Pyrimidine-5-carboxaldehyde
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- CAS-Nr.
- 10070-92-5
- Englisch Name:
- Pyrimidine-5-carboxaldehyde
- Synonyma:
- PYRIMIDINE-5-CARBALDEHYDE;5-PYRIMIDINECARBOXALDEHYDE;5-FORMYLPYRIMIDINE;RARECHEM AK ML 0565;PyriMidin-5-carbaldehyde;5-Pyrimidinecarbaldehyde;Pyrimidine-5-formaldehyde;PYRIMIDINE-5-CARBOXALDEHYDE;PYRIMIDINE-5-CARBOXYALDEHYDE;Pyrimidine-5-carboxylaldehyde
- CBNumber:
- CB8412180
- Summenformel:
- C5H4N2O
- Molgewicht:
- 108.1
- MOL-Datei:
- 10070-92-5.mol
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Pyrimidine-5-carboxaldehyde Eigenschaften
- Schmelzpunkt:
- 39-43°C
- Siedepunkt:
- 80-82°C 4mm
- Dichte
- 1.23
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 1.15±0.10(Predicted)
- Aggregatzustand
- solid
- Farbe
- Light yellow to yellow
- InChI
- InChI=1S/C5H4N2O/c8-3-5-1-6-4-7-2-5/h1-4H
- InChIKey
- FREJAOSUHFGDBW-UHFFFAOYSA-N
- SMILES
- C1=NC=C(C=O)C=N1
- CAS Datenbank
- 10070-92-5(CAS DataBase Reference)
Pyrimidine-5-carboxaldehyde Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Pyrimidine-5-carboxaldehyde is used in the preparation of (S)- and (R)-pyrimidyl alkanol by reacting with diisopropylzinc and (n-butyl)ethyl(n-hexyl)(n-propyl)methane.
Synthese
Under nitrogen, a solution of 5-bromopyrimidine (1 g, 6.3 mmol) in 60 mL anhydrous THF was added BuLi (2.5 M, 2.6 mL, 6.5 mmol) at -78° C. The resulting yellow solution was stirred for 20 min, after which ethyl formate (0.55 mL, 6.7 mmol) was added dropwise over 5 min. After 20 min, the reaction was quenched with 1.5 M THF/HCl solution (4.5 mL, 6.7 mmol). The cold bath was removed, and the reaction mixture was stirred for 1 h. THF was removed in vacco, 10 mL of water was then added. The mixture was extracted with CHCl3 (2*10 mL), and the combined organics were dried (MgSO4) and concentrated. The crude product was purified via flash column chromatography (5 per cent MeOH/CHCl3) to give 0.35 g (51 per cent) of the titled Pyrimidine-5-carboxaldehyde.
Pyrimidine-5-carboxaldehyde Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Pyrimidine-5-carboxaldehyde Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 292)Lieferanten
10070-92-5()Verwandte Suche:
- RARECHEM AK ML 0565
- PYRIMIDINE-5-CARBOXYALDEHYDE
- PYRIMIDINE-5-CARBOXALDEHYDE
- 5-Pyrimidinecarboxaldehyde (7CI,8CI,9CI)
- 5-Pyrimidinecarbaldehyde
- Pyrimidine-5-carboxylaldehyde
- PyriMidin-5-carbaldehyde
- 5-Formylpyrimidine, 5-Formyl-1,3-diazine
- PyriMidine-5-carbaldehyde 5-ForMylpyriMidine
- Pyrimidine-5-carboxaldehyde ISO 9001：2015 REACH
- 5-FORMYLPYRIMIDINE
- PYRIMIDINE-5-CARBALDEHYDE
- 5-PYRIMIDINECARBOXALDEHYDE
- Pyrimidine-5-formaldehyde
- 10070-92-5
- Heterocycle-Pyrimidine series
- Aromatics
- Heterocycles
- PYRIMIDINE
- Aldehyde
- Building Blocks
- Pyrimidines
- Boronic Acid
- Heterocyclic Compounds
