ANTI-TAP Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-NXF1 polyclonal antibody is used to tag nuclear RNA export factor 1 protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of nuclear RNA export factor 1 in polyA-RNA nuclear export.

Allgemeine Beschreibung

Nuclear RNA export factor 1 (NXF1, TAP) is a nuclear RNA exporter protein that contains a noncanonical RNP-type RNA binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. Nuclear RNA export factor 1 exports poly(A)+RNA from the nucleus into the cytoplasm.

Biochem/physiol Actions

NXF1 is one member of a family of nuclear RNA export factor. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. NXF1 shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. NXF1 overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.

ANTI-TAP Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ANTI-TAP Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Nanjing Sai Ruirui Biotechnology Co., Ltd.	--	sales@shrbio.com	CHINA	6871	58
Shanghai Beinuo Biotechnology Co., Ltd.	--	beinuobio@163.com	CHINA	6580	58
Suzhou Ruinuode Biotechnology Co., Ltd.	--	2090855807@qq.com	CHINA	6063	58
Shanghai Hao Biological Technology Co., Ltd.	--	market@xlswkj.com	CHINA	6793	58
Riedel-de Haen AG	--		United States	6773	87
BD Biosciences	--		United States	5013	82
Chemicon Internatinal, Inc.	--	custserv@chemicon.com	United States	4175	65
BIODESIGN International/OEM Concepts	--	info@biodesign.com	United States	2376	50
Rockland Immunochemicals Inc.	--	info@rockland-inc.com	United States	2043	76

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• ANTI-TAP
• ANTI-TRANSPORTER ASSOCIATED PROTEIN
• ANTI-TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING
• Anti-DKFZp667O0311
• Anti-MEX67
• Anti-Nuclear RNA export factor 1
• Anti-NXF1 antibody produced in rabbit
• Anti-VDP P115 antibody produced in goat
• Anti-Vesicle docking protein