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Ethyl S-4-chloro-3-hydroxybutyrate

Ethyl S-4-chloro-3-hydroxybutyrate Struktur
86728-85-0
CAS-Nr.
86728-85-0
Englisch Name:
Ethyl S-4-chloro-3-hydroxybutyrate
Synonyma:
ETHYL (S)-4-CHLORO-3-HYDROXYBUTANOATE;ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE;ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE;SECHB;AST-4;PEFC-026;(S)-(?)-4-chL;(S)-Ethyl 4-chloro-3-;oro-3-hydroxybutyrate;4-chloro-3-hydroxyhexanoate
CBNumber:
CB9448087
Summenformel:
C6H11ClO3
Molgewicht:
166.6
MOL-Datei:
86728-85-0.mol

Ethyl S-4-chloro-3-hydroxybutyrate Eigenschaften

alpha 
-14.5 º (c=neat)
Siedepunkt:
93-95 °C5 mm Hg(lit.)
Dichte
1.19 g/mL at 25 °C(lit.)
Brechungsindex
n20/D 1.453(lit.)
Flammpunkt:
109 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
13.23±0.20(Predicted)
Aggregatzustand
Liquid
Farbe
Clear colorless to yellow
Optische Aktivit?t
[α]23/D 14°, neat
BRN 
4657170
InChI
InChI=1S/C6H11ClO3/c1-2-10-6(9)3-5(8)4-7/h5,8H,2-4H2,1H3/t5-/m0/s1
InChIKey
ZAJNMXDBJKCCAT-YFKPBYRVSA-N
SMILES
C(OCC)(=O)C[C@H](O)CCl
CAS Datenbank
86728-85-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,Xn
R-S?tze: 41-22
S-S?tze: 26-36-39
RIDADR  2810
WGK Germany  3
HazardClass  6.1
PackingGroup  III
HS Code  29181990
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Ethyl S-4-chloro-3-hydroxybutyrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R41:Gefahr ernster Augensch?den.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S39:Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

Colorless to light yellow liqui

Verwenden

Atorvastatin Intermediate

Biosynthese

Bioreductions catalyzed by alcohol dehydrogenases (ADHs) play an essential role in synthesizing chiral alcohols. A novel ADH, SmADH31, obtained from the Stenotrophomonas maltophilia genome, which can tolerate extremely high concentrations (6 M) of both substrate and product. The coexpression of SmADH31 and glucose dehydrogenase from Bacillus subtilis in Escherichia coli meant that as much as 660 g L–1 (4.0 M) ethyl 4-chloroacetoacetate was completely converted into ethyl (S)-4-chloro-3-hydroxybutyrate [(S)-CHBE] in a monophasic aqueous system with a >99.9% ee value and a high space-time yield (2664 g L–1 d–1). In the 100 ml-scale monophasic aqueous system (in triplicate), 66.0 g COBE (single batch charge) can be completely converted to (S)-CHBE (ee >99.9%) in only 6 h with 2 g of the SmADH31/GDH co-expressing cells. After extraction and evaporation, 61.6 g (S)-CHBE was isolated with 92% yield[1].

Allgemeine Beschreibung

Ethyl (S)-4-chloro-3-hydroxybutanoate is a chiral intermediate generally used to prepare atorvastatin, a cholesterol-lowering drug.

Ethyl S-4-chloro-3-hydroxybutyrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Ethyl S-4-chloro-3-hydroxybutyrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 451)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Jiangxi Sunway Chemical Co., Ltd.
+86-0794-5259909 +8615888611133
 dave@jxswchem.com China 22 58
Jiangxi Sunway Chemical Co., Ltd.
+86-0794-5259909 +8615888611133
 dave@jxswchem.com China 22 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325
 sales1@chuanghaibio.com China 5889 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410
 sales@ichemie.com China 1001 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 20284 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886
info@dakenam.com China 18751 58
Dalian Richfortune Chemicals Co., Ltd 		0411-84820922 8613904096939
 sales@richfortunechem.com China 304 57
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075
 jack.li@time-chemicals.com China 1803 55

86728-85-0()Verwandte Suche:

  • Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate 96%
  • Butanoic acid,4-chloro-3-hydroxy-, ethyl ester, (3S)-
  • (S) - (-) - chlorine - 4-3 - hydroxy ethyl butyrate
  • Ethyl (3S)-(-)-4-chloro-3-hydroxybutyrate
  • (S)-(-)-ETHYL-4-CHLORO 3-HYDROXYBUTANOATE
  • (S)-ETHYL 4-CHLORO-3-HYDROXYBUTYRATE
  • (S)-(-)-4-CHLORO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
  • (S)-4-CHLORO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
  • (S)-4-CHLORO-3-HYDROXY-N-BUTYRIC ACID ETHYL ESTER
  • Ehyl-4-(-)chloro-3-hydroxybutyrate
  • Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 96% (97% EE/GLC)
  • (2R,4R)-2,4-PENTANEDIOL EE 99+%
  • Ethyl(S)-(-)-4-chloro-3-Hydrox
  • ETHYL(S)-4-CHLORO-3-HYDROXY-BUTYRATE/ATS-4
  • ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE , EE 98%
  • methyl 3S-4-chloro-3-hydroxybutanoate
  • Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 98%, ee 98%
  • Ethyl (3S)-4-chloro-3-hydroxybutanoate
  • Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate,97%
  • (S)-(-)-ethyl-4-chloro 3-hydroxybutanoate(ATS-4)
  • Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 96%, ee 98%
  • Ethyl S-4-chloro-3-hydroxybutyate
  • 4-chloro-3-hydroxyhexanoate
  • ethyl()-4-chloro-3-hydroxybutanoate
  • Ethyl(S)-4-chloro-3-hydroxybutylate
  • S-4-Chloro-3-hydroxybutyrate
  • ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTANOATE
  • (-)-ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE
  • BUTANOIC ACID, 4-CHLORO-3-HYDROXY-, ETHYL ESTER, (S)
  • SECHB
  • Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 97% 1GR
  • )-4-chloro-3-hydroxybutyrate
  • (S)-Ethyl 4-chloro-3-
  • AST-4
  • Oxiracetam (S(-)-4-chloro-3-hydroxybutyric acid ethyl ester)
  • (S)-4-Chloro-3-Hydroxy-Butyric Acid Enthylester
  • PEFC-026
  • Ethyl (S)-4-Chloro-3-hydroxybutyrate >
  • (S)-(?)-4-chL
  • oro-3-hydroxybutyrate
  • (-)-ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE
  • ETHYL (S)-4-CHLORO-3-HYDROXYBUTANOATE
  • ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE
  • ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE
  • Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester, (3S)- (9CI, ACI)
  • 4-chloro-3-hydroxy-Butanoic acid ethyl ester (3S)- (9CI ACI)
  • (S)-4-Chloro-3-hydroxybutyric Acid Ethyl Ester(ATS-4)
  • (3S)-4-Chloro-3-hydroxy-butanoic acid ethyl ester
  • Ethyl-(S)-4 chloro-3-hydroxy-Butyrarte
  • Ethyl-S-(-)chloro-3-hydroxybutyrate
  • S (-) -4-chloro-3-hydroxybutyrate ethyl ester
  • 86728-85-0
  • 96728-85-0
  • C6H11ClO3
  • Organic Building Blocks
  • Esters
  • Asymmetric Synthesis
  • Chiral Building Blocks
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