen with experimentalneoplastigenic data. An o?????? ?? ?? ? ???
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???( 242)?? ??
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Ethyl 4-hydroxy-3-methoxycinnamate
Dehydroepiandrosterone
Venlafaxine hydrochloride
Oxaprozin
Etonogestrel
(-)-NORGESTREL 98%,(-)-NORGESTREL 98
13-ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one butyrate
Norgestrel-D5
norgestrel acetate