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Cellulose acetate phthalate

Cellulose acetate phthalate Struktur
9004-38-0
CAS-Nr.
9004-38-0
Englisch Name:
Cellulose acetate phthalate
Synonyma:
cap-wako;CELLACEFATE;cellacetate;CELLACEFATE,NF;Fiber acetate ester;acetylphthalylcellulose;celluloseacetophthalate;celluloseacetylphthalate;ELLULOSE ACETATE PHTHALATE;CELLULOSE ACETATE PHTHALATE
CBNumber:
CB9396579
Summenformel:
C116H116O64
Molgewicht:
2534.12
MOL-Datei:
Mol file

Cellulose acetate phthalate Eigenschaften

L?slichkeit
Practically insoluble in water, freely soluble in acetone, soluble in diethylene glycol, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides
EPA chemische Informationen
Cellulose, acetate hydrogen 1,2-benzenedicarboxylate (9004-38-0)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22-36/37/38
S-S?tze: 24/25-36-26
WGK Germany  3
RTECS-Nr. FJ5692000
HS Code  39129010
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H252 In gro?en Mengen selbsterhitzungsf?hig; kann in Brand geraten. Self-heating substances and mixtures Category 2 Warnung P235+P410, P280, P407, P413, P420
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P235+P410 Kühl halten. Vor Sonnenbestrahlung schützen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P321 Besondere Behandlung
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P362 Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.
P407 Luftspalt zwischen Stapeln/ Paletten lassen.
P413 Schüttgut in Mengen von mehr als .? kg/.? lbs bei Temperaturen nicht über .? °C/.? °F aufbewahren.
P420 Von anderen Materialien entfernt aufbewahren.

Cellulose acetate phthalate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

Cellulose acetate phthalate is a hygroscopic, white to off-white, freeflowing powder, granule, or flake. It is tasteless and odorless, or might have a slight odor of acetic acid.

Verwenden

Enteric coating in pharmaceutical products.

Vorbereitung Methode

Cellulose acetate phthalate is produced by reacting the partial acetate ester of cellulose with phthalic anhydride in the presence of a tertiary organic base such as pyridine, or a strong acid such as sulfuric acid.

Pharmazeutische Anwendungen

Cellulose acetate phthalate (CAP) is used as an enteric film coating material, or as a matrix binder for tablets and capsules. Such coatings resist prolonged contact with the strongly acidic gastric fluid, but dissolve in the mildly acidic or neutral intestinal environment.
Cellulose acetate phthalate is commonly applied to solid-dosage forms either by coating from organic or aqueous solvent systems, or by direct compression. Concentrations generally used are 0.5–9.0% of the core weight. The addition of plasticizers improves the water resistance of this coating material, and formulations using such plasticizers are more effective than when cellulose acetate phthalate is used alone.
Cellulose acetate phthalate is compatible with many plasticizers, including acetylated monoglyceride; butyl phthalybutyl glycolate; dibutyl tartrate; diethyl phthalate; dimethyl phthalate; ethyl phthalylethyl glycolate; glycerin; propylene glycol; triacetin; triacetin citrate; and tripropionin. It is also used in combination with other coating agents such as ethyl cellulose, in drug controlledrelease preparations.
Therapeutically, cellulose acetate phthalate has recently been reported to exhibit experimental microbicidal activity against sexually transmitted disease pathogens, such as the HIV-1 retrovirus.

Sicherheitsprofil

An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.

Sicherheit(Safety)

Cellulose acetate phthalate is widely used in oral pharmaceutical products and is generally regarded as a nontoxic material, free of adverse effects. Results of long-term feeding in rats and dogs have indicated a low oral toxicity. Rats survived daily feedings of up to 30% in the diet for up to 1 year without showing a depression in growth. Dogs fed 16 g daily in the diet for 1 year remained normal.

Lager

Slow hydrolysis of cellulose acetate phthalate will occur under prolonged adverse conditions such as high temperatures and high humidity, with a resultant increase in free acid content, viscosity, and odor of acetic acid. However, cellulose acetate phthalate is stable if stored in a well-closed container in a cool, dry place.

Inkompatibilit?ten

Cellulose acetate phthalate is incompatible with ferrous sulfate, ferric chloride, silver nitrate, sodium citrate, aluminum sulfate, calcium chloride, mercuric chloride, barium nitrate, basic lead acetate, and strong oxidizing agents such as strong alkalis and acids.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Cellulose acetate phthalate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cellulose acetate phthalate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 159)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Shengyang Water Conservancy Engineering Co., Ltd.
+8615373025980
clara@hbshengyang.com China 875 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 997 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30239 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58

9004-38-0()Verwandte Suche:


  • acetylphthalylcellulose
  • cap-wako
  • cellacetate
  • celluloseacetatemonophthalate
  • Cellulose acetate phthalate NF
  • ELLULOSE ACETATE PHTHALATE
  • Cellulose Acetate Phthalate (CAP)
  • Cellulose Acetate Phthalate API
  • celluloseacetophthalate
  • celluloseacetylphthalate
  • CELLACEFATE
  • Cellulose acetate hydrogen 1,2-benzenedicarboxylate
  • CELLULOSE ACETATE HYDROGEN PHTHALATE
  • CELLULOSE ACETATE PHTHALATE
  • Cellulose acetate hydrogen phthalate, acetyl content 17.0-22.0%
  • CELLACEFATE,NF
  • CELLULOSE ACETATE PHTHALATE extrapure
  • CelluloseAcetatePhthalate(Cellacefate)
  • Cellacefate (125 mg) (Cellulose Acetate Phthalate)
  • Cellulose acetate phthalate CRS
  • Cellacefate for Identification RS
  • Fiber acetate ester
  • Cellulose acetate phthalate European Pharmacopoeia (EP) Reference Standard
  • Cellacefate (Cellulose Acetate Phthalate) (1098355)
  • Cellulose acetate phthalate,95%
  • 9004-38-0
  • C8H6O4xC2H4O2xW99
  • C116H116O64
  • LPLC/TLC/Paper Chromatography
  • LPLC Separation Media
  • Cation
  • Cellulose
  • Analytical Chromatography Product Catalog
  • Cation
  • Cellulose
  • LPLC Separation Media
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