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(R)-(-)-1,2-Propanediol

(R)-(-)-1,2-Propanediol Struktur
4254-14-2
CAS-Nr.
4254-14-2
Englisch Name:
(R)-(-)-1,2-Propanediol
Synonyma:
(R)-propane-1,2-diol;(R)-1,2-PROPANEDIOL;R-1,2-PD;(R)-1,2-propandiol;(R)-(-)-PROPANEDIOL;(2R)-1,2-Propanediol;(2R)-PROPANE-1,2-DIOL;(R)-(-)-1,2-PROPANEDIOL;(R)-(-)-PROPYLENE GLYCOL;Intermediate For Tenofovir
CBNumber:
CB8249625
Summenformel:
C3H8O2
Molgewicht:
76.09
MOL-Datei:
4254-14-2.mol

(R)-(-)-1,2-Propanediol Eigenschaften

Schmelzpunkt:
-57C
alpha 
-17 º (c=neat)
Siedepunkt:
186-188 °C765 mm Hg(lit.)
Dichte
1.04 g/mL at 25 °C(lit.)
Brechungsindex
n20/D 1.434(lit.)
Flammpunkt:
225 °F
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
Miscible with acetone, chloroform, ethanol (95%), glycerin, and water; soluble at 1 in 6 parts of ether; not miscible with light mineral oil or fixed oils, but will dissolve some essential oils.
pka
14.49±0.20(Predicted)
Aggregatzustand
clear liquid
Farbe
Colorless to Light orange to Yellow
Wichte
1.036
Optische Aktivit?t
[α]20/D 16.5°, neat
Sensitive 
Hygroscopic
Merck 
14,7855
BRN 
1718872
CAS Datenbank
4254-14-2(CAS DataBase Reference)
NIST chemische Informationen
R-(-)-1,2-propanediol(4254-14-2)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher F,Xn
R-S?tze: 20-65-15-10
S-S?tze: 24/25-43-7/8
WGK Germany  1
3
HS Code  29053200
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

(R)-(-)-1,2-Propanediol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20:Gesundheitssch?dlich beim Einatmen.
R65:Gesundheitssch?dlich: kann beim Verschlucken Lungensch?den verursachen.
R15:Reagiert mit Wasser unter Bildung hochentzündlicher Gase.
R10:Entzündlich.

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S43:Zum L?schen . . . (vom Hersteller anzugeben) verwenden (wenn Wasser die Gefahr erh?ht, anfügen: "Kein Wasser verwenden").
S7/8:Beh?lter trocken und dicht geschlossen halten.

Chemische Eigenschaften

Colorless to light yellow liqui

Verwenden

R-(-)-1,2-Propanediol, is a chiral building blocks that can be used for variety of chemical synthesis.

Vorbereitung Methode

Propylene is converted to chlorohydrin by chlorine water and hydrolyzed to 1,2-propylene oxide. With further hydrolysis, 1,2- propylene oxide is converted to propylene glycol.

Pharmazeutische Anwendungen

Propylene glycol has become widely used as a solvent, extractant, and preservative in a variety of parenteral and nonparenteral pharmaceutical formulations. It is a better general solvent than glycerin and dissolves a wide variety of materials, such as corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A and D), most alkaloids, and many local anesthetics.
As an antiseptic it is similar to ethanol, and against molds it is similar to glycerin and only slightly less effective than ethanol. Propylene glycol is commonly used as a plasticizer in aqueous film-coating formulations.
Propylene glycol is also used in cosmetics and in the food industry as a carrier for emulsifiers and as a vehicle for flavors in preference to ethanol, since its lack of volatility provides a more uniform flavor.

Lager

At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed container, protected from light, in a cool, dry place.

Inkompatibilit?ten

Propylene glycol is incompatible with oxidizing reagents such as potassium permanganate.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; inhalations; ophthalmic, oral, otic, percutaneous, rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

(R)-(-)-1,2-Propanediol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(R)-(-)-1,2-Propanediol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 308)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 18751 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211
info@longyupharma.com China 2541 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58

4254-14-2()Verwandte Suche:


  • (2R)-PROPANE-1,2-DIOL
  • (R)-(-)-PROPYLENE GLYCEROL
  • (R)-(-)-PROPYLENE GLYCOL
  • (R)-(-)-PROPANEDIOL
  • (R)-(-)-1,2-Propyleneglycol
  • (R)-(-)-1,2-PROPANEDIOL
  • (R)-(-)-1,2-DIHYDROXYPROPANE
  • (R)-1,2-propandiol
  • (R-(--1,2-Propanediol))-IntermediateForTenofovir
  • Intermediate For Tenofovir
  • (R)-(-)-1,2-Propanediol,98%
  • (R)-(-)-1,2-Propanediol 4254-14-2
  • (R)-(-)-Propylene glycerol, (R)-(-)-Propylene glycol
  • (2R)-1,2-Propanediol
  • R-1,2-PD
  • R-(-)-1,2-PROPANEDIOL / R-(-)-PROPYLENEGLYCEROL
  • (R)-(-)-1,2-Propanediol,96%
  • (R)-(-)-1,2-Propanediol, 99%, ee: 98%
  • (R)-(-)-1,2-Propanediol, ee: 98%
  • (R)-(-)-1,2-Dihydroxypropane (R)-(-)-Propylene Glycol
  • (R)-(-)-1,2-Propanediol 96%
  • 1,2-Propanediol, (R)- (9CI)
  • (R)-(-)-1,2-Propanediol>
  • (R)-propane-1,2-diol
  • (R)-1,2-PROPANEDIOL
  • Tenofovir disoproxil Impurity 93
  • phenyl hydrogen ((6-amino-9H-purin-9-yl)methyl)phosphonate
  • 4254-14-2
  • CH2OHCHOHCH3
  • HOCH2CH2CH2OH
  • CH3CHOHCH2OH
  • Organic Building Blocks
  • Polyols
  • Asymmetric Synthesis
  • Simple Alcohols (Chiral)
  • Chiral Building Blocks
  • chiral
  • Chiral Building Blocks
  • Simple Alcohols (Chiral)
  • Synthetic Organic Chemistry
  • Chiral Compounds
  • Diols
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