1477-57-2
中文名稱
N,N'-八亞甲基雙二氯乙酰胺
英文名稱
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
CAS
1477-57-2
分子式
C12H20Cl4N2O2
分子量
366.11
MOL 文件
1477-57-2.mol
更新日期
2023/06/12 20:30:50
1477-57-2 結(jié)構(gòu)式
基本信息
中文別名
佛替來辛N,N'-八亞甲基雙二氯乙酰胺
N,N′-八亞甲基雙(2,2-二氯乙酰胺)
N,N′-雙(二氯乙?；?-1,8-八亞甲基二胺
N,N'-1,8-辛二基雙[2,2-二氯]乙酰胺
英文別名
r-010-tkwin18441
win18446
win18,446
NSC 59354
bisdiamine
FERTILYSIN
bis-diamine
Fertilysine
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
所屬類別
化學試劑：酰胺物理化學性質(zhì)
熔點118-120 °C
熔點118-120 °C
沸點530℃
密度0.726
密度0.726
折射率1.6200 (estimate)
閃點275℃
儲存條件2-8°C
儲存條件Inert atmosphere,2-8°C
溶解度可溶于丙酮（非常少量）、DMSO（少量）、甲醇（少量、加熱、超聲處理)
酸度系數(shù)(pKa)12.28±0.46(Predicted)
形態(tài)固體
顏色白色至灰白色
CAS 數(shù)據(jù)庫1477-57-2
安全數(shù)據(jù)
警示詞警告
危險性描述H312+H332-H351
危險品標志Xn
危險類別碼20/21/22-40
安全說明24/25-45-36
毒性LD50 orally in mice: >16000 mg/kg (Coulston)
常見問題列表
生物活性
Win 18446 是具有口服活性的睪丸特異性的酶 ALDH1a2 的抑制劑，其 IC50 值為 0.3 μM。Win 18446 可逆的抑制多個物種的精子形成，抑制睪丸內(nèi)視黃醇 (HY-B1342) 合成視黃酸 (HY-14649)。體外研究
WIN 18446 (1 μM, 24 h) is able to suppress Stra8 expression in whole-testes cultures that contained both germ and somatic cells.
RT-PCR
| Cell Line: | Testes were collected from 2-dpp mice. |
| Concentration: | 1 μM. |
| Incubation Time: | 24 h. |
| Result: |
Results in a VAD-like phenotype in the testis.
Alone or in combination with ROL significantly reduced Stra8 expression. |
體內(nèi)研究
Win 18446 (200 mg/kg, Orally for 4, 8, and 16 weeks) significantly reduces intratesticular concentrations of retinoic acid, severely impaired spermatogenesis, and caused infertility.
| Animal Model: | Six-month-old male New Zealand white rabbits. |
| Dosage: | 200 mg/kg. |
| Administration: | Orally for 4, 8, and 16 weeks. |
| Result: |
Resulted in marked suppression of testicular weight over time.
Dramatically suppressed spermatogenesis. Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility. |