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Dinoproston

Prostaglandin E2  Struktur
363-24-6
CAS-Nr.
363-24-6
Bezeichnung:
Dinoproston
Englisch Name:
Prostaglandin E2
Synonyma:
PROSTAGLANDIN;DINOPROSTONE;PGE2;dinoproston;Propess;Cervidil;Prepidil;Dinoprostol;Prostaglandin E2 (PGE2);l-pge2
CBNumber:
CB8461799
Summenformel:
C20H32O5
Molgewicht:
352.47
MOL-Datei:
363-24-6.mol

Dinoproston Eigenschaften

Schmelzpunkt:
66-68 °C
alpha 
-85.5 º (c=1, C2H5OH)
Siedepunkt:
406.07°C (rough estimate)
Dichte
1.0601 (rough estimate)
Brechungsindex
1.6120 (estimate)
storage temp. 
-20°C
L?slichkeit
ethanol: 1 mg/mL
Aggregatzustand
powder
pka
pKa 4.77± 0.09(H2O,t=25±0.1,I=0.1(NaCl)) (Uncertain)
Farbe
Clear yellow to amber
Wasserl?slichkeit
insoluble
Merck 
14,7877
BRN 
4709356
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey
XEYBRNLFEZDVAW-ARSRFYASSA-N
CAS Datenbank
363-24-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 60-22-61
S-S?tze: 53-22-26-36/37/39-45
WGK Germany  3
RTECS-Nr. UK8000000
8-10
HS Code  29375000
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Dinoproston Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.
R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

White to pale yellowish-cream powder. Melting point 64-66°C, specific rotation -61°(26°C, c=1, THF). Easily hydrolyzed at pH<4 or pH>8. Soluble in chloroform, ethyl acetate, methanol, absolute ethanol and other organic solvents, slightly soluble in water.

Verwenden

The most common and most biologically potent of mammalian prostaglandins. Isolated from sheep prostate. Oxytocic; abortifacient.

Definition

ChEBI: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostagland ns.

Weltgesundheitsorganisation (WHO)

Dinoprostone, prostaglandin E2, was introduced into medicine in 1971 and is primarily used for cervical ripening during the induction of labour. It is available in various formulations for oral, parenteral and vaginal administration. Tablets, ampoules and vaginal dosage forms (tablets, pessaries, gel) remain registered in many countries.

Allgemeine Beschreibung

PGE2 Dinoprostone (Prostin E2;Cervidil) is a naturally occurring prostaglandin that is administeredin a single dose of 10 mg by controlled-release(0.3 mg/hr) vaginal insert to induce cervical ripening. Use ofthis agent will potentiate the effects of oxytocin.

Biologische Aktivit?t

Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP 1 , EP 2 , EP 3 and EP 4 receptors (K d values range between ~ 1-10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.

Sicherheitsprofil

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human reproductive effects by intravenous, intraplacental, and intravaginal routes: changes in the uterus, cervix and vagina; termination of pregnancy; and changes in ferthty. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Dinoproston Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dinoproston Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 331)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
HangZhou RunYan Pharma Technology Co.,LTD.
+8618882027439
sales2@runyanpharma.com China 302 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
Shanghai finete Pharmaceutical Co., Ltd.
+86-18221039705
CHINA 139 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 419 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58

363-24-6(Dinoproston)Verwandte Suche:


  • 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoicaci
  • l-5-heptenoicaci
  • l-7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoicacid
  • l-pge2
  • l-prostaglandine2
  • prostin
  • prostine2
  • 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid
  • (5Z,11A,13E,15S)-11,15-DIHYDROXY-9-OXO-PROSTA-5,13-DIEN-1OIC ACID
  • [5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIEN-1-OIC ACID
  • [5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIENOIC ACID
  • PROSTAGLANDIN E2
  • PROSTAGLANDINS E2
  • (15s)-prostaglandine2
  • (5z,11-alpha,13e,15s)-11,15-dihydroxy-9-oxo-prosta-13-dien-1-oicacid
  • 11,15-dihydroxy-9-oxo-,(5z,11-alpha,13e,15s)-prosta-13-dien-1-oicacid
  • PROSTAGLANDIN E2 CELL CULTURE TESTED
  • PROSTAGLANDIN E2 GAMMA-IRRADIATED*CELL C ULTURE TEST
  • PROSTAGLANDIN,PGE2
  • 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID
  • 7-(3-HydroxyProsta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
  • [5Z,11R,13E,15S,(-)]-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
  • Prostaglandin E2,98%
  • [5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROS
  • Prostaglandin E2,(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid, PGE2
  • Dinoprostone (50 mg) (COLD SHIPMENT REQUIRED)
  • cGMP Dinoprostone
  • Prostaglandin E2 Lipid Maps MS Standard
  • (5Z,11α,13E,15S)-
  • CervidilProstaglandin E2
  • (5z,11α,13e,15s)-11,15-dihydroxy-9-oxoprosta-5,13-dienoic acid
  • (E)-7-[(1S,2S,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid
  • 11α,15α-Dihydroxy-9-ketoprosta-5,13-dienoic acid
  • 11α,15α-Dihydroxy-9-oxo-5-cis,13-trans-prostadienoic acid
  • 5-Heptenoic acid, 7-[3a-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- (7CI)
  • Cerviprost
  • Enzaprost E
  • Minprositin E2
  • Minprostin E2
  • NSC 165560
  • NSC 196514
  • Prostarmon E
  • Prostenon
  • Prostenone
  • Prostin (prostaglandin)
  • U 12062
  • PGE2, (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
  • Dinoprostone, PGE2, (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
  • (5Z,11α,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
  • Dinoprostone PGE2
  • (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid
  • Prosta-5,13-dien-1-oicacid, 11,15-dihydroxy-9-oxo-, (5Z,11a,13E,15S)-
  • Dinoprostone (125 mg) (COLD SHIPMENT REQUIRED)
  • Prostaglandin E2-biotinamide
  • prostaglandin,PG
  • PROSTAGLANDIN E2, >=93% (HPLC), SYNT
  • Prostaglandin E2 MaxSpecStandard
  • Dinoprostone/Prostaglandin E2
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