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Sorafenib

Sorafenib Struktur
284461-73-0
CAS-Nr.
284461-73-0
Englisch Name:
Sorafenib
Synonyma:
sorafenib;Nexavar;SORAFENIB-D3;BAY 43-9006;Sorafenib Free Base;4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide;N-[4-Chloro-3-(trifluoromethyl)phenyl]-({4-[2-(N-methyl-carbamoyl)(4-pyridyloxy)]phenyl}amino)-carboxamide;SL-API;Sorafini;Forafenib
CBNumber:
CB9252510
Summenformel:
C21H16ClF3N4O3
Molgewicht:
464.82
MOL-Datei:
284461-73-0.mol

Sorafenib Eigenschaften

Schmelzpunkt:
202-204°C
Siedepunkt:
523.3±50.0 °C(Predicted)
Dichte
1.454±0.06 g/cm3(Predicted)
Dampfdruck
0Pa at 25℃
storage temp. 
Sealed in dry,Store in freezer, under -20°C
L?slichkeit
Chloroform (Slightly), DMSO (Slightly)
pka
12.89±0.70(Predicted)
Aggregatzustand
White to off-white solid.
Farbe
White to Off-White
Wasserl?slichkeit
100μg/L at 20℃
LogP
3.3 at 25℃
CAS Datenbank
284461-73-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
R-S?tze: 68/20/21/22-37/38
S-S?tze: 36-37-39
HS Code  29350090
Giftige Stoffe Daten 284461-73-0(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Sorafenib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sorafenib is a small molecular inhibitor of several kinases involved in tumor angiogenesis and proliferation, including, but not limited to, Raf (IC50=12nM for Raf-1), VEGFR (IC50=90nM for VEGFR-2 and IC50=12nM for VEGFR-3), and platelet derived growth factor receptor (IC50=57nM for PDGFR-b). Specifically, sorafenib blocks tumor progression by inhibiting cellular proliferation that is dependent on activation of the MAPK pathway (Raf) and/or inhibiting tumor angiogenesis through VEGFR and/or PDGFR. While it may be effective in the treatment of a variety of tumors, the first approvable indication is for renal cell carcinoma. Overall, the drug appears to be well tolerated by the majority of patients at the 400 mg b.i.d. continuous dosing. As an inhibitor of multiple kinases vital for tumor progression, sorafenib may possess wide-spectrum antitumor properties and may emerge as an effective weapon against a variety of solid tumors.

Chemische Eigenschaften

Light Yellow Solid

Charakteristisch

Class: receptor tyrosine kinase
Treatment: RCC, HCC, thyroid cancer
Elimination half-life = 25–48 h
Protein binding = 99.7%

Verwenden

Sorafenib Tosylate (Bay 43-9006, Nexavar) is a small molecular inhibitor of VEGFR, PDGFR, c-Raf and B-Raf with IC50s of 18 nM, 10 nM, 3 nM and 15 nM, respectively.

Definition

 ChEBI: Sorafenib is a member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group. It has a role as an antineoplastic agent, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor, a tyrosine kinase inhibitor, an angiogenesis inhibitor, an anticoronaviral agent and a ferroptosis inducer. It is a pyridinecarboxamide, a member of monochlorobenzenes, an aromatic ether, a member of (trifluoromethyl)benzenes and a member of phenylureas.

Indications

Sorafenib (Nexavar(R), Bayer) was the first approved inhibitor targeting the vascular endothelial growth factor (VEGF) family kinases, which include VEGFR1, VEGR2, and VEGFR3. Sorafenib was originally approved for the treatment of renal cell carcinoma (RCC) in 2005, hepatocellular carcinoma in 2007, and locally recurrent or metastatic thyroid carcinoma refractory to radioactive iodine treatment in 2013. Six other approved inhibitors with VEGFRs as the main targets are sunitinib (Sutent(R), Pfizer) for RCC, soft tissue sarcoma, thyroid cancer,metastatic pancreatic tumors, gastrointestinal stromal tumor, and several other types of carcinomas; pazopanib (Votrient(R), GlaxoSmithKline) for RCC, soft tissue sarcoma, and thyroid cancer; axitinib (Inlyta(R), Pfizer) for RCC,thyroid cancer, and aplastic anemia, as well as T315I-mutant Bcr–Abl1-driven leukemia; regorafenib (Stivarga(R), Bayer) for gastrointestinal stromal tumors and colorectal cancer; nintedanib (Ofev(R), Boehringer Ingelheim) for the non-oncological indication of idiopathic pulmonary fibrosis; and lenvatinib (Lenvima(R), Eisai Inc.) for RCC and different types of thyroid cancers. Sunitinib, pazopanib, and lenvatinib bind to the “DFG-in”conformation of VEGFRs, while axitinib, regorafenib, and nintedanib bind to inactive VEGFRs adopting the “DFG-out”conformation.

Sorafenib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sorafenib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 595)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Baoji Guokang Healthchem co.,ltd
+8615604608665 15604608665
dominicguo@gk-bio.com CHINA 9414 58
Yangzhou Qinyuan Pharmatech Co.,ltd
+86-18752526868
jennysun@yzqyyykj.com China 81 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
HangZhou RunYan Pharma Technology Co.,LTD.
+8618882027439
sales2@runyanpharma.com China 302 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
sales@frappschem.com China 880 50

284461-73-0()Verwandte Suche:


  • Sorafenib Tosylate(TINIBS)
  • Sorafenib free base for research
  • Forafenib
  • Sorafenib free base(Bay43-9006)
  • nexavar,sorafenib
  • BAY43-9006; NEXAVAR
  • Sorafenib-d4
  • Sorafenib Tosylate for research
  • Sorafenib 4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
  • 4-[4-[[[[4-chloro-3-((trifluoromethyl))phenyl]amino]carbonyl]amino]phenoxy]-N-methylpyridin-2-carboxamide
  • SORAFENIB TOLSYLATE
  • RAF1 KINASE INHIBITOR II
  • N-(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)-((4-(2-(N-METHYL-CARBAMOYL)(4-PYRIDYLOXY))PHENYL)AMINO)CARBOXAMIDE
  • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methyl-pyridine-2-carboxamide
  • 2-PyridinecarboxaMide,4-[4-[[[[4-chloro-3-(trifluoroMethyl)phenyl]aMino]carbonyl]aMino]phenoxy]-N-Methyl-
  • 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
  • BAY-43-900
  • N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea
  • SORAFENIB(FORR&DONLY)
  • SORAFENIB MESYLATE
  • 2-PyridinecarboxaMide,4-[4-[[[[4-chloro-3-(trifluoroMethyl)phenyl]
  • Sorafenib (Nexavar, BAY43-9006)
  • Sorafenib tosylate-001
  • N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea Sorafenib base
  • Sorafenib(W.S)
  • Sorafenib(free bass)
  • Sorafenib (10mM in DMSO)
  • Sorafini
  • SorafenibQ: What is Sorafenib Q: What is the CAS Number of Sorafenib Q: What is the storage condition of Sorafenib Q: What are the applications of Sorafenib
  • Sorafenib Free Base
  • Nexavar
  • N-[4-Chloro-3-(trifluoromethyl)phenyl]-({4-[2-(N-methyl-carbamoyl)(4-pyridyloxy)]phenyl}amino)-carboxamide
  • 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
  • sorafenib
  • SORAFENIB-D3
  • BAY 43-9006
  • Acetamide,N-[8-(aminosulfonyl)phenyl]-
  • CAS:284461-73-0
  • SL-API
  • N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea Sorafenib base
  • 284461-73-0
  • 4750207-59-1
  • C21H16ClF3N4O3C7H8SO3
  • C21H16ClF3N4O3
  • Bay 43-9006
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