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Matrine

Matrine Struktur
519-02-8
CAS-Nr.
519-02-8
Englisch Name:
Matrine
Synonyma:
Vegard;MATRINE;MATRENE;Matrines;MATRINIUM;MATRINE(P);(+)-MATRINE;Matrine CRS;MASSMARK 1621;alpha-matrine
CBNumber:
CB8284723
Summenformel:
C15H24N2O
Molgewicht:
248.36
MOL-Datei:
519-02-8.mol

Matrine Eigenschaften

Schmelzpunkt:
77 C
Siedepunkt:
86-88C/2,5Torr
alpha 
D20 +38° (alc)
Dichte
1,191g/cm
Brechungsindex
1,536
storage temp. 
Sealed in dry,2-8°C
L?slichkeit
Soluble in Water (up to 25 mg/ml)
Aggregatzustand
solid
pka
9.47±0.20(Predicted)
Farbe
White
Optische Aktivit?t
+37.926 (c 1.69, H2O)
Merck 
14,5759
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
LogP
1.440 (est)
CAS Datenbank
519-02-8(CAS DataBase Reference)
NIST chemische Informationen
Matrine(519-02-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22-37/38-41-48-22
S-S?tze: 22-26-36/37/39-45-36/37
WGK Germany  3
RTECS-Nr. OQ1754000
HS Code  13021990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Matrine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augensch?den.
R48:Gefahr ernster Gesundheitssch?den bei l?ngerer Exposition.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens Aiton. The extraction process involves the use of organic solvents on dry roots, plants, and fruits of kushen 苦參 (Sophora flavescens Ait). Matrine is also present in S. alopecuroides L. and S. subprostrata Chun et T. Chen.
Chinese medicine Radix Sophora flavescentis have dampness eliminating insecticide and diuretic effects. Sophora flavescens is used for heat dysentery, hemafecia, jaundice and anuria, red leukorrhea, vulva pruritus, eczema, wet sores, skin itching, scabies, ringworm, and trichomonas vaginitis. Sophora flavescens is recorded in the ancient Materia Medica. “Southern Yunnan Materia Medica” also recorded the effects of Saphora flavescens.
Sophora flavescens is a species of Sophora japonica and is distributed in temperate and subtropical regions. Sophora flavescens is widely distributed in China, mainly in the north of Hebei, the west of Henan, and southwest of Shandong, Anhui, Hubei, and Guizhou.

Chemische Eigenschaften

Matrine is a white crystal or powder in the form of needles, which can turn yellow with prolonged exposure to air. It is soluble in water, benzene, chloroform, and methanol, but only slightly soluble in petroleum ether. Matrine has a melting point of 76°C (α-matrine), 87°C (β-matrine), 223°C (γ-matrine), and 84°C (δ-matrine), and a specific optical rotation of +31 to +36°.

History

As early as the 1930s, the Soviet Union began to study Sophora flavescens, and the china research began in 1972. Sophora flavescens in the chemical composition are divided into two major categories of alkaloids and flavonoids. Global research efforts are currently concentrated on studying alkaloids. So far, there are 23 species of alkaloids isolated and identified in roots, stems, leaves, and flowers of Sophora flavescens. The main components of Sophora flavescens have obvious anti-cancer effects, and oxymatrine has anti-cancer and antiaging effects.

Verwenden

(+)-Matrine is an alkaloid compound extracted from the roots of Sophora species which maintain anti-inflammatory, anti-cancer and a host of other positive pharmacological effects. Apoptotic agent.

Definition

ChEBI: Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and μ-receptor agonist.

Indications

In clinical settings, matrine injection was used for chronic active hepatitis, and suppository was used for trichomoniasis or Candida vaginitis and chronic cervicitis and can also be used for senile vaginitis and pelvic inflammatory disease.

Pharmakologie

Matrine has antiarrhythmic, anti-inflammatory, anti-fibrosis, and anti-tumor effects. It has significant effects of negative frequency and positive inotropic action, which can enhance myocardial contractility, slow down the heart rate, and extend the PR and QTC interval. Matrine can promote the expression of the bcl-2 gene and can improve the ratio of bcl-2/Bax to inhibit apoptosis of myocardial cell caused by myocardial ischemia reperfusion and then reduce myocardial deficiency caused by coronary atherosclerotic heart disease and myocardial infarction to achieve the role of antiarrhythmic. In addition, matrine can also play an anti-pulmonary fibrosis effect by inhibiting the proliferation of lung fibroblasts and the expression of pulmonary interstitial fibroblasts (FN).

Clinical Use

Matrine has multiple pharmacological effects and can treat a variety of diseases in clinical setting. At present, the researches on matrine are mainly focused on antiliver injury and liver fibrosis and anti-tumor and anti-cardiovascular diseases. It was worthy of attention that matrine has other pharmacological activities, such as leukocyte-elevating effects and anti-virus effects, and these effects were necessary for further development and utilization. The pharmacological effects of matrine stayed in the experimental phase, and they need further development and research to promote the development of clinical practice. Improvements in the modern formulation of matrine can improve their clinical application.

Matrine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Matrine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 628)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 3010 58
Wuhan Haorong Biotechnology Co.,ltd
+86-18565342920; +8618565342920
sales@chembj.net China 289 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 997 58
Chongqing Zhihe Biopharmaceutical Co., Ltd.
+86-18580541567; +8618580541567
sales@zhswyy.com China 301 58
airuikechemical co., ltd.
+undefined86-15315557071
sales02@sdzhonghuimaterial.com China 983 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.
+8615373025980
clara@hbshengyang.com China 875 58

519-02-8()Verwandte Suche:


  • alpha-matrine
  • SOPHOCARPIDINE
  • (+)-MATRINE
  • MATRINE
  • MATRINIUM
  • MATRENE
  • Alkaloids Sophora Flavescen
  • Matrines
  • MATRINE, 98.0% BY HPLC
  • MATRINE(P)
  • MASSMARK 1621
  • Matrine,Sophocarpidine
  • (7aα,13aR,13bα,13cα)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridine-10-one
  • (7aα,13aβ,13bα,13cα)-2,3,6,7,7a,12,13,13a,13b,13c-Decahydro-1H,5H,8H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridine-10(11H)-one
  • Matrine,Matridin-15-one, Sophocarpidine
  • Matridin-15-one (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
  • 7,13-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadecan-6-one
  • Matrine((+)-Matrine)
  • Matrine (alpha-matrine)
  • Vegard
  • Matrine, froM Sophora flavescens
  • 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aS,13aR,13bR,13cS)-
  • Matridin-15-one (9CI)
  • Matrine, >=98%
  • Lepidium meyenii Walp extract
  • Matridin-15-one Sophocarpidine
  • Matrine 519-02-8
  • Matrine, 98%, from Sophora flavescens
  • Matrine CRS
  • 519-02-8 Matrine Insecticide Biological Pesticides for Formosan subterranean termite
  • (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
  • Matrine Solution in Methanol, 1000μg/mL
  • (41S,7aS,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one
  • (41S,7aS,13aR,13bR)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
  • Rhubarb extract/emodin
  • Rhubarb Extract/ Rhubarb Extrat anthraquinone
  • Rhubarb Extract/ Chrysophanic acid
  • Matrine USP/EP/BP
  • (+)-Matrine (Vegard)
  • Matrine, puriss, 99%
  • Sophora flavescens Ait extract Matrine
  • Pesticide Matrine
  • matrine / Radix Flavescentis Extract
  • (41S,7aS,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one
  • Sophocarpidine / Matrine
  • Matrine in Methanol
  • Matrine 100 μg/ml Acetonitrile
  • Matrine in Acetonitrile
  • 519-02-8
  • 26904-63-3
  • 51-92-8
  • C15H24ON2
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • natural product
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