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N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) ??? ???
?? ??:
1477-57-2
???:
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
???(??):
SKL878;r-010-tk;win18441;win18446;win18,446;NSC 59354;bisdiamine;FERTILYSIN;bis-diamine;Fertilysine
CBNumber:
CB2146249
???:
C12H20Cl4N2O2
??? ??:
366.11
MOL ??:
1477-57-2.mol
MSDS ??:
SDS

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) ??

???
118-120 °C
?? ?
530℃
??
0.726
???
1.6200 (estimate)
???
275℃
?? ??
Inert atmosphere,2-8°C
???
???(?? ??), DMSO(?? ???), ???(?? ???, ??, ??? ??)
?? ?? (pKa)
12.28±0.46(Predicted)
??? ??
??
??? ??
??? ??
??
???? ?????
CAS ??????
1477-57-2
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 20/21/22-40
????? 24/25-45-36
?? LD50 orally in mice: >16000 mg/kg (Coulston)
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H351 ?? ??? ??? ??? (????? ?? ???? ???? ???? ??? ?? ????? ??? ???? ??) ??? ?? ?? 2 ?? P201, P202, P281, P308+P313, P405,P501
??????:
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
NFPA 704
1
2 0

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) C??? ??, ??, ??

??? ??

white crystalline powder

??

Win 18446 was shown to inhibit the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis and in the embryonic murine gonad.

??

ChEBI: A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neon tal and adult murine testis. It down-regulates sex related genes in zebrafish.

Safety Profile

Poison by intraperitoneal route.Human systemic effects by ingestion: nausea andvomiting. Human reproductive effects by ingestion:changes in spermatogenesis. An experimental teratogen.Other experimental reproductive effects. Human mutationdata reporte

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) ?? ?? ? ???

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N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) ?? ??

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