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ChemicalBook >> CAS DataBase List >>Cyclizine

Cyclizine

CAS No.
82-92-8
Chemical Name:
Cyclizine
Synonyms
Valoid;Emoquil;bw47-83;Marzine;Bw 47-83;Marazine;Marezine;Wellcome;Ciclizina;Nautazine
CBNumber:
CB5336795
Molecular Formula:
C18H22N2
Molecular Weight:
266.38
MDL Number:
MFCD00067334
MOL File:
82-92-8.mol
Last updated:2024-07-02 08:55:11

Cyclizine Properties

Melting point 105.5-107.5°
Boiling point 399.58°C (rough estimate)
Density 0.9934 (rough estimate)
refractive index 1.5840 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Slightly soluble in water and in ethanol (96 per cent).
form Solid
color White to off-white
EWG's Food Scores 1
FDA UNII QRW9FCR9P2

SAFETY

Risk and Safety Statements

Cyclizine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S361267 1-(DIPHENYLMETHYL)-4-METHYLPIPERAZINE AldrichCPR 82-92-8 250MG $179 2024-03-01 Buy
Matrix Scientific 058068 1-Benzhydryl-4-methylpiperazine 95% 82-92-8 25g $140 2021-12-16 Buy
Biosynth Carbosynth FC31349 Cyclizine Base 82-92-8 100g $140 2021-12-16 Buy
Biosynth Carbosynth FC31349 Cyclizine Base 82-92-8 50g $87.5 2021-12-16 Buy
Biosynth Carbosynth FC31349 Cyclizine Base 82-92-8 250g $275 2021-12-16 Buy
Product number Packaging Price Buy
S361267 250MG $179 Buy
058068 25g $140 Buy
FC31349 100g $140 Buy
FC31349 50g $87.5 Buy
FC31349 250g $275 Buy

Cyclizine Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.

Originator

Marezine,BurroughsWellcome,US,1953

Uses

Cyclizine is an antihistamine with a sedative effect used in the treatment of nausea and vomiting associated with motion sickness.

Uses

Cyclizine exhibits antihistamine and anticholinergic action and is used for vomiting and diarrhea. The exact mechanism of action is not known. Synonyms of this drug are marezine and migril.

Uses

H1 antihistamine

Preparation

Cyclizine is prepared through the alkylation of N-methylpiperazine with benzhydryl chloride.

Definition

ChEBI: An N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group.

Manufacturing Process

One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g) of N-methylpiperazine and about 10 cc of benzene and the whole was heated on the steam bath four hours. The contents of the flask was partitioned between ether and water, and the ethereal layer was washed with water until the washings were neutral. The base was then extracted from the ethereal layer by N hydrochloric acid and the extract, made acid to Congo red paper, was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by recrystallization from 95% alcohol melting above 250°C with decomposition. The addition of alkali to an aqueous solution of the dihydrochloride liberated the base which was recovered by recrystallization from petroleum ether melting at 105.5° to 107.5°C.

brand name

Marezine (GlaxoSmithKline).

Therapeutic Function

Antinauseant

General Description

Cyclizine hydrochloride,1-(diphenylmethyl)-4-methylpiperazine monohydrochloride(Marezine), occurs as a light-sensitive, white crystallinepowder with a bitter taste. It is slightly soluble in water(1:115), in alcohol (1:115), and in chloroform (1:75). It isused primarily in the prophylaxis and treatment of motionsickness. The lactate salt (Cyclizine Lactate Injection,United States Pharmacopoeia [USP]) is used for intramuscular(IM) injection because of the limited water solubilityof the hydrochloride. The injection should be stored in acold place, because if it is stored at room temperature forseveral months, a slight yellow tint may develop. This doesnot indicate a loss in biologic potency.

Clinical Use

It can be used not only in the treatment of allergic diseases, but also in the management of postoperative, irradiation or druginduced vomiting. Cyclizine dependence has been suggested to occur when it is used in combination with analgesics in long-term therapy. For this reason, several countries have removed cyclicine from analgesic combination preparations.

Synthesis

Cyclizine, 1-(diphenylmethyl)-4-methylpiperazine (16.1.15), is synthesized by alkylating 1-methylpiperazine with benzhydrylbromide.

Synthesis_82-92-8

Cyclizine Preparation Products And Raw materials

Raw materials

Preparation Products

Cyclizine Suppliers

Global( 74)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30231 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22793 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15350 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Hebei Fengjia New Material Co., Ltd 		+86-0311-87836622 +86-18712993135 sales01@tairunfaz.com China 8051 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 		027-88013699 17354350817 Ryan@jiutian-bio.com China 6000 58

View Lastest Price from Cyclizine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cyclizine USP/EP/BP pictures 2021-06-18 Cyclizine USP/EP/BP
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
(n-benzhydryl)(n’-methyl)diethylenediamine (N-Benzhydryl)(N'-methyl)diethylenediamine 1-(diphenylmethyl)-4-methyl-piperazin 1-Benzhydryl-4-methylpiperazine 1-Diphenylmethyl-4-methylpiperazine Bw 47-83 bw47-83 Ciclizina Compound 47-83 compound47-83 Emoquil Marazine Marezine Marzine Nautazine n-benzhydryl-n’-methylpiperazine N-Benzhydryl-N-methyl piperazine N-Benzhydryl-N'-methylpiperazine 1-DIPHENYLMETHYL-4-METHYL-PIPERAZINE HYDROCHLORIDE n-benzhydryl-n-methylpiperazine Ne-devomit Neo-devomit n-methyl-n’-benzhydrylpiperazine n-methyl-n’-benzyhydrylpiperazine N-Methyl-N'-benzhydrylpiperazine N-Methyl-N'-benzyhydrylpiperazine Piperazine, 1-(diphenylmethyl)-4-methyl- Valoid Wellcome Wellcome preparation 47-83 Wellcome prepn. 47-83 wellcomepreparation47-83 N-BENZHYDRYL-N'-METHYLPIPERAZINE HYDROCHLORIDE CYCLIZINE HCL Cyclizine (base and/or unspecified salts) CYCLYZINE Cyclizine Base Cyclizine USP/EP/BP cyclizineis1-benzhydryl-4-methylpiperazine.itcontainsnotlessthan98.5%andnotmorethan101.0%ofc18h22N2,calculatedwithreferencetothedriedsubstance Cyclizine Secreizine in methanol 82-92-8 305-25-3 Miscellaneous