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Prazosin

Prazosin Struktur
19216-56-9
CAS-Nr.
19216-56-9
Bezeichnung:
Prazosin
Englisch Name:
Prazosin
Synonyma:
pressin;PRAZOSIN;furazosin;minipress;AKOS B020009;PrazosinBase;Terazosin-010;Prazosin USP/EP/BP;ART-CHEM-BB B020009;Terazosin Impurity15
CBNumber:
CB8120869
Summenformel:
C19H21N5O4
Molgewicht:
383.4
MOL-Datei:
19216-56-9.mol

Prazosin Eigenschaften

Schmelzpunkt:
278-280°C
Siedepunkt:
510.33°C (rough estimate)
Dichte
1.3275 (rough estimate)
Brechungsindex
1.7600 (estimate)
storage temp. 
2-8°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly, Heated)
Aggregatzustand
Solid
pka
pKa 6.54(50% EtOH) (Uncertain)
Farbe
White to Off-White
Wasserl?slichkeit
3.2mg/L(22.5 ºC)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P321 Besondere Behandlung
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P362 Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

Prazosin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Prazosin is used for treating mid-to-moderate hypertension. When using this drug, blood pressure is reduced without any significant change in indicators of cardiac function such as frequency, coronary flow, or cardiac output.

Definition

ChEBI: A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Clinical Use

Prazosin is effective in reducing all grades of hypertension. The drug can be administered alone in mild and (in some instances) moderate hypertension.When the hypertension is moderate or severe, prazosin generally is given in combination with a thiazide diuretic and a -blocker. The antihypertensive actions of prazosin are considerably potentiated by coadministration of thiazides or other types of antihypertensive drugs.
Prazosin may be particularly useful when patients cannot tolerate other classes of antihypertensive drugs or when blood pressure is not well controlled by other drugs. Since prazosin does not significantly influence blood uric acid or glucose levels, it can be used in hypertensive patients whose condition is complicated by diabetes mellitus or gout. Prazosin and other -antagonists find use in the management of benign prostatic obstruction, especially in patients who are not candidates for surgery. Blockade of -adrenoceptors in the base of the bladder and in the prostate apparently reduces the symptoms of obstruction and the urinary urgency that occurs at night.

Nebenwirkungen

Although less of a problem than with phenoxybenzamine or phentolamine, symptoms of postural hypotension, such as dizziness and light-headedness, are the most commonly reported side effects associated with prazosin therapy. These effects occur most frequently during initial treatment and when the dosage is sharply increased. Postural hypotension seems to be more pronounced during Na deficiency, as may occur in patients on a low-salt diet or being treated with diuretics, - blockers, or both.

Prazosin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Prazosin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 130)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9312 58
Hong Kong Excellence Biotechnology Co., Ltd.

ada@sh-teruiop.com China 875 58
sgtlifesciences pvt ltd
+8617013299288
dj@sgtlifesciences.com China 12373 58
Alfa Chemistry

Info@alfa-chemistry.com United States 24072 58

19216-56-9(Prazosin)Verwandte Suche:


  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-piperazin
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine.
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-piperazin
  • (4-(4-AMino-6,7-diMethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)Methanone hydrochloride salt
  • 2-(4-(2-furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline
  • 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-quinazolin
  • furazosin
  • PRAZOSIN
  • pressin
  • PIPERAZINE, 1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)-
  • minipress
  • AKOS B020009
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl-4-(2-furanylcarbonyl)) piperrazine
  • ART-CHEM-BB B020009
  • PrazosinBase
  • Prazosin Hcl 19237-84-4 / Base
  • (2-Furanyl)[4-(4-amino-6,7-dimethoxyquinazoline-2-yl)piperazine-1-yl] ketone
  • 1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-(furan-2-ylcarbonyl)piperazine
  • 2-[4-(2-Furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
  • [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone
  • [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-furan-2-ylmethanone
  • [4-(4-azanyl-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-furan-2-yl-methanone
  • 1-(4-aMino-6,7-diMethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hidrochloride
  • Terazosin EP Impurity K
  • Terazosin-010
  • Terazosin Impurity15
  • [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-methanone
  • Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-
  • Prazosin USP/EP/BP
  • 2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
  • Linagliptin Impurity CD10125
  • 19216-56-9
  • C19H21N5O4
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