7-Ethoxycoumarin
- CAS No.
- 31005-02-4
- Chemical Name:
- 7-Ethoxycoumarin
- Synonyms
- ETHOXYCOUMARIN;7-ETHOXYCOUMARIN;ETHOXYCOUMARIN, 7-;Ethylumbelliferone;Coumarin, 7-ethoxy-;7-Ethoxycoumarin>7-Ethoxycoumarin ,99%;7-ethoxychromen-2-one;ETHOXYCOUMARIN, 7-(RG);7-O-Ethylumbelliferone
- CBNumber:
- CB4357665
- Molecular Formula:
- C11H10O3
- Molecular Weight:
- 190.2
- MDL Number:
- MFCD00006877
- MOL File:
- 31005-02-4.mol
- MSDS File:
- SDS
| Melting point | 88-90 °C (lit.) |
|---|---|
| Boiling point | 265.69°C (rough estimate) |
| Density | 1.1803 (rough estimate) |
| refractive index | 1.4260 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Pale Brown |
| Water Solubility | Soluble in hot methanol (very faint turbidity), 95% ethanol (50 mg/ml), DMF, and DMSO. Insoluble in water. |
| BRN | 146200 |
| LogP | 2.310 (est) |
| CAS DataBase Reference | 31005-02-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | C8K66XCQ6L |
SAFETY
Risk and Safety Statements
| Precautionary statements | P261-P271-P280 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Hazard Codes | Xi | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
7-Ethoxycoumarin price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E1379 | 7-Ethoxycoumarin | 31005-02-4 | 25mg | $18.18 | 2024-03-01 | Buy |
| Sigma-Aldrich | E1379 | 7-Ethoxycoumarin | 31005-02-4 | 1g | $334 | 2024-03-01 | Buy |
| TCI Chemical | E0538 | 7-Ethoxycoumarin >97.0%(GC) | 31005-02-4 | 5g | $162 | 2024-03-01 | Buy |
| TCI Chemical | E0538 | 7-Ethoxycoumarin >97.0%(GC) | 31005-02-4 | 25g | $486 | 2024-03-01 | Buy |
| Alfa Aesar | L14116 | 7-Ethoxycoumarin, 99% | 31005-02-4 | 100mg | $42.65 | 2024-03-01 | Buy |
7-Ethoxycoumarin Chemical Properties,Uses,Production
Description
7-Ethoxycoumarin is oneof the general substrates for liver cytochrome P450 enzymes, and it is known that CYP1A1,1A2, and 2B1, drug inducedtypes (b-naphthoflavone, isosafrole, and phenobarbital,re-spectively, in rat liver) are mainly responsible for the ECDE activity in the liver.
Chemical Properties
BEIGE CRYSTALLINE POWDER
Uses
7-Ethoxycoumarin is commonly used for metabolism studies, including hepatocyte studies, liver perfusion techniques and cytochrome P450 studies.
7-Ethoxycoumarin has been used to study the functional activity of recombinant P450. ) It has also been used as an internal standard for in vitro S-warfarin 7-hydroxylation and high performance liquid chromatography (HPLC) analysis.
Uses
7-Ethoxycoumarin is a substrate for CYP2B6 used in fluorometric assays of microsomal monooxygenase activity.
Definition
ChEBI: 7-ethoxycoumarin is a member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group. It is an aromatic ether and a member of coumarins. It derives from an umbelliferone.
Biochem/physiol Actions
7-Ethoxycoumarin is a cytochrome P450 substrate.
Metabolism
7-Ethoxycoumarin is metabolized by many cytochrome P450 enzymes active in foreign compound metabolism and has been used as a prototypic substrate to monitor P450 (P450) activity in both hepatic and extrahepatic tissues.
The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families
7-Ethoxycoumarin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18151 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 11818 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
View Lastest Price from 7-Ethoxycoumarin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 7-Ethoxycoumarin
31005-02-4
|
US $30.00-64.00 / mg | 99.67% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-28 | 7-Ethoxycoumarin
31005-02-4
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-10-25 | 7-Ethoxycoumarin
31005-02-4
|
US $40.00-3.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- 7-Ethoxycoumarin
31005-02-4
- US $30.00-64.00 / mg
- 99.67%
- TargetMol Chemicals Inc.
-
- 7-Ethoxycoumarin
31005-02-4
- US $0.00-0.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- 7-Ethoxycoumarin
31005-02-4
- US $40.00-3.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
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